Gene/Proteome Database (LMPD)

LMPD ID
LMP012562
Gene ID
26202
Species
Rattus norvegicus (Rat)
Gene Name
['NADH dehydrogenase subunit 5']
Gene Symbol
ND5
Alternate Names
NADH dehydrogenase subunit 5;
EC Number
1.6.5.3

Proteins

NADH dehydrogenase subunit 5 [Rattus norvegicus]
Refseq ID YP_665639
Protein GI 110189725
UniProt ID Q8SEZ0
Length 609
MNMMTSSILMILILLTTPIIISMTNLPKLIDFPSYATSSIKFSFLLSLLPLLLFFHHNTEYMITNWHWLTINSIKLTMSFKIDYFSILFLSVALFVTWSIMQFSSWYMHSDPHINRFIKYLMMFLITMLILTSANNLFQLFIGWEGVGIMSFLLIGWWYGRADANTAALQAILYNRVGDIGFILAMTWFCLNMNSWELQQIFLTNTNNLVPLTGLLIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLMIRFHPLTSNNSTIMTAMLCLGAITTLFTAICALTQNDIKKIVAFSTSSQLGLMMVTLGINQPYLAFLHICTHAFFKAMLFMCSGSIIHSLNDEQDIRKMGNMMKAMPFTSSCLIIGSLALTGMPFLTGFYSKDLIIEAINTCNTNAWALMITLIATSMTAVYSMRIIYFVTMTKPRYSPLITINENNPNLINPIKRLALGSILAGFLISLNIPPTNIQILTMPWHLKMTALLITILGFAIALELNNLTLNLSMSKPTKLSSFSTSLGYYPPIMHRIIPQKTLNSSYKLSLNLLDLIWLEKTIPKSTSITQTQLSKMMSNQKGLIKLYFLSFLITISLIFILHTLNPEWFQ

Gene Information

Entrez Gene ID
26202
Gene Name
['NADH dehydrogenase subunit 5']
Gene Symbol
ND5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005747 IEA:Ensembl C mitochondrial respiratory chain complex I
GO:0008137 IEA:UniProtKB-EC F NADH dehydrogenase (ubiquinone) activity
GO:0042773 IEA:InterPro P ATP synthesis coupled electron transport

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
M00142 NADH:ubiquinone oxidoreductase, mitochondria
ko00190 Oxidative phosphorylation
rno00190 Oxidative phosphorylation
rno05012 Parkinson's disease

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953747 Respiratory electron transport
5953748 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR010934 NADH dehydrogenase subunit 5, C-terminal
IPR003945 NADH-plastoquinone oxidoreductase, chain 5
IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit
IPR001516 NADH:ubiquinone oxidoreductase, chain 5/L, N-terminal

UniProt Annotations

Entry Information

Gene Name
['NADH dehydrogenase subunit 5']
Protein Entry
Q8SEZ0_RAT
UniProt ID
Q8SEZ0
Species
Rat

Comments

Comment Type Description
Catalytic Activity NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061104}.
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Similarity Belongs to the complex I subunit 5 family
Subcellular Location Mitochondrion inner membrane ; Multi-pass membrane protein {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061113}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012562 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
110189725 RefSeq YP_665639 609 NADH dehydrogenase subunit 5 [Rattus norvegicus]

Identical Sequences to LMP012562 proteins

Reference Database Accession Length Protein Name
GI:110189725 GenBank AIU45689.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]
GI:110189725 GenBank AIU45702.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]
GI:110189725 GenBank AIU45715.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]
GI:110189725 GenBank AIY51552.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]

Related Sequences to LMP012562 proteins

Reference Database Accession Length Protein Name
GI:110189725 GenBank ACP50316.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]
GI:110189725 GenBank ACP50329.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]
GI:110189725 GenBank ACP50342.1 609 NADH dehydrogenase subunit 5 (mitochondrion) [Rattus norvegicus]