Gene/Proteome Database (LMPD)
LMPD ID
LMP012564
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA thioesterase 7
Gene Symbol
Synonyms
Bach;
Alternate Names
cytosolic acyl coenzyme A thioester hydrolase; ACT; ACH1; LACH1; CTE-II; MTE-II; CTE-IIa; CTE-IIb; brain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase;
Chromosome
5
Map Location
5q36
EC Number
3.1.2.2
Summary
cleaves acyl-CoA thioesters to free fatty acids and coenzyme A [RGD, Feb 2006]
Orthologs
Proteins
| cytosolic acyl coenzyme A thioester hydrolase isoform 1 | |
|---|---|
| Refseq ID | NP_001139533 |
| Protein GI | 225690628 |
| UniProt ID | Q64559 |
| mRNA ID | NM_001146061 |
| Length | 381 |
| MKLLARTLYLWEVGRQVASWSLTSGQECLVLRETWWASMRAVRTRAVHHKPGHCIAMGRIMRPDDANVAGNVHGGTILKMIEEAGVIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVLSENILTGTKKLTNKATLWYVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPILNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSLNQEGKPLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP | |
| cytosolic acyl coenzyme A thioester hydrolase isoform 2 | |
|---|---|
| Refseq ID | NP_037346 |
| Protein GI | 225690626 |
| UniProt ID | Q64559 |
| mRNA ID | NM_013214 |
| Length | 372 |
| MAPPRLIHSAPGLLDTCSQIPPPPSPPPPAVAAKMSGPTTDTPAAIQICRIMRPDDANVAGNVHGGTILKMIEEAGVIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVLSENILTGTKKLTNKATLWYVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPILNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSLNQEGKPLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0044297 | IEA:Ensembl | C | cell body |
| GO:0005829 | IDA:RGD | C | cytosol |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0043005 | IEA:Ensembl | C | neuron projection |
| GO:0005634 | IEA:Ensembl | C | nucleus |
| GO:0047617 | IDA:RGD | F | acyl-CoA hydrolase activity |
| GO:0052689 | IEA:UniProtKB-KW | F | carboxylic ester hydrolase activity |
| GO:0036042 | IEA:Ensembl | F | long-chain fatty acyl-CoA binding |
| GO:0016290 | IEA:UniProtKB-EC | F | palmitoyl-CoA hydrolase activity |
| GO:0015937 | IEA:Ensembl | P | coenzyme A biosynthetic process |
| GO:0009062 | IEA:Ensembl | P | fatty acid catabolic process |
| GO:0036116 | IEA:Ensembl | P | long-chain fatty-acyl-CoA catabolic process |
| GO:0051792 | IEA:Ensembl | P | medium-chain fatty acid biosynthetic process |
| GO:0036114 | IEA:Ensembl | P | medium-chain fatty-acyl-CoA catabolic process |
| GO:1900535 | IEA:Ensembl | P | palmitic acid biosynthetic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=LACH1, MTE-II; IsoId=Q64559-2; Sequence=Displayed; Name=1; Synonyms=BACH, CTE-IIa, CTE-II; IsoId=Q64559-1; Sequence=VSP_016956; |
| Biophysicochemical Properties | Kinetic parameters: KM=5.9 uM for palmitoyl-CoA; Vmax=553 umol/min/mg enzyme with palmitoyl-CoA as substrate; |
| Catalytic Activity | Palmitoyl-CoA + H(2)O = CoA + palmitate. |
| Caution | These proteins have been named according to their molecular weight (see PubMed:11755680): BACH (also called CTE-IIa and CTE-II), LACH1 (also called MTE-II) and ACT (also called CTE- IIb). It is unknown whether ACT corresponds to another isoform |
| Domain | Both hydrolase domains are required for efficient activity |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. |
| Ptm | The N-terminus is blocked. |
| Similarity | Contains 2 acyl coenzyme A hydrolase domains |
| Subcellular Location | Cytoplasm. |
| Subunit | Homohexamer |
| Tissue Specificity | Isoform 1 is expressed constitutively in brain and testis. Isoform 2 is induced in liver by treatment with the peroxisome proliferator. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012564 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 225690628 | RefSeq | NP_001139533 | 381 | cytosolic acyl coenzyme A thioester hydrolase isoform 1 |
| 225690626 | RefSeq | NP_037346 | 372 | cytosolic acyl coenzyme A thioester hydrolase isoform 2 |
Identical Sequences to LMP012564 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:225690626 | GenBank | EDL81226.1 | 372 | acyl-CoA thioesterase 7, isoform CRA_a [Rattus norvegicus] |
| GI:225690628 | GenBank | EDL81227.1 | 381 | acyl-CoA thioesterase 7, isoform CRA_b [Rattus norvegicus] |
| GI:225690628 | SwissProt | Q64559.4 | 381 | RecName: Full=Cytosolic acyl coenzyme A thioester hydrolase; AltName: Full=ACH1; AltName: Full=ACT; AltName: Full=Acyl-CoA thioesterase 7; AltName: Full=Brain acyl-CoA hydrolase; Short=BACH; AltName: Full=CTE-IIa; AltName: Full=CTE-IIb; Short=CTE-II; AltName: Full=LACH1; AltName: Full=Long chain acyl-CoA thioester hydrolase; AltName: Full=MTE-II [Rattus norvegicus] |
Related Sequences to LMP012564 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:225690628 | DBBJ | BAA19627.2 | 381 | acyl-CoA hydrolase [Rattus norvegicus] |
| GI:225690626 | GenBank | EDL14929.1 | 379 | acyl-CoA thioesterase 7, isoform CRA_a [Mus musculus] |
| GI:225690626 | GenBank | EDL81226.1 | 372 | acyl-CoA thioesterase 7, isoform CRA_a [Rattus norvegicus] |
| GI:225690628 | GenBank | EDL81227.1 | 381 | acyl-CoA thioesterase 7, isoform CRA_b [Rattus norvegicus] |
| GI:225690626 | RefSeq | NP_579926.2 | 379 | cytosolic acyl coenzyme A thioester hydrolase isoform 2 [Mus musculus] |
| GI:225690628 | SwissProt | Q64559.4 | 381 | RecName: Full=Cytosolic acyl coenzyme A thioester hydrolase; AltName: Full=ACH1; AltName: Full=ACT; AltName: Full=Acyl-CoA thioesterase 7; AltName: Full=Brain acyl-CoA hydrolase; Short=BACH; AltName: Full=CTE-IIa; AltName: Full=CTE-IIb; Short=CTE-II; AltName: Full=LACH1; AltName: Full=Long chain acyl-CoA thioester hydrolase; AltName: Full=MTE-II [Rattus norvegicus] |