Gene/Proteome Database (LMPD)

LMPD ID
LMP012570
Gene ID
29224
Species
Rattus norvegicus (Rat)
Gene Name
carbonyl reductase 1
Gene Symbol
Cbr1
Synonyms
Cbr;
Alternate Names
carbonyl reductase [NADPH] 1; Cbr 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; 20-beta-hydroxysteroid dehydrogenase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase;
Chromosome
11
Map Location
11q11
EC Number
1.1.1.184
Summary
NADPH-dependent oxidoreductase that may be involved in ovarian follicular development [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cbr1

Proteins

carbonyl reductase [NADPH] 1
Refseq ID NP_062043
Protein GI 9506467
UniProt ID P47727
mRNA ID NM_019170
Length 277
MSSDRPVALVTGANKGIGFAIVRDLCRKFLGDVVLTARDESRGHEAVKQLQTEGLSPRFHQLDIDNPQSIRALRDFLLQEYGGLNVLVNNAGIAFKVVDPTPFHIQAEVTMKTNFFGTQDVCKELLPIIKPQGRVVNVSSSVSLRALKSCSPELQQKFRSETITEEELVGLMNKFIEDAKKGVHAKEGWPNSAYGVTKIGVTVLSRIYARKLNEERREDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPGAEGPHGQFVQDKKVEPW

Gene Information

Entrez Gene ID
29224
Gene Name
carbonyl reductase 1
Gene Symbol
Cbr1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:RGD C cytosol
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005902 IDA:RGD C microvillus
GO:0005634 IDA:RGD C nucleus
GO:0005886 IDA:RGD C plasma membrane
GO:0047021 IEA:UniProtKB-EC F 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0004090 ISS:UniProtKB F carbonyl reductase (NADPH) activity
GO:0050221 IEA:UniProtKB-EC F prostaglandin-E2 9-reductase activity
GO:0017144 ISS:UniProtKB P drug metabolic process
GO:0001542 IEP:RGD P ovulation from ovarian follicle
GO:0018205 NAS:RGD P peptidyl-lysine modification
GO:0042376 IDA:RGD P phylloquinone catabolic process
GO:0034698 IEP:RGD P response to gonadotropin
GO:0032496 IEP:RGD P response to lipopolysaccharide
GO:0033574 IEP:RGD P response to testosterone
GO:0042373 ISS:UniProtKB P vitamin K metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
carbonyl reductase 1
Protein Entry
CBR1_RAT
UniProt ID
P47727
Species
Rat

Comments

Comment Type Description
Catalytic Activity (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost- 13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13- enoate + NADPH.
Catalytic Activity (5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11- alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
Catalytic Activity R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity)
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Cytoplasm.
Subunit Monomer

Identical and Related Proteins

Unique RefSeq proteins for LMP012570 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9506467 RefSeq NP_062043 277 carbonyl reductase [NADPH] 1

Identical Sequences to LMP012570 proteins

Reference Database Accession Length Protein Name
GI:9506467 EMBL CAA59088.1 277 carbonyl reductase (NADPH) [Rattus norvegicus]
GI:9506467 EMBL CAA65230.1 277 carbonyl reductase (NADPH) [Rattus norvegicus]
GI:9506467 GenBank AEK13634.1 277 Sequence 46 from patent US 7972785
GI:9506467 SwissProt P47727.2 277 RecName: Full=Carbonyl reductase [NADPH] 1; AltName: Full=15-hydroxyprostaglandin dehydrogenase [NADP(+)]; AltName: Full=20-beta-hydroxysteroid dehydrogenase; AltName: Full=NADPH-dependent carbonyl reductase 1; AltName: Full=Prostaglandin 9-ketoreductase; AltName: Full=Prostaglandin-E(2) 9-reductase [Rattus norvegicus]

Related Sequences to LMP012570 proteins

Reference Database Accession Length Protein Name
GI:9506467 EMBL CAA59088.1 277 carbonyl reductase (NADPH) [Rattus norvegicus]
GI:9506467 EMBL CAA65230.1 277 carbonyl reductase (NADPH) [Rattus norvegicus]
GI:9506467 GenBank AEK13634.1 277 Sequence 46 from patent US 7972785