Gene/Proteome Database (LMPD)
LMPD ID
LMP012573
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
monoglyceride lipase
Gene Symbol
Synonyms
MAGL;
Alternate Names
monoglyceride lipase; MGL; monoacylglycerol lipase;
Chromosome
4
Map Location
4q34
EC Number
3.1.1.23
Summary
serine hydrolase that converts monoglycerides to fatty acid and glycerol; may play a role in retrograde signaling at central synapses and other forms of short-range neuronal communication [RGD, Feb 2006]
Orthologs
Proteins
| monoglyceride lipase | |
|---|---|
| Refseq ID | NP_612511 |
| Protein GI | 19923092 |
| UniProt ID | Q8R431 |
| mRNA ID | NM_138502 |
| Length | 303 |
| MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005811 | TAS:Reactome | C | lipid particle |
| GO:0045202 | IDA:RGD | C | synapse |
| GO:0047372 | ISS:UniProtKB | F | acylglycerol lipase activity |
| GO:0016787 | IDA:RGD | F | hydrolase activity |
| GO:0008289 | IMP:RGD | F | lipid binding |
| GO:0046464 | ISS:UniProtKB | P | acylglycerol catabolic process |
| GO:0019369 | ISS:UniProtKB | P | arachidonic acid metabolic process |
| GO:0006633 | IEA:UniProtKB-KW | P | fatty acid biosynthetic process |
| GO:0060292 | IEA:Ensembl | P | long term synaptic depression |
| GO:2000124 | IEA:Ensembl | P | regulation of endocannabinoid signaling pathway |
| GO:0050727 | ISS:UniProtKB | P | regulation of inflammatory response |
| GO:0051930 | ISS:UniProtKB | P | regulation of sensory perception of pain |
| GO:0009966 | ISS:UniProtKB | P | regulation of signal transduction |
| GO:0019433 | IEA:UniProtKB-UniPathway | P | triglyceride catabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| M00098 | Acylglycerol degradation |
| ko00561 | Glycerolipid metabolism |
| rno00561 | Glycerolipid metabolism |
| rno01100 | Metabolic pathways |
| ko04723 | Retrograde endocannabinoid signaling |
| rno04723 | Retrograde endocannabinoid signaling |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954466 | Acyl chain remodeling of DAG and TAG |
| 5954256 | Arachidonate production from DAG |
| 5953655 | Effects of PIP2 hydrolysis |
| 5953653 | G alpha (q) signalling events |
| 5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
| 5953473 | Glycerophospholipid biosynthesis |
| 5953642 | GPCR downstream signaling |
| 5953645 | Hemostasis |
| 5953753 | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 5953754 | Lipid digestion, mobilization, and transport |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953474 | Phospholipid metabolism |
| 5953644 | Platelet activation, signaling and aggregation |
| 5953391 | Signaling by GPCR |
| 5953381 | Signal Transduction |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Hydrolyzes glycerol monoesters of long-chain fatty acids. |
| Function | Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity) |
| Miscellaneous | Requires non-ionic detergent for solubilization. |
| Miscellaneous | Short-term inhibition causes analgesia, while long- term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity |
| Pathway | Glycerolipid metabolism; triacylglycerol degradation. |
| Similarity | Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family |
| Subunit | Homodimer |
| Tissue Specificity | Ubiquitous. Highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and testis. Highly expressed throughout the brain |
Identical and Related Proteins
Unique RefSeq proteins for LMP012573 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 19923092 | RefSeq | NP_612511 | 303 | monoglyceride lipase |
Identical Sequences to LMP012573 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:19923092 | GenBank | AAL87453.1 | 303 | monoglyceride lipase [Rattus norvegicus] |
| GI:19923092 | GenBank | AAI07921.1 | 303 | Monoglyceride lipase [Rattus norvegicus] |
| GI:19923092 | GenBank | EDL91316.1 | 303 | monoglyceride lipase, isoform CRA_a [Rattus norvegicus] |
| GI:19923092 | SwissProt | Q8R431.1 | 303 | RecName: Full=Monoglyceride lipase; Short=MGL; AltName: Full=Monoacylglycerol lipase; Short=MAGL [Rattus norvegicus] |
Related Sequences to LMP012573 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:19923092 | GenBank | AAL87453.1 | 303 | monoglyceride lipase [Rattus norvegicus] |
| GI:19923092 | GenBank | EDL91316.1 | 303 | monoglyceride lipase, isoform CRA_a [Rattus norvegicus] |
| GI:19923092 | SwissProt | Q8R431.1 | 303 | RecName: Full=Monoglyceride lipase; Short=MGL; AltName: Full=Monoacylglycerol lipase; Short=MAGL [Rattus norvegicus] |