Gene/Proteome Database (LMPD)

LMPD ID
LMP012574
Gene ID
29260
Species
Rattus norvegicus (Rat)
Gene Name
toll-like receptor 4
Gene Symbol
Tlr4
Alternate Names
toll-like receptor 4; toll4;
Chromosome
5
Map Location
5q24
Summary
receptor that functions as the major upstream sensor for hemorrhagic shock and lipopolysaccharide [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Tlr4

Proteins

toll-like receptor 4 precursor
Refseq ID NP_062051
Protein GI 25742799
UniProt ID Q9QX05
mRNA ID NM_019178
Length 835
MMPLLHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFTNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNSTCYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2699 peptide sequence: MMPLLHLAGTLIMALFLSCLRPGSL mat_peptide: 26..835 product: Toll-like receptor 4 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QX05.1) calculated_mol_wt: 93391 peptide sequence: NPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFTNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNSTCYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT

Gene Information

Entrez Gene ID
29260
Gene Name
toll-like receptor 4
Gene Symbol
Tlr4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IDA:RGD C cell surface
GO:0005737 IDA:RGD C cytoplasm
GO:0005887 TAS:RGD C integral component of plasma membrane
GO:0046696 ISS:UniProtKB C lipopolysaccharide receptor complex
GO:0001530 IDA:RGD F lipopolysaccharide binding
GO:0001875 ISS:UniProtKB F lipopolysaccharide receptor activity
GO:0043548 IPI:RGD F phosphatidylinositol 3-kinase binding
GO:0004872 IDA:RGD F receptor activity
GO:0004888 IEA:InterPro F transmembrane signaling receptor activity
GO:0002755 IEA:InterPro P MyD88-dependent toll-like receptor signaling pathway
GO:0071222 IEP:RGD P cellular response to lipopolysaccharide
GO:0071260 IEP:RGD P cellular response to mechanical stimulus
GO:0071300 IEP:RGD P cellular response to retinoic acid
GO:0050829 IEA:InterPro P defense response to Gram-negative bacterium
GO:0032497 ISS:UniProtKB P detection of lipopolysaccharide
GO:0016064 IEP:RGD P immunoglobulin mediated immune response
GO:0006954 IEP:RGD P inflammatory response
GO:0045087 TAS:RGD P innate immune response
GO:0002758 IMP:RGD P innate immune response-activating signal transduction
GO:0006691 IDA:RGD P leukotriene metabolic process
GO:0001774 IDA:RGD P microglial cell activation
GO:0043388 IMP:RGD P positive regulation of DNA binding
GO:0051092 IMP:RGD P positive regulation of NF-kappaB transcription factor activity
GO:0043065 IMP:RGD P positive regulation of apoptotic process
GO:0050729 IMP:RGD P positive regulation of inflammatory response
GO:0050731 IDA:RGD P positive regulation of peptidyl-tyrosine phosphorylation
GO:0051091 IMP:RGD P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0050707 IEA:InterPro P regulation of cytokine secretion
GO:0051930 IMP:RGD P regulation of sensory perception of pain
GO:0014823 IEP:RGD P response to activity
GO:0045471 IMP:RGD P response to ethanol
GO:0070542 IDA:RGD P response to fatty acid
GO:0051384 IEP:RGD P response to glucocorticoid
GO:1990268 IEP:RGD P response to gold nanoparticle
GO:0001666 IEP:RGD P response to hypoxia
GO:0032868 IEP:RGD P response to insulin
GO:0032496 IDA:RGD P response to lipopolysaccharide
GO:0043278 IEP:RGD P response to morphine
GO:0006979 IMP:RGD P response to oxidative stress
GO:0032570 IEP:RGD P response to progesterone
GO:0032526 IEP:RGD P response to retinoic acid
GO:0009636 IEP:RGD P response to toxic substance
GO:0003009 IEP:RGD P skeletal muscle contraction
GO:0034142 IEA:InterPro P toll-like receptor 4 signaling pathway
GO:0002224 IDA:RGD P toll-like receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko05146 Amoebiasis
rno05146 Amoebiasis
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
rno04066 HIF-1 signaling pathway
rno05161 Hepatitis B
ko05321 Inflammatory bowel disease (IBD)
rno05321 Inflammatory bowel disease (IBD)
ko05164 Influenza A
rno05164 Influenza A
ko05134 Legionellosis
rno05134 Legionellosis
ko05140 Leishmaniasis
rno05140 Leishmaniasis
ko05144 Malaria
rno05144 Malaria
ko05162 Measles
rno05162 Measles
rno04064 NF-kappa B signaling pathway
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko05133 Pertussis
rno05133 Pertussis
ko04145 Phagosome
rno04145 Phagosome
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
ko05323 Rheumatoid arthritis
rno05323 Rheumatoid arthritis
ko05132 Salmonella infection
rno05132 Salmonella infection
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko05152 Tuberculosis
rno05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR017241 Toll-like receptor
IPR027168 Toll-like receptor 4
IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

UniProt Annotations

Entry Information

Gene Name
toll-like receptor 4
Protein Entry
TLR4_RAT
UniProt ID
Q9QX05
Species
Rat

Comments

Comment Type Description
Domain The TIR domain mediates interaction with NOX4
Function Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low- density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42- binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion
Similarity Belongs to the Toll-like receptor family
Similarity Contains 1 LRRCT domain
Similarity Contains 1 TIR domain. {ECO:0000255|PROSITE- ProRule:PRU00204}.
Similarity Contains 16 LRR (leucine-rich) repeats
Subcellular Location Cell membrane ; Single-pass type I membrane protein . Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis
Subunit Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Interacts with MLK4; this interaction leads to negative regulation of TLR4 signaling. Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation

Identical and Related Proteins

Unique RefSeq proteins for LMP012574 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25742799 RefSeq NP_062051 835 toll-like receptor 4 precursor

Identical Sequences to LMP012574 proteins

Reference Database Accession Length Protein Name
GI:25742799 GenBank AAC13313.1 835 toll protein [Rattus norvegicus]
GI:25742799 GenBank ABH65776.1 835 Sequence 6 from patent US 7029861
GI:25742799 SwissProt Q9QX05.1 835 RecName: Full=Toll-like receptor 4; Short=Toll4; AltName: CD_antigen=CD284; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012574 proteins

Reference Database Accession Length Protein Name
GI:25742799 GenBank AAC13313.1 835 toll protein [Rattus norvegicus]
GI:25742799 GenBank ABH65776.1 835 Sequence 6 from patent US 7029861
GI:25742799 SwissProt Q9QX05.1 835 RecName: Full=Toll-like receptor 4; Short=Toll4; AltName: CD_antigen=CD284; Flags: Precursor [Rattus norvegicus]