Gene/Proteome Database (LMPD)

LMPD ID
LMP012575
Gene ID
29309
Species
Rattus norvegicus (Rat)
Gene Name
coenzyme Q3 methyltransferase
Gene Symbol
Coq3
Alternate Names
hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; DHHB-MT; DHHB-MTase; DHHB methyltransferase; coenzyme Q (ubiquinone); 2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; coenzyme Q3 homolog, methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase;
Chromosome
5
Map Location
5q21
EC Number
2.1.1.114
Summary
putative 3,4-dihydroxy-5-polyprenylbenzoate-MTase that may participate in the biosynthesis of ubiquinone (coenzyme Q) [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Coq3

Proteins

hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
Refseq ID NP_062060
Protein GI 9506505
UniProt ID Q63159
mRNA ID NM_019187
Length 286
MWLRSYRITFSCLTRLKTYRSSWKKLYSTSQTVDSKEVKTFQALAHSWWDEQGKFAPLHSMNDLRVPFIRDNLLKTSTNHDPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVAENIKIAQHHKSFDPVLDKRIQYRVCSLEETLNENAECFDAVVASEVVEHVNNLEMFIQCCYQVLKPGGSLFITTVNKTQLSYVLGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVETVAGMVYNPFSGYWHWTENTSLNYAAHAVRARAQEHLEPAESA

Gene Information

Entrez Gene ID
29309
Gene Name
coenzyme Q3 methyltransferase
Gene Symbol
Coq3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0008425 IEA:InterPro F 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
GO:0008689 IEA:UniProtKB-EC F 3-demethylubiquinone-9 3-O-methyltransferase activity
GO:0004395 IMP:RGD F hexaprenyldihydroxybenzoate methyltransferase activity
GO:0006071 IEA:Ensembl P glycerol metabolic process
GO:0006744 IMP:RGD P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00130 Ubiquinone and other terpenoid-quinone biosynthesis
rno00130 Ubiquinone and other terpenoid-quinone biosynthesis
M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5871 ubiquinol-9 biosynthesis (eukaryotic)

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954558 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR010233 Ubiquinone biosynthesis O-methyltransferase

UniProt Annotations

Entry Information

Gene Name
coenzyme Q3 methyltransferase
Protein Entry
COQ3_RAT
UniProt ID
Q63159
Species
Rat

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + 3,4-dihydroxy-5-all- trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy- 4-hydroxy-5-all-trans-polyprenylbenzoate.
Catalytic Activity S-adenosyl-L-methionine + 3- demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
Catalytic Activity S-adenosyl-L-methionine + 3-(all-trans- polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2- methoxy-6-(all-trans-polyprenyl)phenol.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity Belongs to the methyltransferase superfamily. UbiG/COQ3 family
Subcellular Location Mitochondrion matrix .

Identical and Related Proteins

Unique RefSeq proteins for LMP012575 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9506505 RefSeq NP_062060 286 hexaprenyldihydroxybenzoate methyltransferase, mitochondrial

Identical Sequences to LMP012575 proteins

Reference Database Accession Length Protein Name
GI:9506505 GenBank AAC37643.1 286 dihydroxypolyprenylbenzoate methyltransferase [Rattus norvegicus]
GI:9506505 PRF - 286 dihydroxypolyprenylbenzoate methyltransferase [Rattus norvegicus]

Related Sequences to LMP012575 proteins

Reference Database Accession Length Protein Name
GI:9506505 GenBank AAC37643.1 286 dihydroxypolyprenylbenzoate methyltransferase [Rattus norvegicus]
GI:9506505 GenBank AAH81811.1 343 Coq3 protein, partial [Rattus norvegicus]
GI:9506505 PRF - 286 dihydroxypolyprenylbenzoate methyltransferase [Rattus norvegicus]