Gene/Proteome Database (LMPD)
LMPD ID
LMP012579
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
sigma non-opioid intracellular receptor 1
Gene Symbol
Synonyms
Oprs1;
Alternate Names
sigma non-opioid intracellular receptor 1; sigma1R; sigma1-receptor; opioid receptor, sigma 1; sigma 1-type opioid receptor;
Chromosome
5
Map Location
5q22
Summary
mediates nerve growth factor induced neurite sprouting; may play a role in neuronal response to antidepressants [RGD, Feb 2006]
Orthologs
Proteins
| sigma non-opioid intracellular receptor 1 | |
|---|---|
| Refseq ID | NP_112258 |
| Protein GI | 13591888 |
| UniProt ID | Q9R0C9 |
| mRNA ID | NM_030996 |
| Length | 223 |
| MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATDVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP | |
Gene Information
Entrez Gene ID
Gene Name
sigma non-opioid intracellular receptor 1
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030054 | IEA:UniProtKB-KW | C | cell junction |
| GO:0042995 | IEA:UniProtKB-KW | C | cell projection |
| GO:0005783 | TAS:RGD | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005811 | IEA:UniProtKB-KW | C | lipid particle |
| GO:0005635 | IEA:Ensembl | C | nuclear envelope |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0004985 | IDA:RGD | F | opioid receptor activity |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0007399 | IDA:RGD | P | nervous system development |
| GO:0038003 | IDA:GOC | P | opioid receptor signaling pathway |
| GO:0043523 | ISS:UniProtKB | P | regulation of neuron apoptotic process |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sigma non-opioid intracellular receptor 1
Protein Entry
SGMR1_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9R0C9-1; Sequence=Displayed; Name=2; IsoId=Q9R0C9-2; Sequence=VSP_021988, VSP_021989; |
| Function | Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. {ECO:0000269|PubMed:11861817, ECO:0000269|PubMed:11988171, ECO:0000269|PubMed:15170821, ECO:0000269|PubMed:15466698, ECO:0000269|PubMed:16522641, ECO:0000269|PubMed:9489711}. |
| Interaction | P06761:Hspa5; NbExp=3; IntAct=EBI-1557826, EBI-916036; P63141:Kcna2 (xeno); NbExp=3; IntAct=EBI-1557826, EBI-644033; |
| Miscellaneous | Depletion by RNAi alters oligodendrocyte differentiation and enhances opioid analgesia. |
| Similarity | Belongs to the ERG2 family |
| Subcellular Location | Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding. |
| Subunit | Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4 |
| Tissue Specificity | Expressed in ependymocytes and neurons throughout the CNS from the olfactory bulb to the spinal cord. Expressed by progenitor, mature and satellite oligodendrocytes and by Schwann cells (at protein level). Expressed in liver, intestine, kidney, brain, lung and heart. Expressed by retinal cells. {ECO:0000269|PubMed:10771347, ECO:0000269|PubMed:11687279, ECO:0000269|PubMed:12535781, ECO:0000269|PubMed:15064136, ECO:0000269|PubMed:9489711}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012579 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13591888 | RefSeq | NP_112258 | 223 | sigma non-opioid intracellular receptor 1 |
Identical Sequences to LMP012579 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13591888 | GenBank | AAD01198.1 | 223 | brain sigma receptor [Rattus norvegicus] |
Related Sequences to LMP012579 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13591888 | GenBank | AAD01198.1 | 223 | brain sigma receptor [Rattus norvegicus] |
| GI:13591888 | GenBank | EDL98689.1 | 223 | opioid receptor, sigma 1, isoform CRA_a [Rattus norvegicus] |
| GI:13591888 | SwissProt | Q9R0C9.1 | 223 | RecName: Full=Sigma non-opioid intracellular receptor 1; AltName: Full=Sigma 1-type opioid receptor; Short=Sigma1-receptor; Short=Sigma1R [Rattus norvegicus] |