Gene/Proteome Database (LMPD)

LMPD ID
LMP012580
Gene ID
29337
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, gamma 2
Gene Symbol
Plcg2
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; PLC-IV; PLC-gamma-2; phospholipase C-IV; phospholipase C-gamma-2; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2;
Chromosome
19
Map Location
19q12
EC Number
3.1.4.11
Summary
has phosphoinositide-specific phospholipase C activity [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Plcg2

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Refseq ID NP_058864
Protein GI 8393984
UniProt ID P24135
mRNA ID NM_017168
Length 1265
MTTMVNVDTLPEYEKSQIKRALELGTVMTVFSARKSTPERRTVQMIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRHKADCCFTIFYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEDPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDMLMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFLVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLRLYQEKCNRRLREKRVSNSRFYS

Gene Information

Entrez Gene ID
29337
Gene Name
phospholipase C, gamma 2
Gene Symbol
Plcg2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:RGD C membrane
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0004435 IDA:RGD F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0006661 ISS:UniProtKB P phosphatidylinositol biosynthetic process
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0007204 IMP:RGD P positive regulation of cytosolic calcium ion concentration
GO:0051209 ISS:UniProtKB P release of sequestered calcium ion into cytosol
GO:0033198 IDA:RGD P response to ATP
GO:0032026 IDA:RGD P response to magnesium ion

KEGG Pathway Links

KEGG Pathway ID Description
ko04662 B cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko05169 Epstein-Barr virus infection
rno05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko05214 Glioma
rno05214 Glioma
rno04066 HIF-1 signaling pathway
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
ko04670 Leukocyte transendothelial migration
rno04670 Leukocyte transendothelial migration
rno01100 Metabolic pathways
ko05206 MicroRNAs in cancer
rno05206 MicroRNAs in cancer
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
rno04064 NF-kappa B signaling pathway
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
rno04014 Ras signaling pathway
rno04919 Thyroid hormone signaling pathway
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
IPR000008 C2 domain
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain
IPR000980 SH2 domain
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, gamma 2
Protein Entry
PLCG2_RAT
UniProt ID
P24135
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Ptm Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand- induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity (By similarity)
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Similarity Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Similarity Contains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subunit Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated)

Identical and Related Proteins

Unique RefSeq proteins for LMP012580 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393984 RefSeq NP_058864 1265 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Identical Sequences to LMP012580 proteins

Reference Database Accession Length Protein Name
GI:8393984 EMBL CBU87756.1 1265 unnamed protein product [Rattus norvegicus]
GI:8393984 EMBL CBU96703.1 1265 unnamed protein product [Rattus norvegicus]
GI:8393984 GenBank AGX54691.1 1265 Sequence 9738 from patent US 8541208
GI:8393984 GenBank AGX64131.1 1265 Sequence 28372 from patent US 8541208

Related Sequences to LMP012580 proteins

Reference Database Accession Length Protein Name
GI:8393984 EMBL CBF62880.1 1265 unnamed protein product [Rattus norvegicus]
GI:8393984 GenBank AAA41896.1 1265 phospholipase C type IV (PLP IV) [Rattus norvegicus]
GI:8393984 SwissProt P24135.1 1265 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; AltName: Full=Phosphoinositide phospholipase C-gamma-2; AltName: Full=Phospholipase C-IV; Short=PLC-IV; AltName: Full=Phospholipase C-gamma-2; Short=PLC-gamma-2 [Rattus norvegicus]