Gene/Proteome Database (LMPD)

LMPD ID
LMP012582
Gene ID
29347
Species
Rattus norvegicus (Rat)
Gene Name
fatty acid amide hydrolase
Gene Symbol
Faah
Alternate Names
fatty-acid amide hydrolase 1; oleamide hydrolase 1; anandamide amidohydrolase 1;
Chromosome
5
Map Location
5q36
EC Number
3.5.1.99
Summary
catalyzes the degradation and signal termination of the endocannabinoid class of signalling lipids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Faah

Proteins

fatty-acid amide hydrolase 1
Refseq ID NP_077046
Protein GI 13162304
UniProt ID P97612
mRNA ID NM_024132
Length 579
MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS

Gene Information

Entrez Gene ID
29347
Gene Name
fatty acid amide hydrolase
Gene Symbol
Faah
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 TAS:RGD C integral component of membrane
GO:0031090 IDA:UniProtKB C organelle membrane
GO:0004040 IDA:RGD F amidase activity
GO:0016884 IEA:InterPro F carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0017064 IDA:UniProtKB F fatty acid amide hydrolase activity
GO:0016788 IDA:RGD F hydrolase activity, acting on ester bonds
GO:0008289 IDA:RGD F lipid binding
GO:0005543 IMP:RGD F phospholipid binding
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0009062 IDA:UniProtKB P fatty acid catabolic process
GO:0006631 IMP:RGD P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04723 Retrograde endocannabinoid signaling
rno04723 Retrograde endocannabinoid signaling

Domain Information

InterPro Annotations

Accession Description
IPR000120 Amidase
IPR023631 Amidase signature domain
IPR020556 Amidase, conserved site
IPR015830 Amidase, fungi type

UniProt Annotations

Entry Information

Gene Name
fatty acid amide hydrolase
Protein Entry
FAAH1_RAT
UniProt ID
P97612
Species
Rat

Comments

Comment Type Description
Catalytic Activity Anandamide + H(2)O = arachidonic acid + ethanolamine.
Catalytic Activity Oleamide + H(2)O = oleic acid + NH(3).
Developmental Stage In the CNS it accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postnatal day 30, then decreases into adulthood.
Function Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity)
Similarity Belongs to the amidase family
Subcellular Location Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus membrane ; Single-pass membrane protein . Note=Seems to be associated with the endoplasmic reticulum and/or Golgi apparatus.
Subunit Homodimer. {ECO:0000269|PubMed:12459591, ECO:0000269|PubMed:18753625}.
Tissue Specificity Found in neuronal cells throughout the CNS. Expressed in liver and brain, and to a lesser extent in spleen, lung, kidney and testes

Identical and Related Proteins

Unique RefSeq proteins for LMP012582 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13162304 RefSeq NP_077046 579 fatty-acid amide hydrolase 1

Identical Sequences to LMP012582 proteins

Reference Database Accession Length Protein Name
GI:13162304 GenBank AED82878.1 579 Sequence 6 from patent US 7919495
GI:13162304 GenBank AEK13619.1 579 Sequence 31 from patent US 7972785
GI:13162304 RefSeq XP_003750049.1 579 PREDICTED: fatty-acid amide hydrolase 1 [Rattus norvegicus]
GI:13162304 RefSeq XP_008774266.1 579 PREDICTED: fatty-acid amide hydrolase 1 [Rattus norvegicus]

Related Sequences to LMP012582 proteins

Reference Database Accession Length Protein Name
GI:13162304 GenBank AED78185.1 579 Sequence 6 from patent US 7915261
GI:13162304 GenBank AED82874.1 579 Sequence 6 from patent US 7919494
GI:13162304 SwissProt P97612.1 579 RecName: Full=Fatty-acid amide hydrolase 1; AltName: Full=Anandamide amidohydrolase 1; AltName: Full=Oleamide hydrolase 1 [Rattus norvegicus]