Gene/Proteome Database (LMPD)

LMPD ID
LMP012588
Gene ID
29409
Species
Rattus norvegicus (Rat)
Gene Name
myelin-associated glycoprotein
Gene Symbol
Mag
Alternate Names
myelin-associated glycoprotein; siglec-4a; S-MAG (C-term.); brain neuron cytoplasmic protein 3; sialic acid-binding Ig-like lectin 4a;
Chromosome
1
Map Location
1q21
Summary
a cell adhesion molecule involved in axonal-glial and glial-glial interactions [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Mag

Proteins

myelin-associated glycoprotein precursor
Refseq ID NP_058886
Protein GI 8393742
UniProt ID P07722
mRNA ID NM_017190
Length 626
MIFLTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
sig_peptide: 1..16 note: myelin-associated glycoprotein signal peptide (put.); putative calculated_mol_wt: 1897 peptide sequence: MIFLTTLPLFWIMISA mat_peptide: 17..626 product: myelin-associated glycoprotein calculated_mol_wt: 67474 peptide sequence: SRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK

Gene Information

Entrez Gene ID
29409
Gene Name
myelin-associated glycoprotein
Gene Symbol
Mag
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0033270 IEA:Ensembl C paranode region of axon
GO:0030246 IEA:UniProtKB-KW F carbohydrate binding
GO:0007155 IEA:UniProtKB-KW P cell adhesion
GO:0021762 IEA:Ensembl P substantia nigra development

KEGG Pathway Links

KEGG Pathway ID Description
ko04514 Cell adhesion molecules (CAMs)
rno04514 Cell adhesion molecules (CAMs)

REACTOME Pathway Links

REACTOME Pathway ID Description
5953943 Axonal growth inhibition (RHOA activation)
5954052 Basigin interactions
5953650 Cell surface interactions at the vascular wall
5953645 Hemostasis
5953381 Signal Transduction
5953395 Signalling by NGF
5953945 p75 NTR receptor-mediated signalling
5953944 p75NTR regulates axonogenesis

Domain Information

InterPro Annotations

Accession Description
IPR013162 CD80_C2-set
IPR013098 Immunoglobulin I-set
IPR003599 Immunoglobulin subtype
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold

UniProt Annotations

Entry Information

Gene Name
myelin-associated glycoprotein
Protein Entry
MAG_RAT
UniProt ID
P07722
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=L-MAG; IsoId=P07722-1; Sequence=Displayed; Name=S-MAG; IsoId=P07722-2; Sequence=VSP_002529, VSP_002530;
Function Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity)
Similarity Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
Similarity Contains 1 Ig-like V-type (immunoglobulin-like) domain
Similarity Contains 4 Ig-like C2-type (immunoglobulin-like) domains
Subcellular Location Membrane; Single-pass type I membrane protein.
Subunit Binds to RTN4R

Identical and Related Proteins

Unique RefSeq proteins for LMP012588 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393742 RefSeq NP_058886 626 myelin-associated glycoprotein precursor

Identical Sequences to LMP012588 proteins

Reference Database Accession Length Protein Name
GI:8393742 RefSeq XP_006228886.1 626 PREDICTED: myelin-associated glycoprotein isoform X1 [Rattus norvegicus]
GI:8393742 RefSeq XP_006228887.1 626 PREDICTED: myelin-associated glycoprotein isoform X1 [Rattus norvegicus]
GI:8393742 RefSeq XP_008757359.1 626 PREDICTED: myelin-associated glycoprotein isoform X1 [Rattus norvegicus]
GI:8393742 RefSeq XP_008757360.1 626 PREDICTED: myelin-associated glycoprotein isoform X1 [Rattus norvegicus]

Related Sequences to LMP012588 proteins

Reference Database Accession Length Protein Name
GI:8393742 GenBank AAA41556.1 626 myelin-associated glycoprotein [Rattus norvegicus]
GI:8393742 GenBank AAA41557.1 626 myelin-associated glycoprotein precursor [Rattus norvegicus]
GI:8393742 SwissProt P07722.1 626 RecName: Full=Myelin-associated glycoprotein; AltName: Full=Brain neuron cytoplasmic protein 3; AltName: Full=Sialic acid-binding Ig-like lectin 4a; Short=Siglec-4a; Flags: Precursor [Rattus norvegicus]