Gene/Proteome Database (LMPD)

LMPD ID
LMP012590
Gene ID
29415
Species
Rattus norvegicus (Rat)
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
S1pr2
Synonyms
Edg5; H218; GPCR18; Gpcr13; snGPCR18;
Alternate Names
sphingosine 1-phosphate receptor 2; S1P2; AGR16; S1P receptor 2; S1P receptor Edg-5; G-protein coupled receptor 13; G-protein coupled receptor H218; sphingosine 1-phosphate receptor Edg-5; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5;
Chromosome
8
Map Location
8q13
Summary
G protein-coupled receptor for sphingosine 1-phosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for S1pr2

Proteins

sphingosine 1-phosphate receptor 2
Refseq ID NP_058888
Protein GI 8393469
UniProt ID P47752
mRNA ID NM_017192
Length 352
MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV

Gene Information

Entrez Gene ID
29415
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
S1pr2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 IDA:RGD F G-protein coupled receptor activity
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0090394 IEA:Ensembl P negative regulation of excitatory postsynaptic membrane potential

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954152 G alpha (i) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954244 Lysosphingolipid and LPA receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR004063 EDG-5 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 2
Protein Entry
S1PR2_RAT
UniProt ID
P47752
Species
Rat

Comments

Comment Type Description
Function Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012590 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393469 RefSeq NP_058888 352 sphingosine 1-phosphate receptor 2

Identical Sequences to LMP012590 proteins

Reference Database Accession Length Protein Name
GI:8393469 GenBank AAN99763.1 352 Sequence 24 from patent US 6485922
GI:8393469 GenBank AAP00841.1 352 Sequence 2 from patent US 6518414
GI:8393469 GenBank ABH85910.1 352 Sequence 21 from patent US 7052850
GI:8393469 GenBank EDL78338.1 352 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Rattus norvegicus]

Related Sequences to LMP012590 proteins

Reference Database Accession Length Protein Name
GI:8393469 GenBank AAA19241.1 352 pH218 [Rattus norvegicus]
GI:8393469 GenBank AAB44805.1 352 Sequence 2 from patent US 5585476
GI:8393469 SwissProt P47752.1 352 RecName: Full=Sphingosine 1-phosphate receptor 2; Short=S1P receptor 2; Short=S1P2; AltName: Full=AGR16; AltName: Full=Endothelial differentiation G-protein coupled receptor 5; AltName: Full=G-protein coupled receptor H218; AltName: Full=Sphingosine 1-phosphate receptor Edg-5; Short=S1P receptor Edg-5 [Rattus norvegicus]