Gene/Proteome Database (LMPD)

LMPD ID
LMP012593
Gene ID
29468
Species
Rattus norvegicus (Rat)
Gene Name
protein disulfide isomerase family A, member 3
Gene Symbol
Pdia3
Synonyms
ER60; ERp57; Grp58;
Alternate Names
protein disulfide-isomerase A3; Q-2; p58; ERp60; HIP-70; ER protein 57; ER protein 60; ER-60 protease; oxidoreductase ERp57; 58 kDa microsomal protein; disulfide isomerase ER-60; 58 kDa glucose-regulated protein; glucose regulated protein, 58 kDa; protein disulfide isomerase associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60;
Chromosome
3
Map Location
3q35
EC Number
5.3.4.1
Summary
interacts with thiazide-sensitive sodium-chloride cotransporter in the kidney and is induced by glucose deprivation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pdia3

Proteins

protein disulfide-isomerase A3 precursor
Refseq ID NP_059015
Protein GI 8393322
UniProt ID P11598
mRNA ID NM_017319
Length 505
MRFSCLALLPGVALLLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDLISYLQREATNPPIIQEEKPKKKKKAQEDL
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2402 peptide sequence: MRFSCLALLPGVALLLASALLASA mat_peptide: 25..505 product: protein disulfide-isomerase A3 calculated_mol_wt: 54206 peptide sequence: SDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDLISYLQREATNPPIIQEEKPKKKKKAQEDL

Gene Information

Entrez Gene ID
29468
Gene Name
protein disulfide isomerase family A, member 3
Gene Symbol
Pdia3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IBA:RefGenome C cell surface
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0005790 IDA:UniProtKB C smooth endoplasmic reticulum
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0003756 IBA:RefGenome F protein disulfide isomerase activity
GO:0045454 IEA:InterPro P cell redox homeostasis
GO:2001238 IEA:Ensembl P positive regulation of extrinsic apoptotic signaling pathway
GO:0006457 IBA:RefGenome P protein folding
GO:0034976 IBA:RefGenome P response to endoplasmic reticulum stress

KEGG Pathway Links

KEGG Pathway ID Description
ko04612 Antigen processing and presentation
rno04612 Antigen processing and presentation
ko04141 Protein processing in endoplasmic reticulum
rno04141 Protein processing in endoplasmic reticulum

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5954403 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
5954421 Antigen processing-Cross presentation
5953739 Asparagine N-linked glycosylation
5954327 Calnexin/calreticulin cycle
5954404 Class I MHC mediated antigen processing & presentation
5954420 ER-Phagosome pathway
5953410 Immune System
5953345 Metabolism of proteins
5954326 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
5953728 Post-translational protein modification

Domain Information

InterPro Annotations

Accession Description
IPR005788 Disulphide_isomerase
IPR005792 Protein disulphide isomerase
IPR017937 Thioredoxin, conserved site
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin_domain

UniProt Annotations

Entry Information

Gene Name
protein disulfide isomerase family A, member 3
Protein Entry
PDIA3_RAT
UniProt ID
P11598
Species
Rat

Comments

Comment Type Description
Catalytic Activity Catalyzes the rearrangement of -S-S- bonds in proteins.
Caution Was originally thought to be a phosphatidyl-inositol 4,5- bisphosphate phosphodiesterase type I (phospholipase C-alpha) then was thought (PubMed:1321829 and PubMed:1330685) to be a thiol protease
Enzyme Regulation Seems to be inhibited by acidic phospholipids.
Similarity Belongs to the protein disulfide isomerase family
Similarity Contains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular Location Endoplasmic reticulum . Endoplasmic reticulum lumen. Melanosome .
Subunit Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX (By similarity). Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with SERPINA2 and with the S and Z variants of SERPINA1 (By similarity)
Tissue Specificity In caput epididymal spermatozoa, detected in the head, mid and principal pieces. In cauda epididymal spermatozoa detected only in the acrosome (at protein level)

Identical and Related Proteins

Unique RefSeq proteins for LMP012593 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393322 RefSeq NP_059015 505 protein disulfide-isomerase A3 precursor

Identical Sequences to LMP012593 proteins

Reference Database Accession Length Protein Name
GI:8393322 DBBJ BAA09695.1 505 ER-60 protease [Rattus norvegicus]

Related Sequences to LMP012593 proteins

Reference Database Accession Length Protein Name
GI:8393322 DBBJ BAA09695.1 505 ER-60 protease [Rattus norvegicus]
GI:8393322 GenBank AAH62393.1 505 Protein disulfide isomerase family A, member 3 [Rattus norvegicus]
GI:8393322 SwissProt P11598.2 505 RecName: Full=Protein disulfide-isomerase A3; AltName: Full=58 kDa glucose-regulated protein; AltName: Full=58 kDa microsomal protein; Short=p58; AltName: Full=Disulfide isomerase ER-60; AltName: Full=Endoplasmic reticulum resident protein 57; Short=ER protein 57; Short=ERp57; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ER protein 60; Short=ERp60; AltName: Full=HIP-70; AltName: Full=Q-2; Flags: Precursor [Rattus norvegicus]