Gene/Proteome Database (LMPD)

LMPD ID
LMP012594
Gene ID
29469
Species
Rattus norvegicus (Rat)
Gene Name
lipopolysaccharide binding protein
Gene Symbol
Lbp
Synonyms
Bpifd2;
Alternate Names
lipopolysaccharide-binding protein; BPI fold containing family D, member 2;
Chromosome
3
Map Location
3q42
Summary
binds lipopolysaccharide on outer membrane of gram negative bacteria; involved in immune response [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lbp

Proteins

lipopolysaccharide-binding protein precursor
Refseq ID NP_058904
Protein GI 139948891
UniProt ID Q3MID7
mRNA ID NM_017208
Length 481
MKSATGPLLPTLLGLLLLSIPRTQGVNPAMVVRITDKGLEYAAKEGLLSLQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQSCQLRGSSLKPLPGRGLSLSISDSSISVRGKWKVRRSFVKLHGSFDLDVKGVTISVDLLLGVDPSGRPTVTASGCSNRIRDLELHVSGNVGWLLNLFHNQIESKLQKVLESKICEMIQKSVTSDLQPYLQTLPVTADIDTILGIDYSLVAAPQAKAQTLDVMFKGEIFNRNHRSPVTTPTPTMSLPEDSKQMVYFAISDQAFNIATRVYHQAGYLNFTITDDMLPPDSNIRLNTKAFRPFTPLITRKYPDMNLELLGTVVSAPLLNVSPGNLSLAPQMEIEGFVILPSSARESVFRLGVVTNVFVSLTFDNSKVTGMLHPEKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNDELAKGFPLPLPRRIKLHDLDFQIHKNFLYLGANVQYMRV
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2591 peptide sequence: MKSATGPLLPTLLGLLLLSIPRTQG mat_peptide: 26..481 product: Lipopolysaccharide-binding protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q63313.1) calculated_mol_wt: 50925 peptide sequence: VNPAMVVRITDKGLEYAAKEGLLSLQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQSCQLRGSSLKPLPGRGLSLSISDSSISVRGKWKVRRSFVKLHGSFDLDVKGVTISVDLLLGVDPSGRPTVTASGCSNRIRDLELHVSGNVGWLLNLFHNQIESKLQKVLESKICEMIQKSVTSDLQPYLQTLPVTADIDTILGIDYSLVAAPQAKAQTLDVMFKGEIFNRNHRSPVTTPTPTMSLPEDSKQMVYFAISDQAFNIATRVYHQAGYLNFTITDDMLPPDSNIRLNTKAFRPFTPLITRKYPDMNLELLGTVVSAPLLNVSPGNLSLAPQMEIEGFVILPSSARESVFRLGVVTNVFVSLTFDNSKVTGMLHPEKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNDELAKGFPLPLPRRIKLHDLDFQIHKNFLYLGANVQYMRV

Gene Information

Entrez Gene ID
29469
Gene Name
lipopolysaccharide binding protein
Gene Symbol
Lbp
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 IEA:Ensembl C cell surface
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0001530 IEA:Ensembl F lipopolysaccharide binding
GO:0070891 IEA:Ensembl F lipoteichoic acid binding
GO:0006953 IEA:Ensembl P acute-phase response
GO:0071223 IEA:Ensembl P cellular response to lipoteichoic acid
GO:0050829 IEA:Ensembl P defense response to Gram-negative bacterium
GO:0050830 IEA:Ensembl P defense response to Gram-positive bacterium
GO:0032490 IEA:Ensembl P detection of molecule of bacterial origin
GO:0045087 IEA:Ensembl P innate immune response
GO:0002232 IEA:Ensembl P leukocyte chemotaxis involved in inflammatory response
GO:0015920 IEA:Ensembl P lipopolysaccharide transport
GO:0031663 IEA:Ensembl P lipopolysaccharide-mediated signaling pathway
GO:0002281 IEA:Ensembl P macrophage activation involved in immune response
GO:0044130 IEA:Ensembl P negative regulation of growth of symbiont in host
GO:0032720 IEA:Ensembl P negative regulation of tumor necrosis factor production
GO:0032722 IEA:Ensembl P positive regulation of chemokine production
GO:0032755 IEA:Ensembl P positive regulation of interleukin-6 production
GO:0032757 IEA:Ensembl P positive regulation of interleukin-8 production
GO:0043032 IEA:Ensembl P positive regulation of macrophage activation
GO:0090023 IEA:Ensembl P positive regulation of neutrophil chemotaxis
GO:0060265 IEA:Ensembl P positive regulation of respiratory burst involved in inflammatory response
GO:0034145 IEA:Ensembl P positive regulation of toll-like receptor 4 signaling pathway
GO:0042535 IEA:Ensembl P positive regulation of tumor necrosis factor biosynthetic process
GO:0032760 IEA:Ensembl P positive regulation of tumor necrosis factor production

KEGG Pathway Links

KEGG Pathway ID Description
rno04064 NF-kappa B signaling pathway
ko05132 Salmonella infection
rno05132 Salmonella infection
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05152 Tuberculosis
rno05152 Tuberculosis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953410 Immune System
5953409 Innate Immune System
5953552 Toll Like Receptor 4 (TLR4) Cascade
5953553 Toll-Like Receptors Cascades
5953771 Transfer of LPS from LBP carrier to CD14

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017954 Lipid-binding serum glycoprotein, conserved site

UniProt Annotations

Entry Information

Gene Name
lipopolysaccharide binding protein
Protein Entry
Q3MID7_RAT
UniProt ID
Q3MID7
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012594 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
139948891 RefSeq NP_058904 481 lipopolysaccharide-binding protein precursor

Identical Sequences to LMP012594 proteins

Reference Database Accession Length Protein Name
GI:139948891 GenBank AAI01907.1 481 Lipopolysaccharide binding protein [Rattus norvegicus]
GI:139948891 GenBank EDL96653.1 481 rCG32348 [Rattus norvegicus]

Related Sequences to LMP012594 proteins

Reference Database Accession Length Protein Name
GI:139948891 GenBank AAA21835.1 481 lipopolysaccharide binding protein [Rattus norvegicus]
GI:139948891 GenBank AAI01907.1 481 Lipopolysaccharide binding protein [Rattus norvegicus]
GI:139948891 GenBank EDL96653.1 481 rCG32348 [Rattus norvegicus]