Gene/Proteome Database (LMPD)

LMPD ID
LMP012596
Gene ID
29473
Species
Rattus norvegicus (Rat)
Gene Name
amine oxidase, copper containing 3
Gene Symbol
Aoc3
Synonyms
SSAO;
Alternate Names
membrane primary amine oxidase; VP97; VAP-1; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase;
Chromosome
10
Map Location
10q32.1
EC Number
1.4.3.21
Summary
localized to the adipocyte plasma membrane and to glucose transporter Glut4 containing vesicles [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Aoc3

Proteins

membrane primary amine oxidase
Refseq ID NP_113770
Protein GI 71896590
UniProt ID O08590
mRNA ID NM_031582
Length 763
MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK

Gene Information

Entrez Gene ID
29473
Gene Name
amine oxidase, copper containing 3
Gene Symbol
Aoc3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009986 ISS:UniProtKB C cell surface
GO:0005615 IDA:RGD C extracellular space
GO:0016021 ISS:UniProtKB C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0052595 IEA:UniProtKB-EC F aliphatic-amine oxidase activity
GO:0052594 IEA:UniProtKB-EC F aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0005507 IEA:InterPro F copper ion binding
GO:0052596 IEA:UniProtKB-EC F phenethylamine:oxygen oxidoreductase (deaminating) activity
GO:0008131 ISS:UniProtKB F primary amine oxidase activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0048038 ISS:UniProtKB F quinone binding
GO:0052593 IEA:UniProtKB-EC F tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0007568 IEP:RGD P aging
GO:0009308 ISS:UniProtKB P amine metabolic process
GO:0007155 ISS:UniProtKB P cell adhesion
GO:0042755 IMP:RGD P eating behavior
GO:0002523 IMP:RGD P leukocyte migration involved in inflammatory response
GO:0002675 IMP:RGD P positive regulation of acute inflammatory response
GO:0010828 IDA:RGD P positive regulation of glucose transport
GO:0002687 IMP:RGD P positive regulation of leukocyte migration
GO:0008217 IMP:RGD P regulation of blood pressure
GO:0035902 IMP:RGD P response to immobilization stress

KEGG Pathway Links

KEGG Pathway ID Description
ko00260 Glycine, serine and threonine metabolism
rno00260 Glycine, serine and threonine metabolism
rno01100 Metabolic pathways
ko00360 Phenylalanine metabolism
rno00360 Phenylalanine metabolism
ko00350 Tyrosine metabolism
rno00350 Tyrosine metabolism
ko00410 beta-Alanine metabolism
rno00410 beta-Alanine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015801 Cu_amine_oxidase_N2/3
IPR015802 Cu_amine_oxidase_N3

UniProt Annotations

Entry Information

Gene Name
amine oxidase, copper containing 3
Protein Entry
AOC3_RAT
UniProt ID
O08590
Species
Rat

Comments

Comment Type Description
Catalytic Activity RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 2 calcium ions per subunit. ;
Cofactor Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence= ; Note=Binds 1 copper ion per subunit. ;
Cofactor Name=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence= ; Note=Contains 1 topaquinone per subunit. ;
Function Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity)
Ptm N- and O-glycosylated
Ptm Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
Similarity Belongs to the copper/topaquinone oxidase family
Subcellular Location Membrane {ECO:0000269|PubMed:8520629, ECO:0000269|PubMed:9083076}; Single-pass type II membrane protein .
Subunit Homodimer; disulfide-linked. Forms a heterodimer with AOC2 (By similarity)
Tissue Specificity Highly expressed in adipocytes, aorta and lung. Expressed at lower levels in heart, kidney, large intestine, liver, small intestine and stomach

Identical and Related Proteins

Unique RefSeq proteins for LMP012596 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71896590 RefSeq NP_113770 763 membrane primary amine oxidase

Identical Sequences to LMP012596 proteins

Reference Database Accession Length Protein Name
GI:71896590 GenBank AAI00614.1 763 Amine oxidase, copper containing 3 (vascular adhesion protein 1) [Rattus norvegicus]
GI:71896590 SwissProt O08590.4 763 RecName: Full=Membrane primary amine oxidase; AltName: Full=Copper amine oxidase; AltName: Full=Semicarbazide-sensitive amine oxidase; Short=SSAO; AltName: Full=VP97; AltName: Full=Vascular adhesion protein 1; Short=VAP-1 [Rattus norvegicus]

Related Sequences to LMP012596 proteins

Reference Database Accession Length Protein Name
GI:71896590 DBBJ BAD74047.1 763 semicarbazide-sensitive amine oxidase [Rattus norvegicus]
GI:71896590 GenBank AAI00614.1 763 Amine oxidase, copper containing 3 (vascular adhesion protein 1) [Rattus norvegicus]
GI:71896590 SwissProt O08590.4 763 RecName: Full=Membrane primary amine oxidase; AltName: Full=Copper amine oxidase; AltName: Full=Semicarbazide-sensitive amine oxidase; Short=SSAO; AltName: Full=VP97; AltName: Full=Vascular adhesion protein 1; Short=VAP-1 [Rattus norvegicus]