Gene/Proteome Database (LMPD)

LMPD ID
LMP012606
Gene ID
29540
Species
Rattus norvegicus (Rat)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol
Hsd17b7
Alternate Names
3-keto-steroid reductase; PRAP; 17-beta-HSD 7; PRL receptor-associated protein; estradiol 17-beta-dehydrogenase 7; 17-beta-hydroxysteroid dehydrogenase 7; hydroxysteroid dehydrogenase 17 beta, type 7;
Chromosome
13
Map Location
13q24
EC Number
1.1.1.270
Summary
a phosphoprotein that associates with the short form of the prolactin receptor [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hsd17b7

Proteins

3-keto-steroid reductase
Refseq ID NP_058931
Protein GI 8393576
UniProt ID Q62904
mRNA ID NM_017235
Length 334
MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKAGAVRDALLASHPSAEVSIVQMDVSNLQSVVRGAEEVKRRFQRLDYLYLNAGIMPNPQLNLKAFFCGIFSRNVIHMFSTAEGLLTQNDKITADGFQEVFETNLFGHFILIRELEPLLCHSDNPSQLIWTSSRNAKKSNFSLEDIQHAKGQEPYSSSKYATDLLNVALNRNFNQKGLYSSVTCPGVVMTNLTYGILPPFVWTLLLPVIWLLRFFAHAFTVTPYNGAEALVWLFHQKPESLNPLTKYLSGTTGLGTNYVKGQKMDVDEDTAEKFYKTLLELEKQVRITIQKSDHHS

Gene Information

Entrez Gene ID
29540
Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol
Hsd17b7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0000253 IEA:UniProtKB-EC F 3-keto sterol reductase activity
GO:0004303 IEA:UniProtKB-EC F estradiol 17-beta-dehydrogenase activity
GO:0005148 IMP:RGD F prolactin receptor binding
GO:0006695 IEA:Ensembl P cholesterol biosynthetic process
GO:0006703 IEA:UniProtKB-UniPathway P estrogen biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 7
Protein Entry
DHB7_RAT
UniProt ID
Q62904
Species
Rat

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic Activity A 3-beta-hydroxysteroid + NADP(+) = a 3- oxosteroid + NADPH.
Function Responsible for the reduction of the keto group on the C-3 of sterols.
Pathway Steroid biosynthesis; estrogen biosynthesis.
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
Ptm Phosphorylated.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily
Subcellular Location Cell membrane; Single-pass membrane protein.
Subunit Binds to the short form of prolactin receptor.
Tissue Specificity Most abundant in ovaries of pregnant animals.

Identical and Related Proteins

Unique RefSeq proteins for LMP012606 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393576 RefSeq NP_058931 334 3-keto-steroid reductase

Identical Sequences to LMP012606 proteins

Reference Database Accession Length Protein Name
GI:8393576 GenBank AAC52623.1 334 ovarian-specific protein [Rattus norvegicus]
GI:8393576 GenBank ABI05597.1 334 Sequence 43 from patent US 7078169
GI:8393576 SwissProt Q62904.1 334 RecName: Full=3-keto-steroid reductase; AltName: Full=17-beta-hydroxysteroid dehydrogenase 7; Short=17-beta-HSD 7; AltName: Full=Estradiol 17-beta-dehydrogenase 7; AltName: Full=PRL receptor-associated protein; Short=PRAP [Rattus norvegicus]

Related Sequences to LMP012606 proteins

Reference Database Accession Length Protein Name
GI:8393576 GenBank AAC52623.1 334 ovarian-specific protein [Rattus norvegicus]
GI:8393576 GenBank ABI05597.1 334 Sequence 43 from patent US 7078169
GI:8393576 SwissProt Q62904.1 334 RecName: Full=3-keto-steroid reductase; AltName: Full=17-beta-hydroxysteroid dehydrogenase 7; Short=17-beta-HSD 7; AltName: Full=Estradiol 17-beta-dehydrogenase 7; AltName: Full=PRL receptor-associated protein; Short=PRAP [Rattus norvegicus]