Gene/Proteome Database (LMPD)

LMPD ID
LMP012608
Gene ID
29552
Species
Rattus norvegicus (Rat)
Gene Name
lipocalin 5
Gene Symbol
Lcn5
Synonyms
Erabp;
Alternate Names
epididymal-specific lipocalin-5; ESP-I; E-RABP; epididymal secretory protein I; epididymal retinoic acid-binding protein; androgen-dependent epididymal 18.5 kDa protein;
Chromosome
3
Map Location
3p13
Summary
has a low galactosyltransferase modifying activity in vitro; however, this activity is predicted to be too low for physiological significance [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lcn5

Proteins

epididymal-specific lipocalin-5 precursor
Refseq ID NP_077050
Protein GI 13162312
UniProt ID P06911
mRNA ID NM_024136
Length 188
MENIMPFALLGLCVGLAAGTEGAVVKDFDISKFLGFWYEIAFASKMGTPGLAHKEEKMGAMVVELKENLLALTTTYYSEDHCVLEKVTATEGDGPAKFQVTRLSGKKEVVVEATDYLTYAIIDITSLVAGAVHRTMKLYSRSLDDNGEALYNFRKITSDHGFSETDLYILKHDLTCVKVLQSAAESRP
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1920 peptide sequence: MENIMPFALLGLCVGLAAG

Gene Information

Entrez Gene ID
29552
Gene Name
lipocalin 5
Gene Symbol
Lcn5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:RGD C extracellular region
GO:0005215 IEA:InterPro F transporter activity
GO:0006629 IEA:InterPro P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR022272 Lipocalin family conserved site
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002972 Prostaglandin D synthase

UniProt Annotations

Entry Information

Gene Name
lipocalin 5
Protein Entry
LCN5_RAT
UniProt ID
P06911
Species
Rat

Comments

Comment Type Description
Function Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 9-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation.
Ptm The N-terminus of form C is probably blocked.
Ptm There are two similar, immunologically cross-reacting forms of this protein, designated B and C, which probably result from different processing of the amino end.
Similarity Belongs to the calycin superfamily. Lipocalin family
Subcellular Location Secreted. Note=Synthesized in the proximal part of the epididymis and secreted into the epididymal fluid.
Tissue Specificity Synthesized exclusively in the proximal part (caput epididymidis) of the epididymis. It makes up a substantial part of the total protein in the epididymal luminal fluid and binds to the sperm membrane.

Identical and Related Proteins

Unique RefSeq proteins for LMP012608 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13162312 RefSeq NP_077050 188 epididymal-specific lipocalin-5 precursor

Identical Sequences to LMP012608 proteins

Reference Database Accession Length Protein Name
GI:13162312 GenBank AAE50170.1 188 Sequence 14 from patent US 6114123
GI:13162312 GenBank AAM56508.1 188 Sequence 30 from patent US 6365716
GI:13162312 GenBank EDL93549.1 188 epididymal retinoic acid-binding protein, isoform CRA_a [Rattus norvegicus]
GI:13162312 RefSeq XP_008759802.1 188 PREDICTED: epididymal-specific lipocalin-5 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012608 proteins

Reference Database Accession Length Protein Name
GI:13162312 EMBL CAA42493.1 188 epididymal secretory protein I (ESP I) [Rattus norvegicus]
GI:13162312 GenBank AAM56508.1 188 Sequence 30 from patent US 6365716
GI:13162312 RefSeq XP_008759802.1 188 PREDICTED: epididymal-specific lipocalin-5 isoform X1 [Rattus norvegicus]