Gene/Proteome Database (LMPD)

LMPD ID
LMP012614
Gene ID
29602
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin F2 receptor inhibitor
Gene Symbol
Ptgfrn
Alternate Names
prostaglandin F2 receptor negative regulator; prostaglandin F2-alpha receptor regulatory protein; prostaglandin F2-alpha receptor-associated protein;
Chromosome
2
Map Location
2q34
Summary
binds prostaglandin F2 alpha and inhibits its binding to the prostaglandin F2 alpha receptor [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ptgfrn

Proteins

prostaglandin F2 receptor negative regulator precursor
Refseq ID NP_062116
Protein GI 9507007
UniProt ID Q62786
mRNA ID NM_019243
Length 879
MGRPAPRPLLLALLSLAVCRGRVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSSGSSFVELASTWEVGFPAQQYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTMQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTHLALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSADQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCNITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLVRDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGFSDDPTELQCRVIDTKRVDAGVRLTVSWYYRMNRRNDDVVASELLAVMDGDWTLRYGERSKQRAQDGEFIFSKEHTDTFSFRIQRTTEEDRGSYYCVVSAWTRQRNSSWVKSKDVFSKPVNIFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPIGGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTLSVTRGDLIKLFCIVTVDGAVLDPDDMAFDVSWFAVHSFGLDKAPILLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQVHSSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2205 peptide sequence: MGRPAPRPLLLALLSLAVCRG mat_peptide: 22..879 product: prostaglandin F2 receptor negative regulator note: mature protein molecular weight: 133 kDa calculated_mol_wt: 96544 peptide sequence: RVVRVPAGTLVRVVGTELVIPCNVSDYDGPSEQNFDWSFSSSGSSFVELASTWEVGFPAQQYRERLQRGDILLRRTANDAVELHIKNVQPSDQGHYKCSTPSTDATVQGNYEDTMQVKVLADALVVGPSSRPPPGLSLREGEPFELRCIASTTSPLHTHLALRWELHRGPVHRSILALSHEGRFHPGPGYEQRYHSGDVRLDTVGSDAYRLSVARALSADQGSYRCVVSEWITEQGSWQEIQEKAVEVATVVIQPTALQLAVPRTVSVTEGKDLDLSCNITTDRVDDVRPEVTWYFKKTPDTSLLASHMLARLDRDSLVHSSPHVALSHVDTRSYHLLVRDVSKENSGYYLCLVALWAPGHNRSWHKVAEAMSAPSGVSVTWLEPEYQVYLNASKVPGFSDDPTELQCRVIDTKRVDAGVRLTVSWYYRMNRRNDDVVASELLAVMDGDWTLRYGERSKQRAQDGEFIFSKEHTDTFSFRIQRTTEEDRGSYYCVVSAWTRQRNSSWVKSKDVFSKPVNIFWASEDSVLVVKARQPKPFFAAGNTFEMTCKVSSKNIKSPRYSVLITAEKPVGDLSSPNETKYIISLDQDSVVKLENWTDASRVDGVVLEKVQEDEFRYRMYQTQVSDAGLYRCMVTAWSPIGGSLWREAATSLSNPIEIDFQTSGPIFNASVHSDTLSVTRGDLIKLFCIVTVDGAVLDPDDMAFDVSWFAVHSFGLDKAPILLSSLDRKGVVTTGQRDWKSTVSLERVSVLEFLLQVHSSEDQDFGNYYCSVTPWVRSPTGSWQREAEIHSRPIFITVKMDVLNAFKYPLLIGVGLSTVIGLLSCLIGYCSSHWCCKKEVRETRRERRRLMSMEMD

Gene Information

Entrez Gene ID
29602
Gene Name
prostaglandin F2 receptor inhibitor
Gene Symbol
Ptgfrn
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0017148 NAS:UniProtKB P negative regulation of translation

Domain Information

InterPro Annotations

Accession Description
IPR013106 Immunoglobulin V-set domain
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold

UniProt Annotations

Entry Information

Gene Name
prostaglandin F2 receptor inhibitor
Protein Entry
FPRP_RAT
UniProt ID
Q62786
Species
Rat

Comments

Comment Type Description
Function Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur.
Similarity Contains 6 Ig-like C2-type (immunoglobulin-like) domains
Subcellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Subunit Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151 (By similarity)
Tissue Specificity Reproductive tissues, lung and heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP012614 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9507007 RefSeq NP_062116 879 prostaglandin F2 receptor negative regulator precursor

Identical Sequences to LMP012614 proteins

Reference Database Accession Length Protein Name
GI:9507007 GenBank AAC18426.1 879 prostaglandin F2a receptor regulatory protein precursor [Rattus norvegicus]
GI:9507007 SwissProt Q62786.1 879 RecName: Full=Prostaglandin F2 receptor negative regulator; AltName: Full=Prostaglandin F2-alpha receptor regulatory protein; AltName: Full=Prostaglandin F2-alpha receptor-associated protein; AltName: CD_antigen=CD315; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012614 proteins

Reference Database Accession Length Protein Name
GI:9507007 GenBank AAC18426.1 879 prostaglandin F2a receptor regulatory protein precursor [Rattus norvegicus]
GI:9507007 pat US 879 Sequence 1 from patent US 5747660
GI:9507007 SwissProt Q62786.1 879 RecName: Full=Prostaglandin F2 receptor negative regulator; AltName: Full=Prostaglandin F2-alpha receptor regulatory protein; AltName: Full=Prostaglandin F2-alpha receptor-associated protein; AltName: CD_antigen=CD315; Flags: Precursor [Rattus norvegicus]