Gene/Proteome Database (LMPD)
LMPD ID
LMP012617
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
arachidonate 5-lipoxygenase activating protein
Gene Symbol
Alternate Names
arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein; 5-lipoxygenase-activating protein FLAP;
Chromosome
12
Map Location
12p11
Summary
involved in leukotriene synthesis; plays a role in immediate hypersensitivity response [RGD, Feb 2006]
Orthologs
Proteins
Gene Information
Entrez Gene ID
Gene Name
arachidonate 5-lipoxygenase activating protein
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:RGD | C | cytosol |
| GO:0005783 | IDA:RGD | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | TAS:RGD | C | membrane |
| GO:0005635 | ISS:UniProtKB | C | nuclear envelope |
| GO:0031965 | ISS:UniProtKB | C | nuclear membrane |
| GO:0050544 | ISS:UniProtKB | F | arachidonic acid binding |
| GO:0008047 | IEA:InterPro | F | enzyme activator activity |
| GO:0019899 | IPI:RGD | F | enzyme binding |
| GO:0046982 | IPI:RGD | F | protein heterodimerization activity |
| GO:0042803 | IDA:RGD | F | protein homodimerization activity |
| GO:0071277 | IEA:Ensembl | P | cellular response to calcium ion |
| GO:0019370 | IDA:RGD | P | leukotriene biosynthetic process |
| GO:0002540 | IEA:Ensembl | P | leukotriene production involved in inflammatory response |
| GO:0019372 | IDA:RGD | P | lipoxygenase pathway |
| GO:0055114 | IDA:GOC | P | oxidation-reduction process |
| GO:0002675 | IMP:RGD | P | positive regulation of acute inflammatory response |
| GO:0070207 | IDA:RGD | P | protein homotrimerization |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
arachidonate 5-lipoxygenase activating protein
Protein Entry
AL5AP_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Domain | The C-terminal part after residue 140 is mostly disordered |
| Function | Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. unstructured (By similarity) |
| Similarity | Belongs to the MAPEG family |
| Subcellular Location | Nucleus membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . |
| Subunit | Homotrimer. Interacts with LTC4S and ALOX5 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012617 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 8392897 | RefSeq | NP_058956 | 161 | arachidonate 5-lipoxygenase-activating protein |
Identical Sequences to LMP012617 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:8392897 | GenBank | AAH86593.1 | 161 | Arachidonate 5-lipoxygenase activating protein [Rattus norvegicus] |
| GI:8392897 | GenBank | EDL89525.1 | 161 | arachidonate 5-lipoxygenase activating protein [Rattus norvegicus] |
| GI:8392897 | GenBank | AEK13630.1 | 161 | Sequence 42 from patent US 7972785 |
| GI:8392897 | SwissProt | P20291.2 | 161 | RecName: Full=Arachidonate 5-lipoxygenase-activating protein; AltName: Full=FLAP; AltName: Full=MK-886-binding protein [Rattus norvegicus] |
Related Sequences to LMP012617 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:8392897 | GenBank | AAH86593.1 | 161 | Arachidonate 5-lipoxygenase activating protein [Rattus norvegicus] |
| GI:8392897 | GenBank | AEK13630.1 | 161 | Sequence 42 from patent US 7972785 |
| GI:8392897 | PRF | - | 161 | lipoxygenase activating protein [Rattus norvegicus] |