Gene/Proteome Database (LMPD)

LMPD ID
LMP012622
Gene ID
29653
Species
Rattus norvegicus (Rat)
Gene Name
glycerol-3-phosphate acyltransferase, mitochondrial
Gene Symbol
Gpam
Alternate Names
glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT-1;
Chromosome
1
Map Location
1q55
EC Number
2.3.1.15
Summary
mitochondrial glycerol-phosphate acyltransferase enzyme; regulated by phosphorylation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gpam

Proteins

glycerol-3-phosphate acyltransferase 1, mitochondrial
Refseq ID NP_058970
Protein GI 8393466
UniProt ID P97564
mRNA ID NM_017274
Length 828
MEESSVTIGTIDVSYLPNSSEYSLGRCKHTNEDWVDCGFKPTFFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYILFVQERDVHKGMFATSITDNVLNSSRVQEAIAEVAAELNPDGSAQQQSKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDILYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLEGQSQKPVSAPLSLEQALLPAILPSRPDAAAAEHEDMSSNESRNAADEAFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSIYAVQNKRGSGGSAGGLGNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCQETVGKFIQYGILTVAEQDDQEDVSPGLAEQQWNKKLPEPLNWRSDEEDEDSDFGEEQRDCYLKVSQAKEHQQFITFLQRLLGPLLEAYSSAAIFVHTFRGPVPESEYLQKLHRYLLTRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRASVLELSTTFLPQGSRQKLLEYILSFVVL

Gene Information

Entrez Gene ID
29653
Gene Name
glycerol-3-phosphate acyltransferase, mitochondrial
Gene Symbol
Gpam
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0031966 IDA:RGD C mitochondrial membrane
GO:0005741 IDA:RGD C mitochondrial outer membrane
GO:0005739 TAS:RGD C mitochondrion
GO:0005886 IEA:InterPro C plasma membrane
GO:0004366 IDA:RGD F glycerol-3-phosphate O-acyltransferase activity
GO:0016024 IEA:UniProtKB-UniPathway P CDP-diacylglycerol biosynthetic process
GO:0032869 IDA:RGD P cellular response to insulin stimulus
GO:0010867 IDA:RGD P positive regulation of triglyceride biosynthetic process
GO:0014823 IDA:RGD P response to activity
GO:0046686 IEP:RGD P response to cadmium ion
GO:0009750 IEP:RGD P response to fructose
GO:0031667 IEP:RGD P response to nutrient levels

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
M00089 Triacylglycerol biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5953472 Synthesis of PA
5953464 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate acyltransferase, mitochondrial
Protein Entry
GPAT1_RAT
UniProt ID
P97564
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate
Function Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
Sequence Caution Sequence=AAB39470.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the GPAT/DAPAT family
Subcellular Location Mitochondrion outer membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012622 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393466 RefSeq NP_058970 828 glycerol-3-phosphate acyltransferase 1, mitochondrial

Identical Sequences to LMP012622 proteins

Reference Database Accession Length Protein Name
GI:8393466 GenBank AAB71605.1 828 sn-glycerol-3-phosphate acyltransferase [Rattus norvegicus]
GI:8393466 SwissProt P97564.3 828 RecName: Full=Glycerol-3-phosphate acyltransferase 1, mitochondrial; Short=GPAT-1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012622 proteins

Reference Database Accession Length Protein Name
GI:8393466 GenBank AAB71605.1 828 sn-glycerol-3-phosphate acyltransferase [Rattus norvegicus]
GI:8393466 GenBank EDL94452.1 828 glycerol-3-phosphate acyltransferase, mitochondrial, isoform CRA_a [Rattus norvegicus]
GI:8393466 SwissProt P97564.3 828 RecName: Full=Glycerol-3-phosphate acyltransferase 1, mitochondrial; Short=GPAT-1; Flags: Precursor [Rattus norvegicus]