Gene/Proteome Database (LMPD)

LMPD ID
LMP012623
Gene ID
29680
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Gene Symbol
Cyp11a1
Synonyms
Cyp11a; Cypxia1; P450scc;
Alternate Names
cholesterol side-chain cleavage enzyme, mitochondrial; P450(scc); cytochrome P450 11A1; cytochrome P450(scc); cholesterol desmolase; cytochrome P450 subfamily 11A; cytochrome P450 side-chain cleavage enzyme; cholesterol side-chain cleavage cytochrome P450; cytochrome P450 11a cholesterol side chain cleavage;
Chromosome
8
Map Location
8q24
EC Number
1.14.15.6
Summary
monooxygenase that catalyzes synthesis of cholesterol and steroids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp11a1

Proteins

cholesterol side-chain cleavage enzyme, mitochondrial precursor
Refseq ID NP_058982
Protein GI 8393224
UniProt ID P14137
mRNA ID NM_017286
Length 526
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
transit_peptide: 1..36 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (P14137.1) calculated_mol_wt: 3657 peptide sequence: MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAG mat_peptide: 37..526 product: Cholesterol side-chain cleavage enzyme, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P14137.1) calculated_mol_wt: 56947 peptide sequence: ISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV

Gene Information

Entrez Gene ID
29680
Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Gene Symbol
Cyp11a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030061 IDA:RGD C mitochondrial crista
GO:0005743 IDA:RGD C mitochondrial inner membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0043204 IDA:RGD C perikaryon
GO:0015485 IMP:RGD F cholesterol binding
GO:0008386 IMP:RGD F cholesterol monooxygenase (side-chain-cleaving) activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0006700 IDA:RGD P C21-steroid hormone biosynthetic process
GO:0033327 IEP:RGD P Leydig cell differentiation
GO:0014037 IEP:RGD P Schwann cell differentiation
GO:0018879 IEP:RGD P biphenyl metabolic process
GO:0071236 IEP:RGD P cellular response to antibiotic
GO:0071320 IEP:RGD P cellular response to cAMP
GO:0071276 IEP:RGD P cellular response to cadmium ion
GO:0044344 IEP:RGD P cellular response to fibroblast growth factor stimulus
GO:0071372 IEP:RGD P cellular response to follicle-stimulating hormone stimulus
GO:0071371 IEP:RGD P cellular response to gonadotropin stimulus
GO:0071347 IEP:RGD P cellular response to interleukin-1
GO:0071222 IEP:RGD P cellular response to lipopolysaccharide
GO:0071375 IEP:RGD P cellular response to peptide hormone stimulus
GO:0071560 IEP:RGD P cellular response to transforming growth factor beta stimulus
GO:0071356 IEP:RGD P cellular response to tumor necrosis factor
GO:0021549 IEP:RGD P cerebellum development
GO:0008203 ISS:UniProtKB P cholesterol metabolic process
GO:0018894 IEP:RGD P dibenzo-p-dioxin metabolic process
GO:0006703 IEP:RGD P estrogen biosynthetic process
GO:0050756 IEP:RGD P fractalkine metabolic process
GO:0060014 IEP:RGD P granulosa cell differentiation
GO:0021766 IEP:RGD P hippocampus development
GO:0008584 IEP:RGD P male gonad development
GO:0060135 IEP:RGD P maternal process involved in female pregnancy
GO:0007617 IMP:RGD P mating behavior
GO:0006082 IEP:RGD P organic acid metabolic process
GO:0018958 IEP:RGD P phenol-containing compound metabolic process
GO:0018963 IEP:RGD P phthalate metabolic process
GO:0006701 IEP:RGD P progesterone biosynthetic process
GO:0033591 IEP:RGD P response to L-ascorbic acid
GO:0043279 IEP:RGD P response to alkaloid
GO:0043200 IEP:RGD P response to amino acid
GO:0046677 IEP:RGD P response to antibiotic
GO:0051591 IEP:RGD P response to cAMP
GO:0046686 IEP:RGD P response to cadmium ion
GO:0051412 IEP:RGD P response to corticosterone
GO:0042493 IEP:RGD P response to drug
GO:0043627 IEP:RGD P response to estrogen
GO:0060992 IEP:RGD P response to fungicide
GO:0010332 IEP:RGD P response to gamma radiation
GO:0033595 IEP:RGD P response to genistein
GO:0034698 IEP:RGD P response to gonadotropin
GO:0042542 IMP:RGD P response to hydrogen peroxide
GO:0017085 IEP:RGD P response to insecticide
GO:0010212 IEP:RGD P response to ionizing radiation
GO:0007584 IEP:RGD P response to nutrient
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010033 IEP:RGD P response to organic substance
GO:0043434 IEP:RGD P response to peptide hormone
GO:0009651 IEP:RGD P response to salt stress
GO:0048545 IEP:RGD P response to steroid hormone
GO:0033197 IEP:RGD P response to vitamin E
GO:0006694 IMP:RGD P steroid biosynthetic process
GO:0061370 IEP:RGD P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis
M00107 Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone

REACTOME Pathway Links

REACTOME Pathway ID Description
5953258 Biological oxidations
5953485 Cytochrome P450 - arranged by substrate type
5953932 Endogenous sterols
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953937 Metabolism of steroid hormones and vitamin D
5953326 Phase 1 - Functionalization of compounds
5953939 Pregnenolone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 11, subfamily a, polypeptide 1
Protein Entry
CP11A_RAT
UniProt ID
P14137
Species
Rat

Comments

Comment Type Description
Catalytic Activity Cholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone
Induction Induced by FSH or pregnant mare's serum gonadotropin in ovaries of estrogen-treated immature rats in vivo.
Pathway Lipid metabolism; C21-steroid hormone metabolism.
Similarity Belongs to the cytochrome P450 family
Subcellular Location Mitochondrion membrane.
Subunit Interacts with FDX1/adrenodoxin
Tissue Specificity Expressed in ovary, adrenal and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012623 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393224 RefSeq NP_058982 526 cholesterol side-chain cleavage enzyme, mitochondrial precursor

Identical Sequences to LMP012623 proteins

Reference Database Accession Length Protein Name
GI:8393224 GenBank AAA40958.1 526 cytochrome P-450-scc [Rattus norvegicus]
GI:8393224 GenBank AAA40989.1 526 cholesterol side-chain cleavage enzyme precursor (EC 1.14.15.6) [Rattus norvegicus]
GI:8393224 GenBank AAH89100.1 526 Cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:8393224 GenBank EDL95659.1 526 cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]

Related Sequences to LMP012623 proteins

Reference Database Accession Length Protein Name
GI:8393224 GenBank AAH89100.1 526 Cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:8393224 GenBank EDL95659.1 526 cytochrome P450, family 11, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:8393224 SwissProt P14137.1 526 RecName: Full=Cholesterol side-chain cleavage enzyme, mitochondrial; AltName: Full=CYPXIA1; AltName: Full=Cholesterol desmolase; AltName: Full=Cytochrome P450 11A1; AltName: Full=Cytochrome P450(scc); Flags: Precursor [Rattus norvegicus]