Gene/Proteome Database (LMPD)

LMPD ID
LMP012624
Gene ID
29688
Species
Rattus norvegicus (Rat)
Gene Name
multiple inositol-polyphosphate phosphatase 1
Gene Symbol
Minpp1
Alternate Names
multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; multiple inositol polyphosphate histidine phosphatase 1;
Chromosome
1
Map Location
1q52
EC Number
3.1.3.62
Summary
catalyzes the hydrolysis of Ins(1,3,4,5,6)P5, first to Ins(1,4,5,6)P4 and then to Ins(1,4,5)P3, by consecutive 3- and 6-phosphatase activities [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Minpp1

Proteins

multiple inositol polyphosphate phosphatase 1 precursor
Refseq ID NP_062136
Protein GI 158749647
UniProt ID O35217
mRNA ID NM_019263
Length 481
MLRGARSHLSASVALAAVLAAALLSSFARCSLPGRGDPVASVLSPYFGTKTRYEDVNPWLLGDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRKLRQLQGLLQTRESVDGGSRVAAALDQWPLWYDDWMDGQLVEKGRQDMRQLALRLAALFPDLFCRENYGRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDVSDMECDPPRVNDKLMRFFDHCEKFLTEVERNATALYHVEAFKTGPEMQTVLKKVAATLQVPVNNLNADLIQVAFFTCSFDLAIQGVHSPWCDVFDVDDAKVLEYLNDLKQYWKRSYGYAINSRSSCNLFQDIFLHLDKAVEQKQRSQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQVHREFRSGHIVPYASNLIFVLYHCEDAQTPQEKFQIQMLLNEKVLPLAHSQKTVALYEDLKNHYQDILQSCQTSKECNLPKVNITSDEL
sig_peptide: 1..30 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3015 peptide sequence: MLRGARSHLSASVALAAVLAAALLSSFARC mat_peptide: 31..481 product: Multiple inositol polyphosphate phosphatase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35217.3) calculated_mol_wt: 51603 peptide sequence: SLPGRGDPVASVLSPYFGTKTRYEDVNPWLLGDPVAPRRDPELLAGTCTPVQLVALIRHGTRYPTTKQIRKLRQLQGLLQTRESVDGGSRVAAALDQWPLWYDDWMDGQLVEKGRQDMRQLALRLAALFPDLFCRENYGRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDVSDMECDPPRVNDKLMRFFDHCEKFLTEVERNATALYHVEAFKTGPEMQTVLKKVAATLQVPVNNLNADLIQVAFFTCSFDLAIQGVHSPWCDVFDVDDAKVLEYLNDLKQYWKRSYGYAINSRSSCNLFQDIFLHLDKAVEQKQRSQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNFEEQVHREFRSGHIVPYASNLIFVLYHCEDAQTPQEKFQIQMLLNEKVLPLAHSQKTVALYEDLKNHYQDILQSCQTSKECNLPKVNITSDEL

Gene Information

Entrez Gene ID
29688
Gene Name
multiple inositol-polyphosphate phosphatase 1
Gene Symbol
Minpp1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0003993 IEA:InterPro F acid phosphatase activity
GO:0034417 IEA:UniProtKB-EC F bisphosphoglycerate 3-phosphatase activity
GO:0052826 IEA:UniProtKB-EC F inositol hexakisphosphate 2-phosphatase activity
GO:0030351 IDA:RGD F inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
GO:0030352 IDA:RGD F inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
GO:0016311 IDA:GOC P dephosphorylation
GO:0048015 NAS:RGD P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954519 Synthesis of IPs in the ER lumen

Domain Information

InterPro Annotations

Accession Description
IPR016274 Histidine acid phosphatase, eukaryotic
IPR029033 Histidine phosphatase superfamily
IPR000560 Histidine phosphatase superfamily, clade-2

UniProt Annotations

Entry Information

Gene Name
multiple inositol-polyphosphate phosphatase 1
Protein Entry
MINP1_RAT
UniProt ID
O35217
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=6.9 uM for Ins(1,3,4,5)P(4) ; Vmax=302 pmol/min/ug enzyme ;
Catalytic Activity 2,3-bisphospho-D-glycerate + H(2)O = 2- phospho-D-glycerate + phosphate
Catalytic Activity Myo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate
Function Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification)
Similarity Belongs to the histidine acid phosphatase family. MINPP1 subfamily
Subcellular Location Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:8384201}.
Tissue Specificity Widely expressed with highest levels in kidney and liver. Expressed in chondrocytes with an elevated expression in hypertrophic chondrocytes. {ECO:0000269|PubMed:9359836, ECO:0000269|PubMed:9923613}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012624 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158749647 RefSeq NP_062136 481 multiple inositol polyphosphate phosphatase 1 precursor

Identical Sequences to LMP012624 proteins

Reference Database Accession Length Protein Name
GI:158749647 GenBank EDM13138.1 481 rCG47320 [Rattus norvegicus]

Related Sequences to LMP012624 proteins

Reference Database Accession Length Protein Name
GI:158749647 GenBank AAC53453.2 481 hepatic multiple inositol polyphosphate phosphatase [Rattus norvegicus]
GI:158749647 GenBank EDM13138.1 481 rCG47320 [Rattus norvegicus]
GI:158749647 SwissProt O35217.3 481 RecName: Full=Multiple inositol polyphosphate phosphatase 1; AltName: Full=2,3-bisphosphoglycerate 3-phosphatase; Short=2,3-BPG phosphatase; AltName: Full=Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Short=Ins(1,3,4,5)P(4) 3-phosphatase; Flags: Precursor [Rattus norvegicus]