Gene/Proteome Database (LMPD)

LMPD ID
LMP012625
Gene ID
29692
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Gene Symbol
Pla2g2a
Synonyms
sPLA2;
Alternate Names
phospholipase A2, membrane associated; GIIC sPLA2; platelet phospholipase A2; group IIA phospholipase A2; eted enzyme type IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A;
Chromosome
5
Map Location
5q36
EC Number
3.1.1.4
Summary
hydrolyzes acyl group at the sn-2 position of phospholipids, forming non-esterified fatty acids and lysophospholipids; plays a critical role in inflammation; induces proliferation of smooth muscle cells [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pla2g2a

Proteins

phospholipase A2, membrane associated precursor
Refseq ID NP_113786
Protein GI 291621686
UniProt ID P14423
mRNA ID NM_031598
Length 146
MKVLLLLAVVIMAFGSIQVQGSLLEFGQMILFKTGKRADVSYGFYGCHCGVGGRGSPKDATDWCCVTHDCCYNRLEKRGCGTKFLTYKFSYRGGQISCSTNQDSCRKQLCQCDKAAAECFARNKKSYSLKYQFYPNKFCKGKTPSC
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2231 peptide sequence: MKVLLLLAVVIMAFGSIQVQG mat_peptide: 22..146 product: Phospholipase A2, membrane associated experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P14423.2) calculated_mol_wt: 14081 peptide sequence: SLLEFGQMILFKTGKRADVSYGFYGCHCGVGGRGSPKDATDWCCVTHDCCYNRLEKRGCGTKFLTYKFSYRGGQISCSTNQDSCRKQLCQCDKAAAECFARNKKSYSLKYQFYPNKFCKGKTPSC

Gene Information

Entrez Gene ID
29692
Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Gene Symbol
Pla2g2a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0005615 IEA:Ensembl C extracellular space
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0030141 IDA:RGD C secretory granule
GO:0005509 IEA:InterPro F calcium ion binding
GO:0047498 IDA:RGD F calcium-dependent phospholipase A2 activity
GO:0004623 TAS:RGD F phospholipase A2 activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0016042 TAS:RGD P lipid catabolic process
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0046473 IEA:Ensembl P phosphatidic acid metabolic process
GO:0006644 IDA:RGD P phospholipid metabolic process
GO:0035019 IEA:Ensembl P somatic stem cell maintenance

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko00591 Linoleic acid metabolism
rno00591 Linoleic acid metabolism
rno01100 Metabolic pathways
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
rno04014 Ras signaling pathway
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954464 Acyl chain remodelling of PC
5954471 Acyl chain remodelling of PE
5954465 Acyl chain remodelling of PG
5954468 Acyl chain remodelling of PI
5954470 Acyl chain remodelling of PS
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5953472 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR001211 Phospholipase A2
IPR016090 Phospholipase A2 domain
IPR013090 Phospholipase A2, active site

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IIA (platelets, synovial fluid)
Protein Entry
PA2GA_RAT
UniProt ID
P14423
Species
Rat

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ;
Function Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
Miscellaneous Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.
Similarity Belongs to the phospholipase A2 family
Subcellular Location Membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012625 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
291621686 RefSeq NP_113786 146 phospholipase A2, membrane associated precursor

Identical Sequences to LMP012625 proteins

Reference Database Accession Length Protein Name
GI:291621686 DBBJ BAA00410.1 146 phospholipase A2 precursor [Rattus norvegicus]
GI:291621686 GenBank EDL80890.1 146 phospholipase A2, group IIA (platelets, synovial fluid), isoform CRA_a [Rattus norvegicus]
GI:291621686 GenBank AEU43268.1 146 Sequence 17 from patent US 8052970
GI:291621686 RefSeq XP_006239208.1 146 PREDICTED: phospholipase A2, membrane associated isoform X1 [Rattus norvegicus]

Related Sequences to LMP012625 proteins

Reference Database Accession Length Protein Name
GI:291621686 GenBank EDL80890.1 146 phospholipase A2, group IIA (platelets, synovial fluid), isoform CRA_a [Rattus norvegicus]
GI:291621686 RefSeq XP_006239208.1 146 PREDICTED: phospholipase A2, membrane associated isoform X1 [Rattus norvegicus]
GI:291621686 SwissProt P14423.2 146 RecName: Full=Phospholipase A2, membrane associated; AltName: Full=GIIC sPLA2; AltName: Full=Group IIA phospholipase A2; AltName: Full=Phosphatidylcholine 2-acylhydrolase 2A; Flags: Precursor [Rattus norvegicus]