Gene/Proteome Database (LMPD)

LMPD ID
LMP012629
Gene ID
29726
Species
Rattus norvegicus (Rat)
Gene Name
solute carrier family 22 (organic cation/carnitine transporter), member 5
Gene Symbol
Slc22a5
Synonyms
CT1; OCTN2; UST2r;
Alternate Names
solute carrier family 22 member 5; solute carrier family 22, member 5; high-affinity carnitine transporter; integral membrane transport protein; organic cation/carnitine transporter 2; high-affinity sodium-dependent carnitine cotransporter; solute carrier family 22 (organic cation transporter), member 5;
Chromosome
10
Map Location
10q22
Summary
mediates high-affinity sodium-dependent carnitine transport and sodium-independent organic cation transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Slc22a5

Proteins

solute carrier family 22 member 5
Refseq ID NP_062142
Protein GI 9507119
UniProt ID O70594
mRNA ID NM_019269
Length 557
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGAPLPDTIDQMLRVKGIKQWQIQSQTRTQKDGGESPTVLKSTAF

Gene Information

Entrez Gene ID
29726
Gene Name
solute carrier family 22 (organic cation/carnitine transporter), member 5
Gene Symbol
Slc22a5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016324 IEA:Ensembl C apical plasma membrane
GO:0016323 IDA:RGD C basolateral plasma membrane
GO:0031526 IEA:Ensembl C brush border membrane
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 NAS:RGD C integral component of membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042895 IMP:RGD F antibiotic transporter activity
GO:0015226 IDA:RGD F carnitine transmembrane transporter activity
GO:0015651 IDA:RGD F quaternary ammonium group transmembrane transporter activity
GO:0015293 IEA:UniProtKB-KW F symporter activity
GO:0042891 IMP:RGD P antibiotic transport
GO:1902603 IDA:GOC P carnitine transmembrane transport
GO:0015879 IDA:RGD P carnitine transport
GO:0060731 IEA:Ensembl P positive regulation of intestinal epithelial structure maintenance
GO:0015697 IDA:RGD P quaternary ammonium group transport
GO:0052106 IEA:Ensembl P quorum sensing involved in interaction with host
GO:0006814 IEA:UniProtKB-KW P sodium ion transport
GO:0070715 IEA:Ensembl P sodium-dependent organic cation transport

REACTOME Pathway Links

REACTOME Pathway ID Description
5954330 Organic cation transport
5954331 Organic cation/anion/zwitterion transport
5953264 SLC-mediated transmembrane transport
5953265 Transmembrane transport of small molecules
5953895 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Domain Information

InterPro Annotations

Accession Description
IPR005828 General substrate transporter
IPR020846 Major facilitator superfamily domain
IPR004749 Organic cation transport protein
IPR005829 Sugar transporter, conserved site

UniProt Annotations

Entry Information

Gene Name
solute carrier family 22 (organic cation/carnitine transporter), member 5
Protein Entry
S22A5_RAT
UniProt ID
O70594
Species
Rat

Comments

Comment Type Description
Function Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Similarity Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family
Subcellular Location Membrane; Multi-pass membrane protein.
Subunit Interacts with PDZK1
Tissue Specificity Expressed in the proximal and distal tubules and in the glomeruli in the kidney, in the myocardium, valves, and arterioles in the heart, in the labyrinthine layer of the placenta, and in the cortex, hippocampus, and cerebellum in the brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP012629 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9507119 RefSeq NP_062142 557 solute carrier family 22 member 5

Identical Sequences to LMP012629 proteins

Reference Database Accession Length Protein Name
GI:9507119 EMBL CAA05106.1 557 putative integral membrane transport protein [Rattus norvegicus]
GI:9507119 GenBank AAD54059.1 557 organic cation/carnitine transporter [Rattus norvegicus]
GI:9507119 GenBank EDM04409.1 557 rCG35332, isoform CRA_b [Rattus norvegicus]
GI:9507119 SwissProt O70594.1 557 RecName: Full=Solute carrier family 22 member 5; AltName: Full=CT1; AltName: Full=High-affinity sodium-dependent carnitine cotransporter; AltName: Full=Organic cation/carnitine transporter 2; AltName: Full=UST2r [Rattus norvegicus]

Related Sequences to LMP012629 proteins

Reference Database Accession Length Protein Name
GI:9507119 EMBL CAA05106.1 557 putative integral membrane transport protein [Rattus norvegicus]
GI:9507119 GenBank AAD54059.1 557 organic cation/carnitine transporter [Rattus norvegicus]
GI:9507119 SwissProt O70594.1 557 RecName: Full=Solute carrier family 22 member 5; AltName: Full=CT1; AltName: Full=High-affinity sodium-dependent carnitine cotransporter; AltName: Full=Organic cation/carnitine transporter 2; AltName: Full=UST2r [Rattus norvegicus]