Gene/Proteome Database (LMPD)

LMPD ID
LMP012632
Gene ID
29741
Species
Rattus norvegicus (Rat)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Gene Symbol
Pik3r2
Alternate Names
phosphatidylinositol 3-kinase regulatory subunit beta; ptdIns-3-kinase p85-beta; PI3-kinase p85 subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulartory subunit polypeptide 2; phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta);
Chromosome
16
Map Location
16p14
Summary
regulatory subunit of the enzyme phosphatidylinositol 3-kinase; involved in cellular signaling mechanisms [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pik3r2

Proteins

phosphatidylinositol 3-kinase regulatory subunit beta
Refseq ID NP_071521
Protein GI 59709464
UniProt ID Q5FVS6
mRNA ID NM_022185
Length 722
MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGPSESGHTLASLAEQFSPPEPAPPILVKLIEAIEQAELDSECYSRPELPAPRTDWSLSDLEQWDRTTLYDAVKGFLLALPAAVVTPEAASEAYRAMREVTGPVGLVLEPPTLPLHQALTLQFLLQHLGRVARRAPSPATAVHALASAFGPLLLRAPPPGGEGDGSEPAPDFPVLLLERLVQEHVDEQDTAPPALPPKPSKVKPAPTALANGGSTPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQVVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR

Gene Information

Entrez Gene ID
29741
Gene Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Gene Symbol
Pik3r2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005942 IEA:InterPro C phosphatidylinositol 3-kinase complex
GO:0016303 IEA:Ensembl F 1-phosphatidylinositol-3-kinase activity
GO:0035014 IEA:InterPro F phosphatidylinositol 3-kinase regulator activity
GO:0007165 IEA:InterPro P signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko04960 Aldosterone-regulated sodium reabsorption
rno04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04210 Apoptosis
rno04210 Apoptosis
ko04662 B cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
ko05100 Bacterial invasion of epithelial cells
rno05100 Bacterial invasion of epithelial cells
ko04973 Carbohydrate digestion and absorption
rno04973 Carbohydrate digestion and absorption
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko05210 Colorectal cancer
rno05210 Colorectal cancer
ko05213 Endometrial cancer
rno05213 Endometrial cancer
ko05169 Epstein-Barr virus infection
rno05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
rno04068 FoxO signaling pathway
ko05214 Glioma
rno05214 Glioma
rno04066 HIF-1 signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
rno05161 Hepatitis B
ko05160 Hepatitis C
rno05160 Hepatitis C
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko05164 Influenza A
rno05164 Influenza A
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko04670 Leukocyte transendothelial migration
rno04670 Leukocyte transendothelial migration
ko05162 Measles
rno05162 Measles
ko05218 Melanoma
rno05218 Melanoma
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko05212 Pancreatic cancer
rno05212 Pancreatic cancer
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko04914 Progesterone-mediated oocyte maturation
rno04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05215 Prostate cancer
rno05215 Prostate cancer
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton
ko05211 Renal cell carcinoma
rno05211 Renal cell carcinoma
ko04550 Signaling pathways regulating pluripotency of stem cells
rno04550 Signaling pathways regulating pluripotency of stem cells
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko04660 T cell receptor signaling pathway
rno04660 T cell receptor signaling pathway
ko04668 TNF signaling pathway
rno04668 TNF signaling pathway
rno04919 Thyroid hormone signaling pathway
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko04930 Type II diabetes mellitus
rno04930 Type II diabetes mellitus
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway
ko04150 mTOR signaling pathway
rno04150 mTOR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5953650 Cell surface interactions at the vascular wall
5954063 Cell-Cell communication
5954570 Constitutive PI3K/AKT Signaling in Cancer
5953536 Cytokine Signaling in Immune system
5953408 DAP12 interactions
5953407 DAP12 signaling
5953253 Disease
5954035 Downstream TCR signaling
5953396 Downstream signal transduction
5953994 Downstream signaling events of B Cell Receptor (BCR)
5953399 Downstream signaling of activated FGFR
5953417 Fc epsilon receptor (FCERI) signaling
5953784 Fcgamma receptor (FCGR) dependent phagocytosis
5953884 GAB1 signalosome
5953645 Hemostasis
5953430 IGF1R signaling cascade
5953428 IRS-mediated signalling
5953425 IRS-related events
5953429 IRS-related events triggered by IGF1R
5953410 Immune System
5953409 Innate Immune System
5953422 Insulin receptor signalling cascade
5954308 Interleukin-7 signaling
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953394 NGF signalling via TRKA from the plasma membrane
5954128 Nephrin interactions
5954478 PI Metabolism
5953885 PI-3K cascade
5953432 PI3K Cascade
5953996 PI3K events in ERBB2 signaling
5953995 PI3K events in ERBB4 signaling
5953997 PI3K/AKT Signaling in Cancer
5953989 PI3K/AKT activation
5953993 PIP3 activates AKT signaling
5953474 Phospholipid metabolism
5953961 Rho GTPase cycle
5953998 Role of LAT2/NTAL/LAB on calcium mobilization
5953783 Role of phospholipids in phagocytosis
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953540 Signaling by ERBB4
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5953423 Signaling by Insulin receptor
5953535 Signaling by Interleukins
5953397 Signaling by PDGF
5953962 Signaling by Rho GTPases
5953541 Signaling by SCF-KIT
5953431 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953420 Signaling by VEGF
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF
5954499 Synthesis of PIPs at the plasma membrane
5954036 TCR signaling
5954054 Tie2 Signaling
5953419 VEGFA-VEGFR2 Pathway

Domain Information

InterPro Annotations

Accession Description
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Protein Entry
Q5FVS6_RAT
UniProt ID
Q5FVS6
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012632 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
59709464 RefSeq NP_071521 722 phosphatidylinositol 3-kinase regulatory subunit beta

Identical Sequences to LMP012632 proteins

Reference Database Accession Length Protein Name
GI:59709464 GenBank AAH89805.1 722 Phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Rattus norvegicus]
GI:59709464 GenBank EDL90737.1 722 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2, isoform CRA_a [Rattus norvegicus]
GI:59709464 RefSeq XP_008769318.1 722 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [Rattus norvegicus]

Related Sequences to LMP012632 proteins

Reference Database Accession Length Protein Name
GI:59709464 GenBank AAH89805.1 722 Phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Rattus norvegicus]
GI:59709464 GenBank EDL90737.1 722 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2, isoform CRA_a [Rattus norvegicus]
GI:59709464 RefSeq XP_008769318.1 722 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [Rattus norvegicus]