Gene/Proteome Database (LMPD)

LMPD ID
LMP012637
Gene ID
50555
Species
Rattus norvegicus (Rat)
Gene Name
UDP glycosyltransferase 8
Gene Symbol
Ugt8
Synonyms
Ugt8a;
Alternate Names
2-hydroxyacylsphingosine 1-beta-galactosyltransferase; cerebroside synthase; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-glucuronosyltransferase 8; ceramide UDP-galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8;
Chromosome
2
Map Location
2q42
EC Number
2.4.1.45
Summary
catalyzes the synthesis of galactocerebroside (Galc); important for the development and maintainance of the myelin membranes of the nervous system [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ugt8

Proteins

2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor
Refseq ID NP_062149
Protein GI 9507235
UniProt ID Q09426
mRNA ID NM_019276
Length 541
MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEGRDIDPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYVTKFIYRKVKSLCSRSTHSTVNGHYQNGILNGRYKGNGHIKHEKKVK
sig_peptide: 1..20 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q09426.1) calculated_mol_wt: 2306 peptide sequence: MKSYTPYFMLLWSAVGIARA mat_peptide: 21..541 product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q09426.1) calculated_mol_wt: 58839 peptide sequence: AKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLSEGRDIDPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYVTKFIYRKVKSLCSRSTHSTVNGHYQNGILNGRYKGNGHIKHEKKVK

Gene Information

Entrez Gene ID
50555
Gene Name
UDP glycosyltransferase 8
Gene Symbol
Ugt8
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003851 IEA:UniProtKB-EC F 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
GO:0008489 IMP:RGD F UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
GO:0008088 IEA:Ensembl P axon cargo transport
GO:0007010 IEA:Ensembl P cytoskeleton organization
GO:0006682 IEA:UniProtKB-UniPathway P galactosylceramide biosynthetic process
GO:0006688 TAS:RGD P glycosphingolipid biosynthetic process
GO:0042552 TAS:RGD P myelination
GO:0048812 IEA:Ensembl P neuron projection morphogenesis
GO:0030913 IEA:Ensembl P paranodal junction assembly
GO:0002175 IEA:Ensembl P protein localization to paranode region of axon

KEGG Pathway Links

KEGG Pathway ID Description
M00067 Cerebroside and sulfatide biosynthesis
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP glycosyltransferase 8
Protein Entry
CGT_RAT
UniProt ID
Q09426
Species
Rat

Comments

Comment Type Description
Catalytic Activity UDP-alpha-D-galactose + 2-(2- hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2- hydroxyacyl)sphingosine.
Function Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
Pathway Sphingolipid metabolism; galactosylceramide biosynthesis.
Similarity Belongs to the UDP-glycosyltransferase family
Subcellular Location Membrane ; Single-pass membrane protein .
Tissue Specificity Brain, restricted to the oligodendrocyte- containing cell layers of cerebrum and cerebellum.

Identical and Related Proteins

Unique RefSeq proteins for LMP012637 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9507235 RefSeq NP_062149 541 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor

Identical Sequences to LMP012637 proteins

Reference Database Accession Length Protein Name
GI:9507235 GenBank AAA16108.1 541 ceramide UDP-galactosyltransferase [Rattus norvegicus]
GI:9507235 GenBank AAA50212.1 541 UDP-galactose:ceramide galactosyltransferase [Rattus norvegicus]
GI:9507235 GenBank EDL82139.1 541 UDP galactosyltransferase 8, isoform CRA_a [Rattus norvegicus]
GI:9507235 SwissProt Q09426.1 541 RecName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase; AltName: Full=Ceramide UDP-galactosyltransferase; AltName: Full=Cerebroside synthase; AltName: Full=UDP-galactose-ceramide galactosyltransferase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012637 proteins

Reference Database Accession Length Protein Name
GI:9507235 GenBank AAA50212.1 541 UDP-galactose:ceramide galactosyltransferase [Rattus norvegicus]
GI:9507235 GenBank EDL82139.1 541 UDP galactosyltransferase 8, isoform CRA_a [Rattus norvegicus]
GI:9507235 SwissProt Q09426.1 541 RecName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase; AltName: Full=Ceramide UDP-galactosyltransferase; AltName: Full=Cerebroside synthase; AltName: Full=UDP-galactose-ceramide galactosyltransferase; Flags: Precursor [Rattus norvegicus]