Gene/Proteome Database (LMPD)

LMPD ID
LMP012639
Gene ID
50559
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA thioesterase 1
Gene Symbol
Acot1
Synonyms
Cte1;
Alternate Names
acyl-coenzyme A thioesterase 1; ACH2; CTE-I; LACH2; long chain acyl-CoA hydrolase; acyl-CoA thioesterase 1 cytosolic; cytosolic acyl-CoA thioesterase 1; acyl-CoA thioesterase 1, cytosolic; long chain acyl-CoA thioester hydrolase; inducible cytosolic acyl-coenzyme A thioester hydrolase;
Chromosome
6
Map Location
6q31
EC Number
3.1.2.2
Summary
mouse homolog has acyl-CoA thioesterase activity against long-chain acyl-CoAs; may play a role in lipid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acot1

Proteins

acyl-coenzyme A thioesterase 1
Refseq ID NP_112605
Protein GI 13786132
UniProt ID O88267
mRNA ID NM_031315
Length 419
MEATLSLGPAGRSCWDEPLSITVRGLVPEQPVTLRAALRDEKGALFRARALYRADAHGELDLARAPALGGSFTGLEPMGLLWAMEPERPFWRLVKRDVQTPFVVELEVLDGHKPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPEPGPFPGIINLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKTMETMRIEYFEEAVNYLRGHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTICYKDETIPPVTILRNQVKMTKDGLKDVVDALQSPLVEQKSFIPVERSDTTFLFLVGQDDHNWKSEFYANEISKRLQAHGKEKPQIICYPEAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHSVAQLDAWQQLQTFFHKQLGGKSHGVSPKI

Gene Information

Entrez Gene ID
50559
Gene Name
acyl-CoA thioesterase 1
Gene Symbol
Acot1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0047617 IDA:RGD F acyl-CoA hydrolase activity
GO:0052689 IEA:UniProtKB-KW F carboxylic ester hydrolase activity
GO:0016290 IEA:UniProtKB-EC F palmitoyl-CoA hydrolase activity
GO:0006637 IEA:InterPro P acyl-CoA metabolic process
GO:0006629 TAS:RGD P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko00062 Fatty acid elongation
rno00062 Fatty acid elongation
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
IPR016662 Acyl-CoA thioesterase, long chain
IPR029058 Alpha/Beta hydrolase fold
IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal

UniProt Annotations

Entry Information

Gene Name
acyl-CoA thioesterase 1
Protein Entry
ACOT1_RAT
UniProt ID
O88267
Species
Rat

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + H(2)O = CoA + palmitate.
Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16.
Induction In the liver, by peroxisome proliferator (Clofibrate) treatment, via the peroxisome proliferator-activated receptors (PPARs) or fasting for 24 hours.
Similarity Belongs to the C/M/P thioester hydrolase family
Subcellular Location Cytoplasm.
Subunit Monomer.
Tissue Specificity Expressed in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012639 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13786132 RefSeq NP_112605 419 acyl-coenzyme A thioesterase 1

Identical Sequences to LMP012639 proteins

Reference Database Accession Length Protein Name
GI:13786132 EMBL CAA70514.1 419 liver cytosolic long-chain acyl-CoA thioesterase [Rattus norvegicus]

Related Sequences to LMP012639 proteins

Reference Database Accession Length Protein Name
GI:13786132 EMBL CAA70514.1 419 liver cytosolic long-chain acyl-CoA thioesterase [Rattus norvegicus]
GI:13786132 GenBank EDL81469.1 419 rCG20735, isoform CRA_a [Rattus norvegicus]
GI:13786132 SwissProt O88267.1 419 RecName: Full=Acyl-coenzyme A thioesterase 1; Short=Acyl-CoA thioesterase 1; AltName: Full=CTE-I; AltName: Full=Inducible cytosolic acyl-coenzyme A thioester hydrolase; AltName: Full=LACH2; Short=ACH2; AltName: Full=Long chain acyl-CoA thioester hydrolase; Short=Long chain acyl-CoA hydrolase [Rattus norvegicus]