Gene/Proteome Database (LMPD)

LMPD ID
LMP012640
Gene ID
50560
Species
Rattus norvegicus (Rat)
Gene Name
inositol hexakisphosphate kinase 1
Gene Symbol
Ip6k1
Synonyms
Ihpk1; Itpk6;
Alternate Names
inositol hexakisphosphate kinase 1; insP6 kinase 1; inositol hexaphosphate kinase 1; inositol hexakisphosphate kinase 6;
Chromosome
8
Map Location
8q32
EC Number
2.7.4.21
Summary
mouse homolog catalyzes the phosphorylation of inositol hexaphosphate; may play a role in phosphoinositide-mediated signaling [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ip6k1

Proteins

inositol hexakisphosphate kinase 1
Refseq ID NP_445768
Protein GI 25742635
UniProt ID Q9ESM0
mRNA ID NM_053316
Length 433
MCVCQTMEVGQYGKNASRAGDRGVLLEPFIHQVGGHSSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVSVCFEGDSDGYINLVAYPYVESETVEQDDTPEREQPRRKHSRRSLHRSGSGSDHKEEKASLSFETSESSQETKSPKVELHSHSDVPFQMLDSNSGLSSEKISYNPWSLRCHKQQLSRMRSESKDRKLYKFLLLENVVHHFKYPCVLDLKMGTRQHGDDASAEKAARQMRKCEQSTSASLGVRVCGMQVYQLDTGHYLCRNKYYGRGLSIEGFRNALYQYLHNGLDLRRDLFEPILSKLRGLKAVLERQASYRFYSSSLLVIYDGKECRSELRLKHVDMGLPEVPPLCGPSTSPSNTSLEAGPSSPPKVDVRMIDFAHSTFKGFRDDPTVHDGPDRGYVFGLENLISIMEQMRDENQ

Gene Information

Entrez Gene ID
50560
Gene Name
inositol hexakisphosphate kinase 1
Gene Symbol
Ip6k1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005730 IEA:Ensembl C nucleolus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0046854 ISS:UniProtKB P phosphatidylinositol phosphorylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954517 Synthesis of IPs in the nucleus
5954518 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol hexakisphosphate kinase 1
Protein Entry
IP6K1_RAT
UniProt ID
Q9ESM0
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity)
Similarity Belongs to the inositol phosphokinase (IPK) family
Subcellular Location Cytoplasm . Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP012640 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25742635 RefSeq NP_445768 433 inositol hexakisphosphate kinase 1

Identical Sequences to LMP012640 proteins

Reference Database Accession Length Protein Name
GI:25742635 GenBank AAH78702.1 433 Inositol hexakisphosphate kinase 1 [Rattus norvegicus]
GI:25742635 GenBank EDL77199.1 433 inositol hexaphosphate kinase 1 [Rattus norvegicus]
GI:25742635 RefSeq XP_006243901.1 433 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Rattus norvegicus]
GI:25742635 SwissProt Q9ESM0.1 433 RecName: Full=Inositol hexakisphosphate kinase 1; Short=InsP6 kinase 1; AltName: Full=Inositol hexaphosphate kinase 1 [Rattus norvegicus]

Related Sequences to LMP012640 proteins

Reference Database Accession Length Protein Name
GI:25742635 DBBJ BAB13737.1 433 inositol hexakisphosphate kinase [Rattus norvegicus]
GI:25742635 GenBank AAH78702.1 433 Inositol hexakisphosphate kinase 1 [Rattus norvegicus]
GI:25742635 SwissProt Q9ESM0.1 433 RecName: Full=Inositol hexakisphosphate kinase 1; Short=InsP6 kinase 1; AltName: Full=Inositol hexaphosphate kinase 1 [Rattus norvegicus]