Gene/Proteome Database (LMPD)

LMPD ID
LMP012643
Gene ID
50681
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA oxidase 1, palmitoyl
Gene Symbol
Acox1
Synonyms
RATACOA1;
Alternate Names
peroxisomal acyl-coenzyme A oxidase 1; AOX; palmitoyl-CoA oxidase; acyl-Coenzyme A oxidase 1, palmitoyl;
Chromosome
10
Map Location
10q32.3
EC Number
1.3.3.6
Summary
catalyzes the oxidation of fatty acyl CoA to trans-2-enoyl-CoA and peroxide [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acox1

Proteins

peroxisomal acyl-coenzyme A oxidase 1
Refseq ID NP_059036
Protein GI 8394149
UniProt ID P07872
mRNA ID NM_017340
Length 661
MNPDLRKERASATFNPELITHILDGSPENTRRRREIENLILNDPDFQHEDYNFLTRSQRYEVAVKKSATMVKKMREYGISDPEEIMWFKKLYLANFVEPVGLNYSMFIPTLLNQGTTAQQEKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACTIAIRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVRSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTMVDINSLEGLTEAYKLRAARLVEIAAKNLQTHVSHRKSKEVAWNLTSVDLVRASEAHCHYVVVKVFSDKLPKIQDKAVQAVLRNLCLLYSLYGISQKGGDFLEGSIITGAQLSQVNARILELLTLIRPNAVALVDAFDFKDMTLGSVLGRYDGNVYENLFEWAKKSPLNKTEVHESYHKHLKPLQSKL

Gene Information

Entrez Gene ID
50681
Gene Name
acyl-CoA oxidase 1, palmitoyl
Gene Symbol
Acox1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005778 IEA:Ensembl C peroxisomal membrane
GO:0005777 ISS:UniProtKB C peroxisome
GO:0071949 IEA:Ensembl F FAD binding
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0003997 ISS:UniProtKB F acyl-CoA oxidase activity
GO:0005504 IDA:RGD F fatty acid binding
GO:0016401 IDA:RGD F palmitoyl-CoA oxidase activity
GO:0033540 IDA:RGD P fatty acid beta-oxidation using acyl-CoA oxidase
GO:0019395 ISS:UniProtKB P fatty acid oxidation
GO:0006091 ISS:UniProtKB P generation of precursor metabolites and energy
GO:0055088 IEA:Ensembl P lipid homeostasis
GO:0006629 ISS:UniProtKB P lipid metabolic process
GO:0016559 IEA:Ensembl P peroxisome fission
GO:2000189 IEA:Ensembl P positive regulation of cholesterol homeostasis
GO:0006693 ISS:UniProtKB P prostaglandin metabolic process
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0000038 IEA:Ensembl P very long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko04146 Peroxisome
rno04146 Peroxisome
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism
M00087 beta-Oxidation
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954188 Beta-oxidation of very long chain fatty acids
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954333 PPARA activates gene expression
5953470 Peroxisomal lipid metabolism
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954542 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5954543 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR012258 Acyl-CoA oxidase
IPR002655 Acyl-CoA oxidase, C-terminal
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR029320 Acyl-coenzyme A oxidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
acyl-CoA oxidase 1, palmitoyl
Protein Entry
ACOX1_RAT
UniProt ID
P07872
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ACO-I; IsoId=P07872-1; Sequence=Displayed; Name=2; Synonyms=ACO-II; IsoId=P07872-2; Sequence=VSP_000147;
Catalytic Activity Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 1 shows optimum activity with a chain length of 10 carbons while isoform 2 exhibits optimum activity with 14 carbons
Pathway Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Similarity Belongs to the acyl-CoA oxidase family
Subcellular Location Peroxisome.
Subunit Homodimer. The enzyme contains three components A, B and C, the latter two being produced from the first by a proteolytic cleavage. {ECO:0000269|PubMed:11872165, ECO:0000269|PubMed:16672280}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012643 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8394149 RefSeq NP_059036 661 peroxisomal acyl-coenzyme A oxidase 1

Identical Sequences to LMP012643 proteins

Reference Database Accession Length Protein Name
GI:8394149 EMBL CBU95978.1 661 unnamed protein product [Rattus norvegicus]
GI:8394149 GenBank AGX52655.1 661 Sequence 5665 from patent US 8541208
GI:8394149 GenBank AGX57592.1 661 Sequence 15527 from patent US 8541208
GI:8394149 GenBank AGX63376.1 661 Sequence 26856 from patent US 8541208

Related Sequences to LMP012643 proteins

Reference Database Accession Length Protein Name
GI:8394149 EMBL CBU85781.1 661 unnamed protein product [Rattus norvegicus]
GI:8394149 EMBL CBU90562.1 661 unnamed protein product [Rattus norvegicus]
GI:8394149 EMBL CBU95978.1 661 unnamed protein product [Rattus norvegicus]