Gene/Proteome Database (LMPD)

LMPD ID
LMP012647
Gene ID
54248
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase, beta
Gene Symbol
Dgkb
Synonyms
Dagk;
Alternate Names
diacylglycerol kinase beta; DGK-beta; DAG kinase beta; diglyceride kinase beta; Diacylglycerol kinase 90kDa; 90 kDa diacylglycerol kinase; diacylglycerol kinase beta, 90kDa;
Chromosome
6
Map Location
6q21
EC Number
2.7.1.107
Summary
beta isotype of the diacylglycerol kinase family, regulates intracellular concentrations of the second messenger diacylglycerol (DAG) [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dgkb

Proteins

diacylglycerol kinase beta
Refseq ID NP_062177
Protein GI 9506535
UniProt ID P49621
mRNA ID NM_019304
Length 801
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPRSSPANTCFPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTMPTAGTSVPEERQSTAKKEKGSSQQPNKVTDKNKMQRANSVTMDGQGLQITPIPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLQGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTRNRSKE

Gene Information

Entrez Gene ID
54248
Gene Name
diacylglycerol kinase, beta
Gene Symbol
Dgkb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IDA:RGD C membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004143 IDA:RGD F diacylglycerol kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR029477 Diacylglycerol kinase type I, N-terminal
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, beta
Protein Entry
DGKB_RAT
UniProt ID
P49621
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Stimulated by phosphatidylserine.
Function Exhibits high phosphorylation activity for long-chain diacylglycerols.
Similarity Belongs to the eukaryotic diacylglycerol kinase family
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers
Subcellular Location Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.
Tissue Specificity Confined to restricted neuronal populations such as the caudate-putamen, the accumbens nucleus, and the olfactory tubercle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012647 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9506535 RefSeq NP_062177 801 diacylglycerol kinase beta

Identical Sequences to LMP012647 proteins

Reference Database Accession Length Protein Name
GI:9506535 DBBJ BAA03675.1 801 90kDa-diacylglycerol kinase [Rattus norvegicus]
GI:9506535 GenBank AAQ52207.1 801 Sequence 7 from patent US 6593121
GI:9506535 SwissProt P49621.1 801 RecName: Full=Diacylglycerol kinase beta; Short=DAG kinase beta; AltName: Full=90 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase beta; Short=DGK-beta [Rattus norvegicus]

Related Sequences to LMP012647 proteins

Reference Database Accession Length Protein Name
GI:9506535 DBBJ BAA03675.1 801 90kDa-diacylglycerol kinase [Rattus norvegicus]
GI:9506535 GenBank AAQ52207.1 801 Sequence 7 from patent US 6593121
GI:9506535 SwissProt P49621.1 801 RecName: Full=Diacylglycerol kinase beta; Short=DAG kinase beta; AltName: Full=90 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase beta; Short=DGK-beta [Rattus norvegicus]