Gene/Proteome Database (LMPD)

LMPD ID
LMP012649
Gene ID
54260
Species
Rattus norvegicus (Rat)
Gene Name
inositol-trisphosphate 3-kinase B
Gene Symbol
Itpkb
Alternate Names
inositol-trisphosphate 3-kinase B; IP3K B; IP3K-B; IP3 3-kinase B; insP 3-kinase B; inositol 1,4,5-trisphosphate 3-kinase B;
Chromosome
13
Map Location
13q26
EC Number
2.7.1.127
Summary
regulates inositol phosphate metabolism which is required in cell signaling [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Itpkb

Proteins

inositol-trisphosphate 3-kinase B
Refseq ID NP_062185
Protein GI 164565364
UniProt ID P42335
mRNA ID NM_019312
Length 934
MAVYCYALNSLVIMNSTNELKSGSPLPSGSETPQPSGRAALSPGSVFSPGRGASFLFPPAESLSLEEPGSAGGWRSGRRRLNSSSGSGGGSSSSNSSSSSGVGSPSWAGRLRGDAQQVVATRILSPPGPEEAQRKLRILQRELQNVQVNQKVGMFEAQIQAQTSAIQAPRSPRLGRARSPSPCPFRSSSQPPERVLAPCSPSEERRTKSWGEQCTETPDANSRRRSRLSTHPSKDKEGVAPLLGPASPTRLGTQSPSTSVRMERGSPASPRCGSPTPMEIDKRTAPSLEHFGTSLTLATKVAASAASAGPHPGHDSVLMEADCELGAMRPWEAHLERRGQFLGRETGSAPEPIRTHIREPPGRVERVHSVGGQGSWTPEVIKRPEEGTVDAQSSELSENPRWSRLPGDPGSVGPEKGGSRIPGIRGPQQTLDSMREGSSALGLLGGSQAAQPGSMDVETGISCGRMLEPLPPGEVTTNLKEPQCLPGDRMGMQPESSIVWPSAVEEAPLIWTCDTGIQLKGTWRSQDGDAHPSCQEKSPDQKDKACSPSNIPAIPAVIITDMGAQEDGGLEEIQGSPRGPLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVQWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMADVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMVEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGSVNRDFKKTKTREQVTEAFREFTKGNQNILIAYRDRLKAIRETLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLIDILTEMSQGSPLT

Gene Information

Entrez Gene ID
54260
Gene Name
inositol-trisphosphate 3-kinase B
Gene Symbol
Itpkb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008440 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 3-kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954514 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol-trisphosphate 3-kinase B
Protein Entry
IP3KB_RAT
UniProt ID
P42335
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme Regulation IP3K is activated by calmodulin.
Sequence Caution Sequence=CAA52298.1; Type=Frameshift; Positions=175; Evidence= ;
Similarity Belongs to the inositol phosphokinase (IPK) family
Subunit Interacts with DMTN

Identical and Related Proteins

Unique RefSeq proteins for LMP012649 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
164565364 RefSeq NP_062185 934 inositol-trisphosphate 3-kinase B

Identical Sequences to LMP012649 proteins

Reference Database Accession Length Protein Name
GI:164565364 EMBL CAC40660.1 934 inositol 1,4,5-trisphosphate 3-kinase, isoform B [Rattus norvegicus]
GI:164565364 GenBank EDL94824.1 934 inositol 1,4,5-trisphosphate 3-kinase B [Rattus norvegicus]
GI:164565364 SwissProt P42335.3 934 RecName: Full=Inositol-trisphosphate 3-kinase B; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase B; Short=IP3 3-kinase B; Short=IP3K B; Short=InsP 3-kinase B [Rattus norvegicus]

Related Sequences to LMP012649 proteins

Reference Database Accession Length Protein Name
GI:164565364 EMBL CAC40660.1 934 inositol 1,4,5-trisphosphate 3-kinase, isoform B [Rattus norvegicus]
GI:164565364 GenBank EDL94824.1 934 inositol 1,4,5-trisphosphate 3-kinase B [Rattus norvegicus]
GI:164565364 SwissProt P42335.3 934 RecName: Full=Inositol-trisphosphate 3-kinase B; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase B; Short=IP3 3-kinase B; Short=IP3K B; Short=InsP 3-kinase B [Rattus norvegicus]