Gene/Proteome Database (LMPD)

LMPD ID
LMP012650
Gene ID
54299
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor co-repressor 1
Gene Symbol
Ncor1
Synonyms
Rxrip13;
Alternate Names
nuclear receptor corepressor 1; NCoR; N-CoR; N-CoR1; N-Cor/SMRT corepressor Rip13; N-Cor/SMRT corepressor, Rip13;
Chromosome
10
Map Location
10q24
Summary
expressed in skeletal muscle [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ncor1

Proteins

nuclear receptor corepressor 1
Refseq ID NP_001258032
Protein GI 402744284
mRNA ID NM_001271103
Length 2414
MSSSGYPPNQGAFSTEQSRYPSQSVQYTFPSTRHQQEFAVPDYRSSHIEVSQASQLLQQQQQQQQLRRRPSLLSEFHPGSDRPQERRTGYEQFHSGPSPVDHDSLESKRPRLEPVSDAHFQRVSAAVLPLVHTLPEGLRASADAKKDSAFGGKHEAPSSPLAGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKMEKKEEEKKDDEEKDEKEESKETTKEKDRTEATAEETEEREQVTPRGRKTANSQGRRKGRITRSMTSEAAAASAAAAATEEPPPPLPPPPEPVSTEPVETSRWTEEEMEVAKKGNIQQCIIYNSASRKPREERDVSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAAKSSEDSSENAASRGNTEPVAELEATTDPAPCASPSSAVPTTKPAESESVEAQVTDSASVETAEPMDVDHEECGAQGSSVLDPPAPTKADSVDPEIQVPENTASKGEGDAKDRDLESASEKTEARDEDLVVAEQMQRPEPQSDNDSSATCSADEDVDGEPERQRVFPMDAKPSLLNPPGSILISSPIKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPSFIMGGSISQGTPGTYLTSHSQAYTPEAAKPSVGSISLGLPRQQESTKSAPLTYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAVQEGSITRGTPASKISVESISSLRGSITQGTPALPQAGIPTEALVKGPVSRMPIEESSPEKVREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEMSLKRSYESVEGNVKQGMSMRESPVSAAPLEERTVLSGSIMQGTPRATAESFEDGLKYPKQIKRESPPSRAFEGAITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIKHNVKSLITGPSKLPRGMLEIVPENIKVVERGKYEDVKAGEPVRPRHTSVVSSGPSVLRSTLHEAPKAQLSPGIYDDSSARRTPVSYQNTISRGSPMMNRTSDGSSSKTTSHERKSALTPTQRESVPAKSPVPAVDSVVSHSPFDPHHRSTTAGEVYRSHLPTHLDPAMPFHRALDPAAAYLFQRQLSPTPGYPSQYQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHAGGTSTPPMDRITYIPGTQITFPPRPYNAASLSPGHPTHLAAAASAEREREREREKERERERERERERERERERERERERERERITAAPTDLYLRPGSEQPGRPGSHGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPSGGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLEDNVRSRSAAVSEQQQLEQKNLEVEKRSVQCVCTSSALPSGKPQPHASVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSSLSSHRYEAPSDAIEVISPASSPAPPQEKPQAYQPEMVKANQAENESPQQYEGPLHHYRSQQGSPSPQQQPPLPPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVPSQPSTSTFQTSPSALSSTPVRTKPSSRYSPESQSQTVLHPRPGPRVSPENLVDKSRGSRPGKSPERSHIPSEPYEPISPPQGPAVHEKQDSMLLLSQRGMDPAEQRSDSRSPGSISYLPSFFTKLESTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGAVSSRSHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMPHPVGVVPGSASTSVVTSSETRRDEGDPSPHSGVCKPKLINKSNSRKSKSPIPGQNYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTIRMLSSTPPTPIACAPSAITQAAPHQQSRIWEREPAPLLSAQYETLSDSDD

Gene Information

Entrez Gene ID
54299
Gene Name
nuclear receptor co-repressor 1
Gene Symbol
Ncor1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005634 IDA:RGD C nucleus
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0001012 IDA:RGD F RNA polymerase II regulatory region DNA binding
GO:0003682 IDA:RGD F chromatin binding
GO:0030331 IPI:RGD F estrogen receptor binding
GO:0042975 IPI:RGD F peroxisome proliferator activated receptor binding
GO:0019904 IPI:RGD F protein domain specific binding
GO:0042974 IPI:RGD F retinoic acid receptor binding
GO:0046965 IPI:RGD F retinoid X receptor binding
GO:0021549 IEP:RGD P cerebellum development
GO:0016568 IEA:UniProtKB-KW P chromatin modification
GO:0007595 IEP:RGD P lactation
GO:0010629 IMP:RGD P negative regulation of gene expression
GO:0045892 IMP:RGD P negative regulation of transcription, DNA-templated
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0007519 IEP:RGD P skeletal muscle tissue development
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
rno04919 Thyroid hormone signaling pathway
ko05202 Transcriptional misregulation in cancer
rno05202 Transcriptional misregulation in cancer

Domain Information

InterPro Annotations

Accession Description

UniProt Annotations

Entry Information

Gene Name
nuclear receptor co-repressor 1
Species
Rat

Comments

Comment Type Description
Domain The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity). {ECO:0000250}.
Domain The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3). {ECO:0000250}.
Function Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6 (By similarity). {ECO:0000250}.
Ptm Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000250}.
Similarity Belongs to the N-CoR nuclear receptor corepressors family. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000250}.
Subunit Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid receptor (TR) and the retinoid acid receptor (RAR) in the absence of ligand. Interacts directly with RARA; the interaction is facilitated with RARA trimethylation. Component of the N-Cor repressor complex, at least composed of CBFA2T3, HEXIM1, NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with ZBTB33; the interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with TRIM28 and KDM3A. Interacts (via the RD1 domain) with BAZ1A (via its N-terminal); the interaction corepresses a number of NCOR1-regulated genes. Interacts with BCL6, C1D, DACH1, HEXIM1, HDAC7, RORA, RORC, SAP30, SIAH2, SIN3A and SIN3B. May interact with DEAF1. Interacts with RXRA (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012650 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
402744284 RefSeq NP_001258032 2414 nuclear receptor corepressor 1

Identical Sequences to LMP012650 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012650 proteins

Reference Database Accession Length Protein Name
GI:402744284 GenBank EDL10341.1 2454 nuclear receptor co-repressor 1, isoform CRA_a [Mus musculus]
GI:402744284 GenBank EDM04703.1 2467 nuclear receptor co-repressor 1, isoform CRA_a [Rattus norvegicus]
GI:402744284 RefSeq NP_001239242.1 2454 nuclear receptor corepressor 1 isoform 1 [Mus musculus]