Gene/Proteome Database (LMPD)

LMPD ID
LMP012651
Gene ID
54398
Species
Rattus norvegicus (Rat)
Gene Name
palmitoyl-protein thioesterase 2
Gene Symbol
Ppt2
Alternate Names
lysosomal thioesterase PPT2;
Chromosome
20
Map Location
20p12
EC Number
3.1.2.-
Summary
human homolog catalyzes the removal of long chain fatty acyl groups from modified cysteine residues [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ppt2

Proteins

lysosomal thioesterase PPT2 precursor
Refseq ID NP_062240
Protein GI 9506987
UniProt ID O70489
mRNA ID NM_019367
Length 302
MPGLWRQRLPSAWALLLLPFLPLLLPAAPAPHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDEHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGVSHTTWHSNRTLYDACIEPWLS
sig_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (O70489.1) calculated_mol_wt: 3084 peptide sequence: MPGLWRQRLPSAWALLLLPFLPLLLPA mat_peptide: 28..302 product: Lysosomal thioesterase PPT2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O70489.1) calculated_mol_wt: 31290 peptide sequence: APAPHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHPGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDEHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRICYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGVSHTTWHSNRTLYDACIEPWLS

Gene Information

Entrez Gene ID
54398
Gene Name
palmitoyl-protein thioesterase 2
Gene Symbol
Ppt2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IBA:RefGenome C lysosome
GO:0008474 IEA:Ensembl F palmitoyl-(protein) hydrolase activity
GO:0016790 IBA:RefGenome F thiolester hydrolase activity
GO:0006464 IEA:InterPro P cellular protein modification process

KEGG Pathway Links

KEGG Pathway ID Description
ko00062 Fatty acid elongation
rno00062 Fatty acid elongation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko04142 Lysosome
rno04142 Lysosome
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002472 Palmitoyl protein thioesterase

UniProt Annotations

Entry Information

Gene Name
palmitoyl-protein thioesterase 2
Protein Entry
PPT2_RAT
UniProt ID
O70489
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70489-1; Sequence=Displayed; Name=2; Synonyms=Truncated; IsoId=O70489-2; Sequence=VSP_005189, VSP_005190;
Catalytic Activity Palmitoyl-protein + H(2)O = palmitate + protein.
Function Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity)
Similarity Belongs to the palmitoyl-protein thioesterase family
Subcellular Location Lysosome .

Identical and Related Proteins

Unique RefSeq proteins for LMP012651 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9506987 RefSeq NP_062240 302 lysosomal thioesterase PPT2 precursor

Identical Sequences to LMP012651 proteins

Reference Database Accession Length Protein Name
GI:9506987 RefSeq XP_006256082.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]
GI:9506987 RefSeq XP_006256084.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]
GI:9506987 RefSeq XP_006256085.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]
GI:9506987 RefSeq XP_008770984.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012651 proteins

Reference Database Accession Length Protein Name
GI:9506987 RefSeq XP_006256080.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]
GI:9506987 RefSeq XP_006256081.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]
GI:9506987 RefSeq XP_006256082.1 302 PREDICTED: lysosomal thioesterase PPT2 isoform X1 [Rattus norvegicus]