Gene/Proteome Database (LMPD)

LMPD ID
LMP012655
Gene ID
56611
Species
Rattus norvegicus (Rat)
Gene Name
annexin A2
Gene Symbol
Anxa2
Synonyms
ANX2;
Alternate Names
annexin A2; p36; PAP-IV; annexin-2; protein I; lipocortin II; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; placental anticoagulant protein IV;
Chromosome
8
Map Location
8q24
Summary
a plasminogen receptor; may be involved in cellular transformation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Anxa2

Proteins

annexin A2
Refseq ID NP_063970
Protein GI 9845234
UniProt ID Q07936
mRNA ID NM_019905
Length 339
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD

Gene Information

Entrez Gene ID
56611
Gene Name
annexin A2
Gene Symbol
Anxa2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0005604 IEA:UniProtKB-KW C basement membrane
GO:0005938 IDA:RGD C cell cortex
GO:0009986 IEA:Ensembl C cell surface
GO:0005737 IDA:RGD C cytoplasm
GO:0005769 IEA:Ensembl C early endosome
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0019897 IEA:Ensembl C extrinsic component of plasma membrane
GO:0031902 IEA:Ensembl C late endosome membrane
GO:0005811 IEA:Ensembl C lipid particle
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0044354 IDA:RGD C macropinosome
GO:0045121 IEA:Ensembl C membrane raft
GO:0030496 IEA:Ensembl C midbody
GO:0035749 IEA:Ensembl C myelin sheath adaxonal region
GO:0005634 IEA:Ensembl C nucleus
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0005886 IDA:RGD C plasma membrane
GO:0043234 IDA:RGD C protein complex
GO:0001726 IDA:RGD C ruffle
GO:0042383 IEA:Ensembl C sarcolemma
GO:0031982 IDA:RGD C vesicle
GO:0017137 IPI:RGD F Rab GTPase binding
GO:0051015 TAS:RGD F actin filament binding
GO:0005509 TAS:RGD F calcium ion binding
GO:0005544 IEA:UniProtKB-KW F calcium-dependent phospholipid binding
GO:0005546 IDA:RGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0019834 IEA:Ensembl F phospholipase A2 inhibitor activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0001525 IEA:Ensembl P angiogenesis
GO:0007589 IMP:RGD P body fluid secretion
GO:0071229 IEA:Ensembl P cellular response to acid chemical
GO:0030199 IEA:Ensembl P collagen fibril organization
GO:0042730 IEA:Ensembl P fibrinolysis
GO:0006900 IEA:Ensembl P membrane budding
GO:0001765 IEA:Ensembl P membrane raft assembly
GO:0036035 IEA:Ensembl P osteoclast development
GO:0051099 IEA:Ensembl P positive regulation of binding
GO:0048146 IMP:RGD P positive regulation of fibroblast proliferation
GO:0001934 IMP:RGD P positive regulation of protein phosphorylation
GO:0031340 IEA:Ensembl P positive regulation of vesicle fusion
GO:0051290 IEA:Ensembl P protein heterotetramerization
GO:0072661 IMP:RGD P protein targeting to plasma membrane
GO:0051917 TAS:RGD P regulation of fibrinolysis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953715 Dissolution of Fibrin Clot
5953645 Hemostasis

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018252 Annexin repeat, conserved site
IPR002389 Annexin, type II
IPR018502 Annexin_repeat

UniProt Annotations

Entry Information

Gene Name
annexin A2
Protein Entry
ANXA2_RAT
UniProt ID
Q07936
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Short; IsoId=Q07936-1; Sequence=Displayed; Name=Long; IsoId=Q07936-2; Sequence=VSP_000287;
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Miscellaneous It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Ptm ISGylated
Similarity Belongs to the annexin family
Similarity Contains 4 annexin repeats
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . Note=In the lamina beneath the plasma membrane.
Subunit Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with COCH (By similarity)
Web Resource Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";

Identical and Related Proteins

Unique RefSeq proteins for LMP012655 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9845234 RefSeq NP_063970 339 annexin A2

Identical Sequences to LMP012655 proteins

Reference Database Accession Length Protein Name
GI:9845234 GenBank AAH59136.1 339 Annexin A2 [Rattus norvegicus]
GI:9845234 GenBank EDL84210.1 339 annexin A2, isoform CRA_a [Rattus norvegicus]
GI:9845234 GenBank EDL84211.1 339 annexin A2, isoform CRA_a [Rattus norvegicus]
GI:9845234 SwissProt Q07936.2 339 RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36 [Rattus norvegicus]

Related Sequences to LMP012655 proteins

Reference Database Accession Length Protein Name
GI:9845234 EMBL CAA47343.1 339 calpactin I heavy chain [Rattus norvegicus]
GI:9845234 GenBank AAH59136.1 339 Annexin A2 [Rattus norvegicus]
GI:9845234 SwissProt Q07936.2 339 RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36 [Rattus norvegicus]