Gene/Proteome Database (LMPD)

LMPD ID
LMP012655
Gene ID
56611
Species
Rattus norvegicus (Rat)
Gene Name
annexin A2
Gene Symbol
Anxa2
Synonyms
ANX2;
Alternate Names
annexin A2; p36; PAP-IV; annexin-2; protein I; lipocortin II; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; placental anticoagulant protein IV;
Chromosome
8
Map Location
8q24
Summary
a plasminogen receptor; may be involved in cellular transformation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Anxa2

Proteins

annexin A2
Refseq ID NP_063970
Protein GI 9845234
UniProt ID Q07936
mRNA ID NM_019905
Length 339
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD

Gene Information

Entrez Gene ID
56611
Gene Name
annexin A2
Gene Symbol
Anxa2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005604 IEA:UniProtKB-KW C basement membrane
GO:0005938 IDA:RGD C cell cortex
GO:0009986 IEA:Ensembl C cell surface
GO:0005737 IDA:RGD C cytoplasm
GO:0005769 IEA:Ensembl C early endosome
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0019897 IEA:Ensembl C extrinsic component of plasma membrane
GO:0031902 IEA:Ensembl C late endosome membrane
GO:0005811 IEA:Ensembl C lipid particle
GO:0005765 IEA:Ensembl C lysosomal membrane
GO:0044354 IDA:RGD C macropinosome
GO:0045121 IEA:Ensembl C membrane raft
GO:0030496 IEA:Ensembl C midbody
GO:0035749 IEA:Ensembl C myelin sheath adaxonal region
GO:0005634 IEA:Ensembl C nucleus
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0005886 IDA:RGD C plasma membrane
GO:0043234 IDA:RGD C protein complex
GO:0001726 IDA:RGD C ruffle
GO:0042383 IEA:Ensembl C sarcolemma
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0031982 IDA:RGD C vesicle
GO:0051015 TAS:RGD F actin filament binding
GO:0005544 IEA:UniProtKB-KW F calcium-dependent phospholipid binding
GO:0005509 TAS:RGD F calcium ion binding
GO:0005546 IDA:RGD F phosphatidylinositol-4,5-bisphosphate binding
GO:0019834 IEA:Ensembl F phospholipase A2 inhibitor activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0017137 IPI:RGD F Rab GTPase binding
GO:0001525 IEA:Ensembl P angiogenesis
GO:0007589 IMP:RGD P body fluid secretion
GO:0071229 IEA:Ensembl P cellular response to acid chemical
GO:0030199 IEA:Ensembl P collagen fibril organization
GO:0042730 IEA:Ensembl P fibrinolysis
GO:0006900 IEA:Ensembl P membrane budding
GO:0001765 IEA:Ensembl P membrane raft assembly
GO:0036035 IEA:Ensembl P osteoclast development
GO:0051099 IEA:Ensembl P positive regulation of binding
GO:0048146 IMP:RGD P positive regulation of fibroblast proliferation
GO:0001934 IMP:RGD P positive regulation of protein phosphorylation
GO:0031340 IEA:Ensembl P positive regulation of vesicle fusion
GO:0051290 IEA:Ensembl P protein heterotetramerization
GO:0072661 IMP:RGD P protein targeting to plasma membrane
GO:0051917 TAS:RGD P regulation of fibrinolysis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953715 Dissolution of Fibrin Clot
5953645 Hemostasis

Domain Information

InterPro Annotations

Accession Description
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin repeat, conserved site
IPR002389 Annexin, type II

UniProt Annotations

Entry Information

Gene Name
annexin A2
Protein Entry
ANXA2_RAT
UniProt ID
Q07936
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Short; IsoId=Q07936-1; Sequence=Displayed; Name=Long; IsoId=Q07936-2; Sequence=VSP_000287;
Domain A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Miscellaneous It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
Ptm ISGylated
Similarity Belongs to the annexin family
Similarity Contains 4 annexin repeats
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . Note=In the lamina beneath the plasma membrane.
Subunit Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with COCH (By similarity)
Web Resource Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";

Identical and Related Proteins

Unique RefSeq proteins for LMP012655 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9845234 RefSeq NP_063970 339 annexin A2

Identical Sequences to LMP012655 proteins

Reference Database Accession Length Protein Name
GI:9845234 GenBank AAH59136.1 339 Annexin A2 [Rattus norvegicus]
GI:9845234 GenBank EDL84210.1 339 annexin A2, isoform CRA_a [Rattus norvegicus]
GI:9845234 GenBank EDL84211.1 339 annexin A2, isoform CRA_a [Rattus norvegicus]
GI:9845234 SwissProt Q07936.2 339 RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36 [Rattus norvegicus]

Related Sequences to LMP012655 proteins

Reference Database Accession Length Protein Name
GI:9845234 EMBL CAA47343.1 339 calpactin I heavy chain [Rattus norvegicus]
GI:9845234 GenBank AAH59136.1 339 Annexin A2 [Rattus norvegicus]
GI:9845234 SwissProt Q07936.2 339 RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36 [Rattus norvegicus]