Gene/Proteome Database (LMPD)

LMPD ID
LMP012664
Gene ID
58949
Species
Rattus norvegicus (Rat)
Gene Name
platelet-activating factor receptor
Gene Symbol
Ptafr
Alternate Names
platelet-activating factor receptor; PAFr; PAF-R;
Chromosome
5
Map Location
5q36
Summary
acts as a receptor to mediate the biological effects of platelet-activating factor [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ptafr

Proteins

platelet-activating factor receptor
Refseq ID NP_445773
Protein GI 16758018
UniProt ID P46002
mRNA ID NM_053321
Length 341
MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN

Gene Information

Entrez Gene ID
58949
Gene Name
platelet-activating factor receptor
Gene Symbol
Ptafr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001530 IEA:Ensembl F lipopolysaccharide binding
GO:0001875 IEA:Ensembl F lipopolysaccharide receptor activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0004992 IEA:Ensembl F platelet activating factor receptor activity
GO:0006935 IEA:UniProtKB-KW P chemotaxis
GO:0001816 IEA:Ensembl P cytokine production
GO:0006954 IEA:Ensembl P inflammatory response
GO:0032959 IEA:Ensembl P inositol trisphosphate biosynthetic process
GO:0048015 IEA:Ensembl P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
ko05150 Staphylococcus aureus infection
rno05150 Staphylococcus aureus infection

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5953536 Cytokine Signaling in Immune system
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953410 Immune System
5954352 Interferon Signaling
5954351 Interferon gamma signaling
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR002282 Platelet-activating factor receptor

UniProt Annotations

Entry Information

Gene Name
platelet-activating factor receptor
Protein Entry
PTAFR_RAT
UniProt ID
P46002
Species
Rat

Comments

Comment Type Description
Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with ARRB1
Tissue Specificity Present in almost all organs including spleen, small intestine, kidney, lung, liver and brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP012664 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758018 RefSeq NP_445773 341 platelet-activating factor receptor

Identical Sequences to LMP012664 proteins

Reference Database Accession Length Protein Name
GI:16758018 GenBank AAH72491.1 341 Platelet-activating factor receptor [Rattus norvegicus]
GI:16758018 GenBank EDL80644.1 341 platelet-activating factor receptor [Rattus norvegicus]
GI:16758018 RefSeq XP_006239125.1 341 PREDICTED: platelet-activating factor receptor isoform X1 [Rattus norvegicus]
GI:16758018 RefSeq XP_006239126.1 341 PREDICTED: platelet-activating factor receptor isoform X1 [Rattus norvegicus]

Related Sequences to LMP012664 proteins

Reference Database Accession Length Protein Name
GI:16758018 RefSeq XP_006239125.1 341 PREDICTED: platelet-activating factor receptor isoform X1 [Rattus norvegicus]
GI:16758018 RefSeq XP_006239126.1 341 PREDICTED: platelet-activating factor receptor isoform X1 [Rattus norvegicus]
GI:16758018 SwissProt P46002.1 341 RecName: Full=Platelet-activating factor receptor; Short=PAF-R; Short=PAFr [Rattus norvegicus]