Gene/Proteome Database (LMPD)
LMPD ID
LMP012667
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
Rab geranylgeranyltransferase, alpha subunit
Gene Symbol
Alternate Names
geranylgeranyl transferase type-2 subunit alpha; rab GGTase alpha; rab GG transferase alpha; Rab geranylgeranyltransferase alpha; Rab geranylgeranyl transferase, a subunit; rab geranylgeranyltransferase subunit alpha; rab geranyl-geranyltransferase subunit alpha; geranylgeranyl transferase type II subunit alpha;
Chromosome
15
Map Location
15p13
EC Number
2.5.1.60
Summary
subunit of Rab geranylgeranyl transferase, which catalyses the transfer of geranylgeranyl groups to Rab protein cysteine residues [RGD, Feb 2006]
Orthologs
Proteins
| geranylgeranyl transferase type-2 subunit alpha | |
|---|---|
| Refseq ID | NP_113842 |
| Protein GI | 13928906 |
| UniProt ID | Q08602 |
| mRNA ID | NM_031654 |
| Length | 567 |
| MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT | |
Gene Information
Entrez Gene ID
Gene Name
Rab geranylgeranyltransferase, alpha subunit
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005968 | IDA:UniProtKB | C | Rab-protein geranylgeranyltransferase complex |
| GO:0017137 | IDA:UniProtKB | F | Rab GTPase binding |
| GO:0004663 | IDA:UniProtKB | F | Rab geranylgeranyltransferase activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0018344 | IDA:UniProtKB | P | protein geranylgeranylation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
Rab geranylgeranyltransferase, alpha subunit
Protein Entry
PGTA_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. {ECO:0000269|PubMed:18756270, ECO:0000269|PubMed:19894725, ECO:0000269|PubMed:21520375, ECO:0000269|PubMed:22963166}. |
| Enzyme Regulation | The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM. |
| Function | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:18399557, ECO:0000269|PubMed:18756270, ECO:0000269|PubMed:19894725, ECO:0000269|PubMed:21520375, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:8505342}. |
| Similarity | Belongs to the protein prenyltransferase subunit alpha family |
| Similarity | Contains 5 LRR (leucine-rich) repeats |
| Similarity | Contains 6 PFTA repeats. {ECO:0000255|PROSITE- ProRule:PRU00488}. |
| Subunit | Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. {ECO:0000269|PubMed:10745007, ECO:0000269|PubMed:11675392, ECO:0000269|PubMed:12620235, ECO:0000269|PubMed:18399557, ECO:0000269|PubMed:18756270, ECO:0000269|PubMed:19894725, ECO:0000269|PubMed:21520375, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:8505342}. |
| Tissue Specificity | Most abundant in the heart, brain, spleen and liver. Less in the lung, muscle, kidney and testis; in these tissues less abundant than the beta subunit. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012667 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13928906 | RefSeq | NP_113842 | 567 | geranylgeranyl transferase type-2 subunit alpha |
Identical Sequences to LMP012667 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13928906 | GenBank | EDM14271.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a [Rattus norvegicus] |
| GI:13928906 | GenBank | EDM14272.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a [Rattus norvegicus] |
| GI:13928906 | RefSeq | XP_006252071.1 | 567 | PREDICTED: geranylgeranyl transferase type-2 subunit alpha isoform X1 [Rattus norvegicus] |
| GI:13928906 | RefSeq | XP_006252072.1 | 567 | PREDICTED: geranylgeranyl transferase type-2 subunit alpha isoform X1 [Rattus norvegicus] |
Related Sequences to LMP012667 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13928906 | GenBank | AAH86547.1 | 567 | Rab geranylgeranyltransferase, alpha subunit [Rattus norvegicus] |
| GI:13928906 | GenBank | EDM14271.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a [Rattus norvegicus] |
| GI:13928906 | GenBank | EDM14272.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a [Rattus norvegicus] |