Gene/Proteome Database (LMPD)

LMPD ID
LMP012670
Gene ID
59264
Species
Rattus norvegicus (Rat)
Gene Name
leukotriene B4 receptor
Gene Symbol
Ltb4r
Synonyms
Ltb4r1;
Alternate Names
leukotriene B4 receptor 1; BLT1; BLT-1; LTB4-R1; LTB4-R 1;
Chromosome
15
Map Location
15p13
Summary
may mediate macrophage recruitment and activation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ltb4r

Proteins

leukotriene B4 receptor 1
Refseq ID NP_067688
Protein GI 11067371
UniProt ID Q9R0Q2
mRNA ID NM_021656
Length 351
MAANTTSTAATSSPGGMSLSLLPIVLLSVALVVGLPGNSFVVWSILKRMQKRSVTALLVLNLALADLAVLLTAPFFLHFLARGTWSFEVTGCRLCHYVCGVSMYASVLLITIMSLDRSLAVARPFVSQKVRTKAFARWVLAGIWVVSFLLAIPVLVYRTVTPKNKTLICDSRYPSDGHKVFHLLFEAITGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHLVNLVEAGRTLAGWDKNSPAGQRLKLARYVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVVKLLEGTGSEVSSTRRGGTLVQTPKATPTCPEPGPTDSFMTSSTPPESSK

Gene Information

Entrez Gene ID
59264
Gene Name
leukotriene B4 receptor
Gene Symbol
Ltb4r
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001632 IEA:Ensembl F leukotriene B4 receptor activity
GO:0004974 IDA:RGD F leukotriene receptor activity
GO:0006954 IEP:RGD P inflammatory response

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954203 Leukotriene receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR003981 Leukotriene B4 receptor
IPR003983 Leukotriene B4 type 1 receptor

UniProt Annotations

Entry Information

Gene Name
leukotriene B4 receptor
Protein Entry
LT4R1_RAT
UniProt ID
Q9R0Q2
Species
Rat

Comments

Comment Type Description
Function Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Ptm Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Exclusively expressed in polymorphonuclear leukocytes

Identical and Related Proteins

Unique RefSeq proteins for LMP012670 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11067371 RefSeq NP_067688 351 leukotriene B4 receptor 1

Identical Sequences to LMP012670 proteins

Reference Database Accession Length Protein Name
GI:11067371 GenBank EDM14281.1 351 rCG23458 [Rattus norvegicus]
GI:11067371 RefSeq XP_006252073.1 351 PREDICTED: leukotriene B4 receptor 1 isoform X1 [Rattus norvegicus]
GI:11067371 RefSeq XP_006252074.1 351 PREDICTED: leukotriene B4 receptor 1 isoform X1 [Rattus norvegicus]
GI:11067371 SwissProt Q9R0Q2.1 351 RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1; Short=LTB4-R1 [Rattus norvegicus]

Related Sequences to LMP012670 proteins

Reference Database Accession Length Protein Name
GI:11067371 GenBank EDM14281.1 351 rCG23458 [Rattus norvegicus]
GI:11067371 RefSeq XP_006252073.1 351 PREDICTED: leukotriene B4 receptor 1 isoform X1 [Rattus norvegicus]
GI:11067371 SwissProt Q9R0Q2.1 351 RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1; Short=LTB4-R1 [Rattus norvegicus]