Gene/Proteome Database (LMPD)

LMPD ID
LMP012672
Gene ID
59268
Species
Rattus norvegicus (Rat)
Gene Name
inositol hexakisphosphate kinase 2
Gene Symbol
Ip6k2
Synonyms
Pius; Ihpk2;
Alternate Names
inositol hexakisphosphate kinase 2; InsP6 kinase 2; P(i)-uptake stimulator; inositol hexaphosphate kinase 2;
Chromosome
8
Map Location
8q32
EC Number
2.7.4.21
Summary
activator protein for intestinal Na/Pi co-transport system; may play a role in the regulation of the intestinal Pi transport system by Pi restriction and 1;25-(OH)2D3 [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ip6k2

Proteins

inositol hexakisphosphate kinase 2
Refseq ID NP_067692
Protein GI 158138537
UniProt ID Q9R0U1
mRNA ID NM_021660
Length 425
MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRRFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGPVDIVDNSDCEPKSKLLRWTNKKHHVLETEKSPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVEKKGTVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTCRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPLGASSVDVRMIDFAHTTCRLYGEDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE

Gene Information

Entrez Gene ID
59268
Gene Name
inositol hexakisphosphate kinase 2
Gene Symbol
Ip6k2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0045111 IEA:Ensembl C intermediate filament cytoskeleton
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723 IEA:UniProtKB-EC F inositol hexakisphosphate 1-kinase activity
GO:0052724 IEA:UniProtKB-EC F inositol hexakisphosphate 3-kinase activity
GO:0000832 IEA:UniProtKB-EC F inositol hexakisphosphate 5-kinase activity
GO:0030308 IEA:Ensembl P negative regulation of cell growth
GO:0006817 IDA:RGD P phosphate ion transport
GO:0046854 IEA:Ensembl P phosphatidylinositol phosphorylation
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954517 Synthesis of IPs in the nucleus

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol hexakisphosphate kinase 2
Protein Entry
IP6K2_RAT
UniProt ID
Q9R0U1
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). Was first identified because of its ability to stimulate Na(+)- dependent phosphate cotransport. {ECO:0000250, ECO:0000269|PubMed:10527952}.
Sequence Caution Sequence=BAA87611.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence= ;
Similarity Belongs to the inositol phosphokinase (IPK) family
Subcellular Location Nucleus .
Tissue Specificity Highly expressed in small intestine

Identical and Related Proteins

Unique RefSeq proteins for LMP012672 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158138537 RefSeq NP_067692 425 inositol hexakisphosphate kinase 2

Identical Sequences to LMP012672 proteins

Reference Database Accession Length Protein Name
GI:158138537 GenBank AAH83574.1 425 Inositol hexakisphosphate kinase 2 [Rattus norvegicus]
GI:158138537 GenBank EDL77139.1 425 inositol hexaphosphate kinase 2, isoform CRA_a [Rattus norvegicus]
GI:158138537 RefSeq XP_008764786.1 425 PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Rattus norvegicus]
GI:158138537 SwissProt Q9R0U1.2 425 RecName: Full=Inositol hexakisphosphate kinase 2; Short=InsP6 kinase 2; AltName: Full=P(i)-uptake stimulator; Short=PiUS [Rattus norvegicus]

Related Sequences to LMP012672 proteins

Reference Database Accession Length Protein Name
GI:158138537 GenBank AAH83574.1 425 Inositol hexakisphosphate kinase 2 [Rattus norvegicus]
GI:158138537 GenBank EDL77139.1 425 inositol hexaphosphate kinase 2, isoform CRA_a [Rattus norvegicus]
GI:158138537 RefSeq XP_008764786.1 425 PREDICTED: inositol hexakisphosphate kinase 2 isoform X1 [Rattus norvegicus]