Gene/Proteome Database (LMPD)

LMPD ID
LMP012673
Gene ID
60349
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 5, group A, member 2
Gene Symbol
Nr5a2
Synonyms
Ftf; Lrh-1;
Alternate Names
nuclear receptor subfamily 5 group A member 2; FTZ-F1 beta; FTZ-F1 beta2 protein; liver receptor homolog 1; fetoprotein transcription factor;
Chromosome
13
Map Location
13q13
Summary
an orphan nuclear receptor that may bind DNA and activate gene transcription [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr5a2

Proteins

nuclear receptor subfamily 5 group A member 2
Refseq ID NP_068510
Protein GI 13492975
UniProt ID Q9QWM1
mRNA ID NM_021742
Length 560
MSASSITGDFQDFLKHGLPAIAPAPGSETPHSPKLEEKHREKRAGLPDRHRRPIPARSRLVMLPKVETEASGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHGSLHGYQPYGHFPNRAIKSEYPDPYSSSPESMMGYSYMDGYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQNNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSSIISNTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENFQLVEGVQEQVNAALLDYTLCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA

Gene Information

Entrez Gene ID
60349
Gene Name
nuclear receptor subfamily 5, group A, member 2
Gene Symbol
Nr5a2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 ISS:UniProtKB F DNA binding
GO:0003690 IDA:RGD F double-stranded DNA binding
GO:0004879 IDA:RGD F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 ISS:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ko04950 Maturity onset diabetes of the young
rno04950 Maturity onset diabetes of the young

REACTOME Pathway Links

REACTOME Pathway ID Description
5953533 Developmental Biology
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway
5954071 Regulation of beta-cell development
5954070 Regulation of gene expression in early pancreatic precursor cells

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR016355 Steroidogenic_factor_1
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 5, group A, member 2
Protein Entry
NR5A2_RAT
UniProt ID
Q9QWM1
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=FTZ-F1 beta1; IsoId=Q9QWM1-1; Sequence=Displayed; Name=2; Synonyms=FTZ-F1 beta2; IsoId=Q9QWM1-2; Sequence=VSP_017915;
Function Binds to promoters containing the sequence element 5'- AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity)
Similarity Belongs to the nuclear hormone receptor family. NR5 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus .
Subunit Binds DNA as a monomer. Interacts with GRIP1, NCOA2 and NR0B2 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012673 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13492975 RefSeq NP_068510 560 nuclear receptor subfamily 5 group A member 2

Identical Sequences to LMP012673 proteins

Reference Database Accession Length Protein Name
GI:13492975 DBBJ BAA36339.1 560 FTZ-F1 beta1 [Rattus norvegicus]
GI:13492975 SwissProt Q9QWM1.1 560 RecName: Full=Nuclear receptor subfamily 5 group A member 2; AltName: Full=FTZ-F1 beta; AltName: Full=Liver receptor homolog 1; Short=LRH-1 [Rattus norvegicus]

Related Sequences to LMP012673 proteins

Reference Database Accession Length Protein Name
GI:13492975 DBBJ BAA36339.1 560 FTZ-F1 beta1 [Rattus norvegicus]
GI:13492975 GenBank AAI37846.1 560 Nuclear receptor subfamily 5, group A, member 2 [Mus musculus]
GI:13492975 SwissProt Q9QWM1.1 560 RecName: Full=Nuclear receptor subfamily 5 group A member 2; AltName: Full=FTZ-F1 beta; AltName: Full=Liver receptor homolog 1; Short=LRH-1 [Rattus norvegicus]