Gene/Proteome Database (LMPD)

LMPD ID
LMP012674
Gene ID
60351
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 1, group H, member 4
Gene Symbol
Nr1h4
Synonyms
Fxr;
Alternate Names
bile acid receptor; farnesol receptor HRR-1; RXR-interacting protein 14; farnesoid X activated receptor; farnesoid X-activated receptor; retinoid X receptor-interacting protein 14;
Chromosome
7
Map Location
7q13
Summary
nuclear hormone receptor that is activated by farnesol metabolites [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr1h4

Proteins

bile acid receptor
Refseq ID NP_068513
Protein GI 11120690
UniProt ID Q62735
mRNA ID NM_021745
Length 469
MNLIGPSHLQATDEFALSENLFGVLTEHAAGPLGQNLDLESYSPYNNVQFPQVQPQISSSSYYSNLGFYPQQPEDWYSPGLYELRRMPTESVYQGETEVSEMPVTKKPRMAASSAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQDCRLRKCREMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKLCREKTELTVDQQTLLDYIMDSYSKQRMPQEITNKILKEEFSAEENFLILTEMATSHVQILVEFTKRLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPAGHADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIYQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ

Gene Information

Entrez Gene ID
60351
Gene Name
nuclear receptor subfamily 1, group H, member 4
Gene Symbol
Nr1h4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005719 IEA:Ensembl C nuclear euchromatin
GO:0005634 IDA:RGD C nucleus
GO:0032052 IPI:UniProtKB F bile acid binding
GO:0038181 IDA:UniProtKB F bile acid receptor activity
GO:1902122 IEA:Ensembl F chenodeoxycholic acid binding
GO:0003677 IDA:RGD F DNA binding
GO:0042277 IDA:RGD F peptide binding
GO:0004872 IDA:RGD F receptor activity
GO:0000978 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000980 IEA:Ensembl F RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003705 IEA:Ensembl F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0001190 IEA:Ensembl F RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003707 IDA:RGD F steroid hormone receptor activity
GO:0004887 IEA:InterPro F thyroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0008206 IDA:RGD P bile acid metabolic process
GO:0071229 IEA:Ensembl P cellular response to acid chemical
GO:0071417 IEA:Ensembl P cellular response to organonitrogen compound
GO:0048565 IEP:RGD P digestive tract development
GO:0038185 IEA:Ensembl P intracellular bile acid receptor signaling pathway
GO:0070858 IEA:Ensembl P negative regulation of bile acid biosynthetic process
GO:0000122 IMP:RGD P negative regulation of transcription from RNA polymerase II promoter
GO:2001250 IEA:Ensembl P positive regulation of ammonia assimilation cycle
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0006109 IMP:RGD P regulation of carbohydrate metabolic process
GO:0034255 IEA:Ensembl P regulation of urea metabolic process
GO:0009749 IEP:RGD P response to glucose
GO:0032496 IEP:RGD P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
ko04976 Bile secretion
rno04976 Bile secretion

REACTOME Pathway Links

REACTOME Pathway ID Description
5953720 Bile acid and bile salt metabolism
5953258 Biological oxidations
5953485 Cytochrome P450 - arranged by substrate type
5953932 Endogenous sterols
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953330 Gene Expression
5953833 Generic Transcription Pathway
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954147 Nuclear Receptor transcription pathway
5953326 Phase 1 - Functionalization of compounds
5954333 PPARA activates gene expression
5953719 Recycling of bile acids and salts
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5953930 Synthesis of bile acids and bile salts
5953929 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5953931 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 4
Protein Entry
NR1H4_RAT
UniProt ID
Q62735
Species
Rat

Comments

Comment Type Description
Function Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity)
Induction Heterodimer of NR1H4 and RXR activated by farnesol
Ptm Methylation may increase transactivation of target genes
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus .
Subunit Interacts with CARM1 and SMARD1. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2 (By similarity). Heterodimer of NR1H4 and RXR. {ECO:0000250, ECO:0000269|PubMed:7774010}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012674 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11120690 RefSeq NP_068513 469 bile acid receptor

Identical Sequences to LMP012674 proteins

Reference Database Accession Length Protein Name
GI:11120690 GenBank EDM16986.1 469 nuclear receptor subfamily 1, group H, member 4, isoform CRA_b [Rattus norvegicus]
GI:11120690 GenBank ACN04135.1 469 Sequence 14 from patent US 7482366
GI:11120690 GenBank AEN39526.1 469 Sequence 6 from patent US 7998986
GI:11120690 GenBank AEP73959.1 469 Sequence 14 from patent US 8013001

Related Sequences to LMP012674 proteins

Reference Database Accession Length Protein Name
GI:11120690 GenBank ABA07287.1 469 Sequence 1 from patent US 6906057
GI:11120690 GenBank ACN04135.1 469 Sequence 14 from patent US 7482366
GI:11120690 GenBank AEN39526.1 469 Sequence 6 from patent US 7998986