Gene/Proteome Database (LMPD)

LMPD ID
LMP012676
Gene ID
60418
Species
Rattus norvegicus (Rat)
Gene Name
glycerophosphodiester phosphodiesterase 1
Gene Symbol
Gde1
Synonyms
Mir16;
Alternate Names
glycerophosphodiester phosphodiesterase 1; membrane interacting protein of RGS16; membrane-interacting protein of RGS16;
Chromosome
1
Map Location
chromosome:1
EC Number
3.1.4.44
Summary
a putative membrane glycerophosphodiester phosphodiesterase; may mediate lipid metabolism and G protein signaling [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gde1

Proteins

glycerophosphodiester phosphodiesterase 1
Refseq ID NP_116004
Protein GI 47575864
UniProt ID Q9JL55
mRNA ID NM_032615
Length 331
MWLWEDQGGLLGPFSFVLVLLLVVTRSPFNACVLTGSLYLLLRFFSFEPVPSRRALQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGVPVLMHDNTVDRTTDGSGRLCDLTFEQVRKLNPAANHRLRNEFPDERIPTLREAVTECLCHNLTIFFDVKGHADMASAALKNIYMEFPQLYNNSMVCSFLPEVIYKMRQTDQKVITALTHRPWSLSHTGDGKPRYSVFWKQSVFVVLDILLDWSMHNVLWYLCGISAFLMQKDFVSPDYLKKWSAKGIQVVSWTVNTFDEKNYYESHLGSSYITDSMLEDCAPHF

Gene Information

Entrez Gene ID
60418
Gene Name
glycerophosphodiester phosphodiesterase 1
Gene Symbol
Gde1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016021 IDA:RGD C integral component of membrane
GO:0008889 IEA:InterPro F glycerophosphodiester phosphodiesterase activity
GO:0047395 IEA:UniProtKB-EC F glycerophosphoinositol glycerophosphodiesterase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0007186 NAS:RGD P G-protein coupled receptor signaling pathway
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase 1
Protein Entry
GDE1_RAT
UniProt ID
Q9JL55
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=12 mM for glycerophosphoinositol ; Vmax=3000 pmol/min/mg enzyme ; Note=Measured in the presence of 10 mM magnesium chloride at 37 degrees Celsius.;
Catalytic Activity 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Function Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways
Ptm N-glycosylated
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family
Similarity Contains 1 GP-PDE domain
Subcellular Location Cytoplasm. Membrane; Multi-pass membrane protein. Note=Perinuclear vesicles and cell membrane.
Subunit Interacts with PRAF2 (By similarity). Interacts with RGS16
Tissue Specificity Detected in heart, brain, lung, liver, skeletal muscle, kidney, pituitary and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012676 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47575864 RefSeq NP_116004 331 glycerophosphodiester phosphodiesterase 1

Identical Sequences to LMP012676 proteins

Reference Database Accession Length Protein Name
GI:47575864 GenBank AAH70897.1 331 Glycerophosphodiester phosphodiesterase 1 [Rattus norvegicus]
GI:47575864 GenBank EDM17698.1 331 membrane interacting protein of RGS16, isoform CRA_b [Rattus norvegicus]
GI:47575864 SwissProt Q9JL55.2 331 RecName: Full=Glycerophosphodiester phosphodiesterase 1; AltName: Full=Membrane-interacting protein of RGS16 [Rattus norvegicus]

Related Sequences to LMP012676 proteins

Reference Database Accession Length Protein Name
GI:47575864 GenBank AAH70897.1 331 Glycerophosphodiester phosphodiesterase 1 [Rattus norvegicus]
GI:47575864 GenBank EDM17698.1 331 membrane interacting protein of RGS16, isoform CRA_b [Rattus norvegicus]
GI:47575864 SwissProt Q9JL55.2 331 RecName: Full=Glycerophosphodiester phosphodiesterase 1; AltName: Full=Membrane-interacting protein of RGS16 [Rattus norvegicus]