Gene/Proteome Database (LMPD)
LMPD ID
LMP012677
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
protein arginine methyltransferase 1
Gene Symbol
Synonyms
Hrmt1l2;
Alternate Names
protein arginine N-methyltransferase 1; histone-arginine N-methyltransferase PRMT1; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2;
Chromosome
1
Map Location
1q22
EC Number
2.1.1.-
Summary
catalyzes protein methyltransferase modification of arginine residues [RGD, Feb 2006]
Orthologs
Proteins
| protein arginine N-methyltransferase 1 | |
|---|---|
| Refseq ID | NP_077339 |
| Protein GI | 13242255 |
| UniProt ID | Q63009 |
| mRNA ID | NM_024363 |
| Length | 353 |
| MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR | |
Gene Information
Entrez Gene ID
Gene Name
protein arginine methyltransferase 1
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:UniProtKB | C | cytosol |
| GO:0005634 | IDA:RGD | C | nucleus |
| GO:0043234 | IDA:RGD | C | protein complex |
| GO:0008757 | TAS:RGD | F | S-adenosylmethionine-dependent methyltransferase activity |
| GO:0016275 | IDA:MGI | F | [cytochrome c]-arginine N-methyltransferase activity |
| GO:0044020 | ISS:UniProtKB | F | histone methyltransferase activity (H4-R3 specific) |
| GO:0008469 | IDA:MGI | F | histone-arginine N-methyltransferase activity |
| GO:0042802 | IPI:IntAct | F | identical protein binding |
| GO:0008276 | IDA:UniProtKB | F | protein methyltransferase activity |
| GO:0016274 | IDA:RGD | F | protein-arginine N-methyltransferase activity |
| GO:0035242 | IDA:MGI | F | protein-arginine omega-N asymmetric methyltransferase activity |
| GO:0035241 | IDA:MGI | F | protein-arginine omega-N monomethyltransferase activity |
| GO:0030519 | IDA:RGD | F | snoRNP binding |
| GO:0043985 | ISS:UniProtKB | P | histone H4-R3 methylation |
| GO:0045653 | ISS:UniProtKB | P | negative regulation of megakaryocyte differentiation |
| GO:0018216 | IDA:RGD | P | peptidyl-arginine methylation |
| GO:0019919 | IDA:MGI | P | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine |
| GO:0035247 | IDA:MGI | P | peptidyl-arginine omega-N-methylation |
| GO:0006479 | IDA:MGI | P | protein methylation |
| GO:0006355 | IBA:RefGenome | P | regulation of transcription, DNA-templated |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| rno04068 | FoxO signaling pathway |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]. |
| Function | Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. {ECO:0000269|PubMed:12737817, ECO:0000269|PubMed:15837430, ECO:0000269|PubMed:18492485}. |
| Interaction | Self; NbExp=2; IntAct=EBI-78708, EBI-78708; P62633:CNBP (xeno); NbExp=2; IntAct=EBI-78708, EBI-1047529; Q9JIL3:Ilf3; NbExp=2; IntAct=EBI-78708, EBI-78714; |
| Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family |
| Similarity | Contains 1 SAM-dependent MTase PRMT-type domain |
| Subcellular Location | Nucleus . Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytosol . Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity) |
| Subunit | Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with NFATC2IP. Interacts with ILF3 and SUPT5H. Interacts with FOXO1; the interaction methylates FOXO1, retaining it in the nucleus and increasing its transcriptional activity. Methylation of FOXO1 is increased with oxidative stress. Interacts with CHTOP; the interaction methylates CHTOP, enabling its interaction with the 5FMC complex (By similarity). Interacts with BTG1, BTG2 and IFNAR1. {ECO:0000250, ECO:0000269|PubMed:12737817, ECO:0000269|PubMed:8663146}. |
| Tissue Specificity | Ubiquitous. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012677 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13242255 | RefSeq | NP_077339 | 353 | protein arginine N-methyltransferase 1 |
Identical Sequences to LMP012677 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13242255 | GenBank | AED35487.1 | 353 | Sequence 150 from patent US 7879989 |
| GI:13242255 | RefSeq | NP_001239405.1 | 353 | protein arginine N-methyltransferase 1 isoform 2 [Mus musculus] |
| GI:13242255 | RefSeq | XP_004672289.1 | 353 | PREDICTED: protein arginine N-methyltransferase 1 isoform X2 [Jaculus jaculus] |
| GI:13242255 | RefSeq | XP_008843307.1 | 353 | PREDICTED: protein arginine N-methyltransferase 1 isoform X2 [Nannospalax galili] |
Related Sequences to LMP012677 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13242255 | GenBank | AAF37293.1 | 353 | protein arginine N-methyltransferase 1 [Mus musculus] |
| GI:13242255 | GenBank | ABW48486.1 | 353 | Sequence 9 from patent US 7264945 |
| GI:13242255 | GenBank | AED35487.1 | 353 | Sequence 150 from patent US 7879989 |