Gene/Proteome Database (LMPD)

LMPD ID
LMP012679
Gene ID
60664
Species
Rattus norvegicus (Rat)
Gene Name
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Gene Symbol
Pik3r3
Alternate Names
phosphatidylinositol 3-kinase regulatory subunit gamma; p55PIK; ptdIns-3-kinase p85-gamma; PI3-kinase p85 subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; PI3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase p55 subunit; ptdIns-3-kinase regulatory subunit p55-gamma; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55);
Chromosome
5
Map Location
5q36
Summary
regulatory subunit of phosphatidylinositol 3-kinase, a mediator of various cellular signaling mechanisms; may mediate signaling in brain and muscle [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pik3r3

Proteins

phosphatidylinositol 3-kinase regulatory subunit gamma
Refseq ID NP_071549
Protein GI 11559994
UniProt ID Q63789
mRNA ID NM_022213
Length 461
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPVTSAVTNGMKDCFVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGNYGFSEPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKSEDTDESYFINEDDESLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKPCVIYSPARGYGFAEPYNLYGSLKELVLHYQQTSLVQHNDSLNVTLAYPVHAQMPSLCR

Gene Information

Entrez Gene ID
60664
Gene Name
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Gene Symbol
Pik3r3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005942 IEA:InterPro C phosphatidylinositol 3-kinase complex
GO:0046935 IDA:RGD F 1-phosphatidylinositol-3-kinase regulator activity
GO:0043551 IDA:GOC P regulation of phosphatidylinositol 3-kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko04960 Aldosterone-regulated sodium reabsorption
rno04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko04210 Apoptosis
rno04210 Apoptosis
ko05100 Bacterial invasion of epithelial cells
rno05100 Bacterial invasion of epithelial cells
ko04662 B cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04973 Carbohydrate digestion and absorption
rno04973 Carbohydrate digestion and absorption
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko05210 Colorectal cancer
rno05210 Colorectal cancer
ko05213 Endometrial cancer
rno05213 Endometrial cancer
ko05169 Epstein-Barr virus infection
rno05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
rno04068 FoxO signaling pathway
ko05214 Glioma
rno05214 Glioma
rno05161 Hepatitis B
ko05160 Hepatitis C
rno05160 Hepatitis C
rno04066 HIF-1 signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko05164 Influenza A
rno05164 Influenza A
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko04670 Leukocyte transendothelial migration
rno04670 Leukocyte transendothelial migration
ko05162 Measles
rno05162 Measles
ko05218 Melanoma
rno05218 Melanoma
ko04150 mTOR signaling pathway
rno04150 mTOR signaling pathway
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko05212 Pancreatic cancer
rno05212 Pancreatic cancer
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
rno04611 Platelet activation
ko04914 Progesterone-mediated oocyte maturation
rno04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05215 Prostate cancer
rno05215 Prostate cancer
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton
ko05211 Renal cell carcinoma
rno05211 Renal cell carcinoma
ko04550 Signaling pathways regulating pluripotency of stem cells
rno04550 Signaling pathways regulating pluripotency of stem cells
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko04660 T cell receptor signaling pathway
rno04660 T cell receptor signaling pathway
rno04919 Thyroid hormone signaling pathway
ko04668 TNF signaling pathway
rno04668 TNF signaling pathway
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko04930 Type II diabetes mellitus
rno04930 Type II diabetes mellitus
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953536 Cytokine Signaling in Immune system
5953410 Immune System
5954308 Interleukin-7 signaling
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954478 PI Metabolism
5953535 Signaling by Interleukins
5954499 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR001720 PI3 kinase, P85 regulatory subunit
IPR000980 SH2 domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Protein Entry
P55G_RAT
UniProt ID
Q63789
Species
Rat

Comments

Comment Type Description
Function Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Similarity Belongs to the PI3K p85 subunit family
Similarity Contains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subunit Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity)
Tissue Specificity Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen.

Identical and Related Proteins

Unique RefSeq proteins for LMP012679 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11559994 RefSeq NP_071549 461 phosphatidylinositol 3-kinase regulatory subunit gamma

Identical Sequences to LMP012679 proteins

Reference Database Accession Length Protein Name
GI:11559994 DBBJ BAA10927.1 461 phosphatidylinositol 3-kinase p55 subunit [Rattus norvegicus]
GI:11559994 SwissProt Q63789.1 461 RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma; Short=PI3-kinase regulatory subunit gamma; Short=PI3K regulatory subunit gamma; Short=PtdIns-3-kinase regulatory subunit gamma; AltName: Full=Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Short=PI3-kinase subunit p55-gamma; Short=PtdIns-3-kinase regulatory subunit p55-gamma; AltName: Full=p55PIK [Rattus norvegicus]

Related Sequences to LMP012679 proteins

Reference Database Accession Length Protein Name
GI:11559994 DBBJ BAA10927.1 461 phosphatidylinositol 3-kinase p55 subunit [Rattus norvegicus]
GI:11559994 RefSeq XP_008762201.1 461 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [Rattus norvegicus]
GI:11559994 SwissProt Q63789.1 461 RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma; Short=PI3-kinase regulatory subunit gamma; Short=PI3K regulatory subunit gamma; Short=PtdIns-3-kinase regulatory subunit gamma; AltName: Full=Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Short=PI3-kinase subunit p55-gamma; Short=PtdIns-3-kinase regulatory subunit p55-gamma; AltName: Full=p55PIK [Rattus norvegicus]