Gene/Proteome Database (LMPD)

LMPD ID
LMP012680
Gene ID
60666
Species
Rattus norvegicus (Rat)
Gene Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Gene Symbol
Gpd1
Synonyms
GPDH; Gpd3;
Alternate Names
glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; GPD-C; GPDH-C; glycerol 3-phosphate dehydrogenase; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic;
Chromosome
7
Map Location
chromosome:7
EC Number
1.1.1.8;
Summary
a mitochondrial glycerol 3-phosphate dehydrogenase active in testis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gpd1

Proteins

glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Refseq ID NP_071551
Protein GI 57527919
UniProt ID O35077
mRNA ID NM_022215
Length 349
MAGKKVCIVGSGNWGSAIAKIVGSNASQLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAATGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGIDEGPNGLKLISEVIGESLGIPMSVLMGANIASEVAEEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQPVGEFICCLQNHPEHM

Gene Information

Entrez Gene ID
60666
Gene Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Gene Symbol
Gpd1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0005739 IEA:Ensembl C mitochondrion
GO:0004368 IDA:RGD F glycerol-3-phosphate dehydrogenase activity
GO:0004367 IDA:RGD F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0051287 IDA:RGD F NAD binding
GO:0005975 IDA:RGD P carbohydrate metabolic process
GO:0071320 IEA:Ensembl P cellular response to cAMP
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0006094 IEA:Ensembl P gluconeogenesis
GO:0046168 IEA:InterPro P glycerol-3-phosphate catabolic process
GO:0006072 IDA:RGD P glycerol-3-phosphate metabolic process
GO:0046486 IDA:RGD P glycerolipid metabolic process
GO:0006127 IEA:Ensembl P glycerophosphate shuttle
GO:0006734 IDA:RGD P NADH metabolic process
GO:0006116 IDA:RGD P NADH oxidation
GO:0045821 IEA:Ensembl P positive regulation of glycolytic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5953472 Synthesis of PA
5953464 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase 1 (soluble)
Protein Entry
GPDA_RAT
UniProt ID
O35077
Species
Rat

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family
Subcellular Location Cytoplasm.
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012680 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57527919 RefSeq NP_071551 349 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Identical Sequences to LMP012680 proteins

Reference Database Accession Length Protein Name
GI:57527919 GenBank AAH88396.1 349 Glycerol-3-phosphate dehydrogenase 1 (soluble) [Rattus norvegicus]
GI:57527919 GenBank EDL86970.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble), isoform CRA_a [Rattus norvegicus]
GI:57527919 RefSeq XP_006257438.1 349 PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [Rattus norvegicus]
GI:57527919 SwissProt O35077.4 349 RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; Short=GPD-C; Short=GPDH-C [Rattus norvegicus]

Related Sequences to LMP012680 proteins

Reference Database Accession Length Protein Name
GI:57527919 GenBank EDL86970.1 349 glycerol-3-phosphate dehydrogenase 1 (soluble), isoform CRA_a [Rattus norvegicus]
GI:57527919 RefSeq XP_006257438.1 349 PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform X1 [Rattus norvegicus]
GI:57527919 SwissProt O35077.4 349 RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; Short=GPD-C; Short=GPDH-C [Rattus norvegicus]