Gene/Proteome Database (LMPD)

LMPD ID
LMP012690
Gene ID
64161
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
Gene Symbol
Pi4ka
Synonyms
Pik4ca;
Alternate Names
phosphatidylinositol 4-kinase alpha; PI4K-alpha; leuserpin 2; PI4-kinase alpha; ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase a; phosphatidylinositol 4-kinase, catalytic, alpha polypeptide;
Chromosome
11
Map Location
11q23
EC Number
2.7.1.67;
Summary
catalyzes the phosphorylation of phosphatidylinositol (PI) at the D-4 position of inositol ring [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pi4ka

Proteins

phosphatidylinositol 4-kinase alpha
Refseq ID NP_071637
Protein GI 25742825
UniProt ID O08662
mRNA ID NM_022301
Length 2041
MCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCIVPYLLRLLRGLPKVYWVEESTARKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEALLQVLHVLLGMCQALEIQEKEYLCKYAIPCLIGISKSFGRYSNSEESLLSKLFPKVPPHSLRIPEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPEYYFSTISSSFSVSPLFNGITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEANPSADLYYTTFSDPVYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKISVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSAETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEADGKKICWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIPY

Gene Information

Entrez Gene ID
64161
Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
Gene Symbol
Pi4ka
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030660 IDA:RGD C Golgi-associated vesicle membrane
GO:0005886 IBA:RefGenome C plasma membrane
GO:0004430 IDA:RGD F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954501 Synthesis of PIPs at the ER membrane
5954502 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase, catalytic, alpha
Protein Entry
PI4KA_RAT
UniProt ID
O08662
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Developmental Stage In brain of prenatal day 18 embryos, the expression is detected throughout the mantle zone of fore-, mid-, and hind brain. In the cerebrum, the expression is intense in the cortical plate and weak in the ventricular zone. At P49, expressed in the gray matter of the entire brain by hippocampal pyramidal cells, dentate granule cells, and cerebellar granule cells and to a lower extent by olfactory mitral and granule cells and the cerebral cortex. Weakly expressed in the diencephalon and brain stem and not detected in the cerebellar medulla. Expression is much higher in the fetal brain than the adult brain, especially in the brain stem.
Enzyme Regulation Activated by Triton X-100, insensitive to inhibition by adenosine and inhibited by wortmannin
Function Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate.
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Cytoplasm . Membrane . Note=Associates with the membranes of Golgi vesicles and vacuoles.
Tissue Specificity Detected in the brain, kidney and lung. Less intensely expressed in the small intestine, uterus, adrenal gland, heart, skeletal muscle, thymus, spleen and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012690 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25742825 RefSeq NP_071637 2041 phosphatidylinositol 4-kinase alpha

Identical Sequences to LMP012690 proteins

Reference Database Accession Length Protein Name
GI:25742825 DBBJ BAA19614.1 2041 230kDa phosphatidylinositol 4-kinase [Rattus norvegicus]
GI:25742825 SwissProt O08662.1 2041 RecName: Full=Phosphatidylinositol 4-kinase alpha; Short=PI4-kinase alpha; Short=PI4K-alpha; Short=PtdIns-4-kinase alpha [Rattus norvegicus]

Related Sequences to LMP012690 proteins

Reference Database Accession Length Protein Name
GI:25742825 DBBJ BAA19614.1 2041 230kDa phosphatidylinositol 4-kinase [Rattus norvegicus]
GI:25742825 RefSeq XP_008767124.1 2114 PREDICTED: phosphatidylinositol 4-kinase alpha isoform X1 [Rattus norvegicus]
GI:25742825 SwissProt O08662.1 2041 RecName: Full=Phosphatidylinositol 4-kinase alpha; Short=PI4-kinase alpha; Short=PI4K-alpha; Short=PtdIns-4-kinase alpha [Rattus norvegicus]