Gene/Proteome Database (LMPD)

LMPD ID
LMP012692
Gene ID
64191
Species
Rattus norvegicus (Rat)
Gene Name
7-dehydrocholesterol reductase
Gene Symbol
Dhcr7
Alternate Names
7-dehydrocholesterol reductase; 7-DHC reductase; sterol Delta(7)-reductase;
Chromosome
1
Map Location
1q41
EC Number
1.3.1.21
Summary
catalyzes the reduction of 7-dehydrocholesterol and involved in cholesterol biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dhcr7

Proteins

7-dehydrocholesterol reductase
Refseq ID NP_071784
Protein GI 11693158
UniProt ID Q9Z2Z8
mRNA ID NM_022389
Length 471
MASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLLFAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYVAAVPYRLLPGIF

Gene Information

Entrez Gene ID
64191
Gene Name
7-dehydrocholesterol reductase
Gene Symbol
Dhcr7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005640 IEA:Ensembl C nuclear outer membrane
GO:0047598 IMP:RGD F 7-dehydrocholesterol reductase activity
GO:0001568 IEA:Ensembl P blood vessel development
GO:0030154 IEA:Ensembl P cell differentiation
GO:0006695 IDA:RGD P cholesterol biosynthetic process
GO:0030324 IEA:Ensembl P lung development
GO:0035264 IEA:Ensembl P multicellular organism growth
GO:0009791 IEA:Ensembl P post-embryonic development
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0045540 IDA:RGD P regulation of cholesterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
rno01100 Metabolic pathways
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)

Domain Information

InterPro Annotations

Accession Description
IPR001171 Ergosterol biosynthesis ERG4/ERG24
IPR018083 Sterol reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
7-dehydrocholesterol reductase
Protein Entry
DHCR7_RAT
UniProt ID
Q9Z2Z8
Species
Rat

Comments

Comment Type Description
Catalytic Activity Cholesterol + NADP(+) = cholesta-5,7-dien-3- beta-ol + NADPH.
Function Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
Pathway Steroid biosynthesis; cholesterol biosynthesis.
Similarity Belongs to the ERG4/ERG24 family
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012692 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11693158 RefSeq NP_071784 471 7-dehydrocholesterol reductase

Identical Sequences to LMP012692 proteins

Reference Database Accession Length Protein Name
GI:11693158 RefSeq XP_006230956.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X1 [Rattus norvegicus]
GI:11693158 RefSeq XP_008758393.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X1 [Rattus norvegicus]
GI:11693158 RefSeq XP_008758394.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X1 [Rattus norvegicus]
GI:11693158 RefSeq XP_008758395.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X1 [Rattus norvegicus]

Related Sequences to LMP012692 proteins

Reference Database Accession Length Protein Name
GI:11693158 GenBank AAD31383.1 471 7-dehydrocholesterol reductase [Rattus norvegicus]
GI:11693158 GenBank AAM45144.1 471 7-dehydrocholesterol reductase [Rattus norvegicus]
GI:11693158 GenBank AAH81688.1 471 7-dehydrocholesterol reductase [Rattus norvegicus]