Gene/Proteome Database (LMPD)

LMPD ID
LMP012698
Gene ID
64355
Species
Rattus norvegicus (Rat)
Gene Name
lipolysis stimulated lipoprotein receptor
Gene Symbol
Lsr
Synonyms
Lisch7;
Alternate Names
lipolysis-stimulated lipoprotein receptor; lipolysis-stimulated receptor; lipolysis-stimulated remnant receptor; liver-specific bHLH-Zip transcription factor 7;
Chromosome
1
Map Location
1q21
Summary
binds apoB, apoE, and triglyceride-rich lipoprotein (chylomicrons and very low density lipoprotein (VLDL)); may mediate the partitioning of dietary lipid between different tissues [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lsr

Proteins

lipolysis-stimulated lipoprotein receptor precursor
Refseq ID NP_116005
Protein GI 14249140
UniProt ID Q9WU74
mRNA ID NM_032616
Length 593
MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPASAIQVTVSDPYHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPRSRQRSRDPRDAGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
sig_peptide: 1..35 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q9WU74.1) calculated_mol_wt: 3461 peptide sequence: MAPAAGACAGAPDSHPATVVFVCLFLIIFCPDPAS mat_peptide: 36..593 product: Lipolysis-stimulated lipoprotein receptor experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9WU74.1) calculated_mol_wt: 62334 peptide sequence: AIQVTVSDPYHVVILFQPVTLPCTYQMSNTLTVPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFEQTAWGDSGVYYCSVVSAQDLDGNNEAYAELIVLGRTSEAPELLPGFRAGPLEDWLFVVVVCLASLLLFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSIYTHLSPAKTPPPPPAMIPMGPPYGYPGDFDRHSSVGGHSSQVPLLRDVDGSVSSEVRSGYRIQANQQDDSMRVLYYMEKELANFDPSRPGPPNGRVERAMSEVTSLHEDDWRSRPSRAPALTPIRDEEWNRHSPQSPRTWEQEPLQEQPRGGWGSGRPRARSVDALDDINRPGSTESGRSSPPSSGRRGRAYAPPRSRSRDDLYDPDDPRDLPHSRDPHYYDDIRSRDPRADPRSRQRSRDPRDAGFRSRDPQYDGRLLEEALKKKGSGERRRVYREEEEEEEGQYPPAPPPYSETDSQASRERRLKKNLALSRESLVV

Gene Information

Entrez Gene ID
64355
Gene Name
lipolysis stimulated lipoprotein receptor
Gene Symbol
Lsr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034362 IEA:UniProtKB-KW C low-density lipoprotein particle
GO:0005886 ISS:HGNC C plasma membrane
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0005504 TAS:HGNC F fatty acid binding
GO:0017129 TAS:HGNC F triglyceride binding
GO:0009790 ISS:HGNC P embryo development
GO:0001889 ISS:HGNC P liver development
GO:0019216 IDA:RGD P regulation of lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR003599 Immunoglobulin subtype
IPR013783 Immunoglobulin-like fold
IPR008664 LISCH7

UniProt Annotations

Entry Information

Gene Name
lipolysis stimulated lipoprotein receptor
Protein Entry
LSR_RAT
UniProt ID
Q9WU74
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=alpha; IsoId=Q9WU74-1; Sequence=Displayed; Name=2; Synonyms=alpha'; IsoId=Q9WU74-2; Sequence=VSP_019698; Name=3; Synonyms=beta; IsoId=Q9WU74-3; Sequence=VSP_019697;
Function Probable role in the clearance of triglyceride-rich lipoprotein from plasma. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells
Similarity Belongs to the immunoglobulin superfamily. LISCH7 family
Similarity Contains 1 Ig-like V-type (immunoglobulin-like) domain
Subcellular Location Cell membrane ; Single-pass type I membrane protein .
Subunit Homotrimer or homotetramer constituted of isoform 1 and/or isoform 2 and isoform 3
Tissue Specificity Specifically expressed in liver. Also detected in kidney and lung

Identical and Related Proteins

Unique RefSeq proteins for LMP012698 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14249140 RefSeq NP_116005 593 lipolysis-stimulated lipoprotein receptor precursor

Identical Sequences to LMP012698 proteins

Reference Database Accession Length Protein Name
GI:14249140 GenBank EDM07691.1 593 lipolysis stimulated lipoprotein receptor, isoform CRA_a [Rattus norvegicus]
GI:14249140 GenBank ABX97971.1 593 Sequence 2 from patent US 7291709
GI:14249140 GenBank ACM96522.1 593 Sequence 9 from patent US 7470669
GI:14249140 GenBank AED79451.1 593 Sequence 2 from patent US 7919091

Related Sequences to LMP012698 proteins

Reference Database Accession Length Protein Name
GI:14249140 GenBank AAD30028.1 593 lipolysis-stimulated remnant receptor alpha subunit [Rattus norvegicus]
GI:14249140 GenBank EDM07691.1 593 lipolysis stimulated lipoprotein receptor, isoform CRA_a [Rattus norvegicus]
GI:14249140 GenBank AED79451.1 593 Sequence 2 from patent US 7919091