Gene/Proteome Database (LMPD)

LMPD ID
LMP012699
Gene ID
64364
Species
Rattus norvegicus (Rat)
Gene Name
plasmolipin
Gene Symbol
Pllp
Synonyms
Tm4sf11;
Alternate Names
plasmolipin; transmembrane 4 superfamily member 11; plasma membrane proteolipid (plasmolipin);
Chromosome
19
Map Location
19p12
Summary
induces the formation of voltage dependent K+ selective ion channels in lipid bilayers; may play a role in myelination [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pllp

Proteins

plasmolipin
Refseq ID NP_071978
Protein GI 11968122
UniProt ID P47987
mRNA ID NM_022533
Length 182
MAEFPSKVSTRTSSPAQGVGASVSAMRPDLGFVRSALGVLALLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVFFIIYLFQLHMKLYMVPWPLVLLVFFVAATVLYITAFVACAAAVDLTSLRGSRPYNQRSAASFFACLVMIAYGLSAFFSFQAWRGVGSNAATSQMAGGYS

Gene Information

Entrez Gene ID
64364
Gene Name
plasmolipin
Gene Symbol
Pllp
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043218 IDA:RGD C compact myelin
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0045121 IDA:RGD C membrane raft
GO:0006811 IDA:RGD P ion transport
GO:0042552 IEP:RGD P myelination
GO:0009611 IEP:RGD P response to wounding

Domain Information

InterPro Annotations

Accession Description
IPR008253 Marvel domain
IPR013295 Myelin and lymphocyte (MAL) protein

UniProt Annotations

Entry Information

Gene Name
plasmolipin
Protein Entry
PLLP_RAT
UniProt ID
P47987
Species
Rat

Comments

Comment Type Description
Developmental Stage In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.
Function Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective.
Sequence Caution Sequence=AAA62133.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the MAL family
Similarity Contains 1 MARVEL domain. {ECO:0000255|PROSITE- ProRule:PRU00581}.
Subcellular Location Membrane ; Multi-pass membrane protein .
Subunit Hexamer arranged as a trimer of two plasmolipin subunits.
Tissue Specificity Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tublar epithelia.

Identical and Related Proteins

Unique RefSeq proteins for LMP012699 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11968122 RefSeq NP_071978 182 plasmolipin

Identical Sequences to LMP012699 proteins

Reference Database Accession Length Protein Name
GI:11968122 EMBL CAA90017.1 182 plasmolipin [Rattus norvegicus]
GI:11968122 GenBank AAH78823.1 182 Plasma membrane proteolipid (plasmolipin) [Rattus norvegicus]
GI:11968122 SwissProt P47987.2 182 RecName: Full=Plasmolipin; AltName: Full=Plasma membrane proteolipid [Rattus norvegicus]

Related Sequences to LMP012699 proteins

Reference Database Accession Length Protein Name
GI:11968122 EMBL CAA90017.1 182 plasmolipin [Rattus norvegicus]
GI:11968122 GenBank AAH78823.1 182 Plasma membrane proteolipid (plasmolipin) [Rattus norvegicus]
GI:11968122 SwissProt P47987.2 182 RecName: Full=Plasmolipin; AltName: Full=Plasma membrane proteolipid [Rattus norvegicus]