Gene/Proteome Database (LMPD)

LMPD ID
LMP012707
Gene ID
64511
Species
Rattus norvegicus (Rat)
Gene Name
farnesyltransferase, CAAX box, beta
Gene Symbol
Fntb
Alternate Names
protein farnesyltransferase subunit beta; FTase-beta; farnesyltransferase beta subunit; CAAX farnesyltransferase subunit beta; ras proteins prenyltransferase subunit beta;
Chromosome
6
Map Location
6q24
EC Number
2.5.1.58
Summary
beta subunit of a transferase enzyme; attaches a farnesyl group to cysteine in ras and other membrane-associated proteins [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Fntb

Proteins

protein farnesyltransferase subunit beta
Refseq ID NP_742031
Protein GI 25282399
UniProt ID Q02293
mRNA ID NM_172034
Length 437
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD

Gene Information

Entrez Gene ID
64511
Gene Name
farnesyltransferase, CAAX box, beta
Gene Symbol
Fntb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005875 IEA:Ensembl C microtubule associated complex
GO:0043234 IDA:RGD C protein complex
GO:0005965 ISS:UniProtKB C protein farnesyltransferase complex
GO:0004311 IEA:Ensembl F farnesyltranstransferase activity
GO:0004660 IDA:RGD F protein farnesyltransferase activity
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0045787 IMP:RGD P positive regulation of cell cycle
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0051770 IMP:RGD P positive regulation of nitric-oxide synthase biosynthetic process
GO:0018343 ISS:UniProtKB P protein farnesylation
GO:0034097 IMP:RGD P response to cytokine
GO:0010035 IMP:RGD P response to inorganic substance
GO:0014070 IMP:RGD P response to organic cyclic compound
GO:0042060 IEA:Ensembl P wound healing

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953253 Disease
5953382 Diseases associated with visual transduction
5953378 Inactivation, recovery and regulation of the phototransduction cascade
5953381 Signal Transduction
5953379 The phototransduction cascade
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR026872 Protein farnesyltransferase subunit beta
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
farnesyltransferase, CAAX box, beta
Protein Entry
FNTB_RAT
UniProt ID
Q02293
Species
Rat

Comments

Comment Type Description
Catalytic Activity Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:22963166}.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427};
Function Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:22963166}.
Interaction Q04631:Fnta; NbExp=14; IntAct=EBI-602454, EBI-602447;
Similarity Belongs to the protein prenyltransferase subunit beta family
Similarity Contains 5 PFTB repeats
Subunit Heterodimer of FNTA and FNTB. {ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9065406, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012707 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25282399 RefSeq NP_742031 437 protein farnesyltransferase subunit beta

Identical Sequences to LMP012707 proteins

Reference Database Accession Length Protein Name
GI:25282399 PDB 3.00E+33 437 Chain B, Protein Farnesyltransferase Complexed With Fpp And Ethylenediamine Scaffold Inhibitor 7
GI:25282399 PDB 3.00E+34 437 Chain B, Protein Farnesyltransferase Complexed With Fpp And Ethylenediamine-Scaffold Inhibitor 10
GI:25282399 PDB 3KSL 437 Chain B, Structure Of Fpt Bound To Datfp-Dh-Gpp
GI:25282399 PDB 3KSQ 437 Chain B, Discovery Of C-Imidazole Azaheptapyridine Fpt Inhibitors

Related Sequences to LMP012707 proteins

Reference Database Accession Length Protein Name
GI:25282399 PDB 1FPP 437 Chain B, Protein Farnesyltransferase Complex With Farnesyl Diphosphate
GI:25282399 PDB 1QBQ 437 Chain B, Structure Of Rat Farnesyl Protein Transferase Complexed With A Cvim Peptide And Alpha-Hydroxyfarnesylphosphonic Acid.
GI:25282399 PDB 1D8D 437 Chain B, Co-Crystal Structure Of Rat Protein Farnesyltransferase Complexed With A K-Ras4b Peptide Substrate And Fpp Analog At 2.0a Resolution