Gene/Proteome Database (LMPD)

LMPD ID
LMP012709
Gene ID
64526
Species
Rattus norvegicus (Rat)
Gene Name
enoyl CoA hydratase 1, peroxisomal
Gene Symbol
Ech1
Synonyms
Pxel;
Alternate Names
delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Peroxisomal enoyl hydratase-like protein; enoyl hydratase-like protein peroxisomal; enoyl coenzyme A hydratase 1, peroxisomal; enoyl hydratase-like protein, peroxisomal;
Chromosome
1
Map Location
1q21
EC Number
5.3.3.-
Summary
isomerase enzyme that may be involved with the ability of peroxisomes to oxidize long-chain faty acids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ech1

Proteins

delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor
Refseq ID NP_072116
Protein GI 12018256
UniProt ID Q62651
mRNA ID NM_022594
Length 327
MATAMTVSSKLLGLLMQQLRGTRQLYFNVSLRSLSSSAQEASKRIPEEVSDHNYESIQVTSAQKHVLHVQLNRPEKRNAMNRAFWRELVECFQKISKDSDCRAVVVSGAGKMFTSGIDLMDMASDILQPPGDDVARIAWYLRDLISRYQKTFTVIEKCPKPVITAIHGGCIGGGVDLISACDIRYCTQDAFFQVKEVDVGLAADVGTLQRLPKVIGNRSLVNELTFTARKMMADEALDSGLVSRVFPDKDVMLNAAFALAADISSKSPVAVQGSKINLIYSRDHSVDESLDYMATWNMSMLQTQDIIKSVQAAMEKKDSKSITFSKL
transit_peptide: 1..33 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q62651.2) calculated_mol_wt: 3715 peptide sequence: MATAMTVSSKLLGLLMQQLRGTRQLYFNVSLRS mat_peptide: 34..327 product: Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q62651.2) calculated_mol_wt: 32504 peptide sequence: LSSSAQEASKRIPEEVSDHNYESIQVTSAQKHVLHVQLNRPEKRNAMNRAFWRELVECFQKISKDSDCRAVVVSGAGKMFTSGIDLMDMASDILQPPGDDVARIAWYLRDLISRYQKTFTVIEKCPKPVITAIHGGCIGGGVDLISACDIRYCTQDAFFQVKEVDVGLAADVGTLQRLPKVIGNRSLVNELTFTARKMMADEALDSGLVSRVFPDKDVMLNAAFALAADISSKSPVAVQGSKINLIYSRDHSVDESLDYMATWNMSMLQTQDIIKSVQAAMEKKDSKSITFSKL

Gene Information

Entrez Gene ID
64526
Gene Name
enoyl CoA hydratase 1, peroxisomal
Gene Symbol
Ech1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0016853 IEA:UniProtKB-KW F isomerase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
rno04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR014748 Crontonase, C-terminal
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
enoyl CoA hydratase 1, peroxisomal
Protein Entry
ECH1_RAT
UniProt ID
Q62651
Species
Rat

Comments

Comment Type Description
Function Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family
Subcellular Location Mitochondrion. Peroxisome.
Subunit Homohexamer

Identical and Related Proteins

Unique RefSeq proteins for LMP012709 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12018256 RefSeq NP_072116 327 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

Identical Sequences to LMP012709 proteins

Reference Database Accession Length Protein Name
GI:12018256 GenBank AAA82008.1 327 peroxisomal enoyl hydratase-like protein [Rattus norvegicus]

Related Sequences to LMP012709 proteins

Reference Database Accession Length Protein Name
GI:12018256 GenBank AAA82008.1 327 peroxisomal enoyl hydratase-like protein [Rattus norvegicus]
GI:12018256 GenBank EDM07870.1 327 enoyl coenzyme A hydratase 1, peroxisomal [Rattus norvegicus]
GI:12018256 SwissProt Q62651.2 327 RecName: Full=Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Flags: Precursor [Rattus norvegicus]