Gene/Proteome Database (LMPD)

LMPD ID
LMP012720
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
Synonyms
Hsj2;
Alternate Names
dnaJ homolog subfamily A member 1; HSJ-2; DnaJ-like protein 2; dnaJ-like protein 1; heat shock protein J2;
Chromosome
5
Map Location
5q22
Summary
interacts with the N-terminal fragment of hsc70; involved in DNA damage repair [RGD, Feb 2006]
Orthologs

Proteins

dnaJ homolog subfamily A member 1
Refseq ID NP_075223
Protein GI 12621094
UniProt ID P63036
mRNA ID NM_022934
Length 397
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
mat_peptide: 1..394 product: DnaJ homolog subfamily A member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P63036.1) calculated_mol_wt: 44552 peptide sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC

Gene Information

Entrez Gene ID
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:InterPro F ATP binding
GO:0030544 ISS:UniProtKB F Hsp70 protein binding
GO:0051087 ISS:UniProtKB F chaperone binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0042769 IDA:RGD P DNA damage response, detection of DNA damage
GO:0030521 IEA:Ensembl P androgen receptor signaling pathway
GO:0043508 ISS:UniProtKB P negative regulation of JUN kinase activity
GO:0043066 ISS:UniProtKB P negative regulation of apoptotic process
GO:0043065 ISS:UniProtKB P positive regulation of apoptotic process
GO:0006457 IEA:InterPro P protein folding
GO:0070585 ISS:UniProtKB P protein localization to mitochondrion
GO:0051223 ISS:UniProtKB P regulation of protein transport
GO:0009408 IEA:InterPro P response to heat
GO:0030317 IEA:Ensembl P sperm motility
GO:0007283 IEA:Ensembl P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko04141 Protein processing in endoplasmic reticulum
rno04141 Protein processing in endoplasmic reticulum

Domain Information

InterPro Annotations

Accession Description
IPR012724 Chaperone DnaJ
IPR002939 Chaperone DnaJ, C-terminal
IPR018253 DnaJ domain, conserved site
IPR001623 DnaJ_domain
IPR008971 HSP40/DnaJ peptide-binding
IPR001305 Heat shock protein DnaJ, cysteine-rich domain

UniProt Annotations

Entry Information

Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Protein Entry
DNJA1_RAT
UniProt ID
Species
Rat

Comments

Comment Type Description
Function Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity). Co- chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573). {ECO:0000250, ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:9605323}.
Similarity Contains 1 CR-type zinc finger
Similarity Contains 1 J domain
Subcellular Location Membrane ; Lipid-anchor {ECO:0000250}. Cytoplasm . Microsome . Mitochondrion . Nucleus . Cytoplasm, perinuclear region . Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria.
Subunit Identified in a complex with HSPA1B and BAX
Tissue Specificity Detected in liver (at protein level)

Identical and Related Proteins

Unique RefSeq proteins for LMP012720 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12621094 RefSeq NP_075223 397 dnaJ homolog subfamily A member 1

Identical Sequences to LMP012720 proteins

Reference Database Accession Length Protein Name
GI:12621094 GenBank AAI58025.1 397 DnaJ (Hsp40) homolog, subfamily A, member 1 [Mus musculus]
GI:12621094 RefSeq NP_001158143.1 397 dnaJ homolog subfamily A member 1 [Mus musculus]
GI:12621094 RefSeq NP_001158144.1 397 dnaJ homolog subfamily A member 1 [Mus musculus]
GI:12621094 RefSeq XP_006238161.1 397 PREDICTED: dnaJ homolog subfamily A member 1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012720 proteins

Reference Database Accession Length Protein Name
GI:12621094 DBBJ BAE39339.1 397 unnamed protein product [Mus musculus]
GI:12621094 DBBJ BAE26788.1 397 unnamed protein product [Mus musculus]
GI:12621094 RefSeq XP_006238161.1 397 PREDICTED: dnaJ homolog subfamily A member 1 isoform X1 [Rattus norvegicus]