Gene/Proteome Database (LMPD)
LMPD ID
LMP012720
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
Synonyms
Hsj2;
Alternate Names
dnaJ homolog subfamily A member 1; HSJ-2; DnaJ-like protein 2; dnaJ-like protein 1; heat shock protein J2;
Chromosome
5
Map Location
5q22
Summary
interacts with the N-terminal fragment of hsc70; involved in DNA damage repair [RGD, Feb 2006]
Orthologs
Proteins
dnaJ homolog subfamily A member 1 | |
---|---|
Refseq ID | NP_075223 |
Protein GI | 12621094 |
UniProt ID | P63036 |
mRNA ID | NM_022934 |
Length | 397 |
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS | |
mat_peptide: 1..394 product: DnaJ homolog subfamily A member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P63036.1) calculated_mol_wt: 44552 peptide sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC |
Gene Information
Entrez Gene ID
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005829 | IEA:Ensembl | C | cytosol |
GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0016020 | IEA:UniProtKB-KW | C | membrane |
GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
GO:0005524 | IEA:InterPro | F | ATP binding |
GO:0030544 | ISS:UniProtKB | F | Hsp70 protein binding |
GO:0051087 | ISS:UniProtKB | F | chaperone binding |
GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
GO:0042769 | IDA:RGD | P | DNA damage response, detection of DNA damage |
GO:0030521 | IEA:Ensembl | P | androgen receptor signaling pathway |
GO:0043508 | ISS:UniProtKB | P | negative regulation of JUN kinase activity |
GO:0043066 | ISS:UniProtKB | P | negative regulation of apoptotic process |
GO:0043065 | ISS:UniProtKB | P | positive regulation of apoptotic process |
GO:0006457 | IEA:InterPro | P | protein folding |
GO:0070585 | ISS:UniProtKB | P | protein localization to mitochondrion |
GO:0051223 | ISS:UniProtKB | P | regulation of protein transport |
GO:0009408 | IEA:InterPro | P | response to heat |
GO:0030317 | IEA:Ensembl | P | sperm motility |
GO:0007283 | IEA:Ensembl | P | spermatogenesis |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Protein Entry
DNJA1_RAT
UniProt ID
Species
Rat
Comments
Comment Type | Description |
---|---|
Function | Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity). Co- chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573). {ECO:0000250, ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:9605323}. |
Similarity | Contains 1 CR-type zinc finger |
Similarity | Contains 1 J domain |
Subcellular Location | Membrane ; Lipid-anchor {ECO:0000250}. Cytoplasm . Microsome . Mitochondrion . Nucleus . Cytoplasm, perinuclear region . Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria. |
Subunit | Identified in a complex with HSPA1B and BAX |
Tissue Specificity | Detected in liver (at protein level) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012720 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
12621094 | RefSeq | NP_075223 | 397 | dnaJ homolog subfamily A member 1 |
Identical Sequences to LMP012720 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:12621094 | GenBank | AAI58025.1 | 397 | DnaJ (Hsp40) homolog, subfamily A, member 1 [Mus musculus] |
GI:12621094 | RefSeq | NP_001158143.1 | 397 | dnaJ homolog subfamily A member 1 [Mus musculus] |
GI:12621094 | RefSeq | NP_001158144.1 | 397 | dnaJ homolog subfamily A member 1 [Mus musculus] |
GI:12621094 | RefSeq | XP_006238161.1 | 397 | PREDICTED: dnaJ homolog subfamily A member 1 isoform X1 [Rattus norvegicus] |
Related Sequences to LMP012720 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:12621094 | DBBJ | BAE39339.1 | 397 | unnamed protein product [Mus musculus] |
GI:12621094 | DBBJ | BAE26788.1 | 397 | unnamed protein product [Mus musculus] |
GI:12621094 | RefSeq | XP_006238161.1 | 397 | PREDICTED: dnaJ homolog subfamily A member 1 isoform X1 [Rattus norvegicus] |